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Research progress on copy number alterations in pediatric B-cell acute lymphoblastic leukemia
Xi-Yuan XU, Qun HU
Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (6) : 746-752.
PDF(586 KB)
PDF(586 KB)
Research progress on copy number alterations in pediatric B-cell acute lymphoblastic leukemia
Copy number alteration (CNA) is a significant genetic change in pediatric B-cell acute lymphoblastic leukemia (B-ALL), with CDKN2A/B deletions, PAX5 deletions, and IKZF1 deletions being the most common. Recent studies have increasingly highlighted the potential prognostic significance of these gene deletions and multiple co-deletions in pediatric B-ALL. This paper reviews the main detection methods for CNA, as well as the prognostic characteristics and treatment approaches for common CNA in pediatric B-ALL.
Acute lymphoblastic leukemia / Copy number alteration / Prognosis / Treatment / Child
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许喜原综述;胡群审校。