Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms

Qiong JIA; Yan-Hong YU; Yu-Jie WU; Tong-Yan HAN

doi:10.7499/j.issn.1008-8830.2509116

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Chinese Journal of Contemporary Pediatrics ›› 2026, Vol. 28 ›› Issue (5) : 624-628. DOI: 10.7499/j.issn.1008-8830.2509116

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Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms

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Abstract

The number of women with gestational obesity has been increasing year by year and is a serious global challenge. Maternal obesity during pregnancy not only leads to gestational diabetes, hypertension, preterm birth, and miscarriage, but also adversely affects offspring growth and development after birth by increasing the risk of offspring obesity and other metabolic diseases. Changes in the maternal gut microbiota during pregnancy and delivery play important roles, and microbiota-derived metabolites are closely related to the metabolic regulation of obesity. This review summarizes the potential mechanisms by which the maternal gut microbiota in gestational obesity influences offspring, aiming to deepen understanding of how maternal gut microbiota affects offspring and to provide research targets and ideas for clinical intervention.

Key words

Gestational obesity / Gut microbiota / Offspring obesity / Inflammation / Hormone

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Qiong JIA , Yan-Hong YU , Yu-Jie WU , et al. Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(5): 624-628 https://doi.org/10.7499/j.issn.1008-8830.2509116

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis

[1]

Zhu

, Zheng

, Pan

, et al. Association between prepregnancy body mass index or gestational weight gain and adverse pregnancy outcomes among Chinese women with gestational diabetes mellitus: a systematic review and meta-analysis[J]. BMJ Open, 2024, 14(2): e075226. PMCID: PMC10875528. DOI: 10.1136/bmjopen-2023-075226 .

https://www.ncbi.nlm.nih.gov/pubmed/38367974

Cited in this article [1]

[2]	Lackovic M, Jankovic M, Mihajlovic S, et al. Gestational weight gain, pregnancy related complications and the short-term risks for the offspring[J]. J Clin Med, 2024, 13(2): 445. PMCID: PMC10816050. DOI: 10.3390/jcm13020445 . https://www.ncbi.nlm.nih.gov/pubmed/38256578 Cited in this article [1]

[3]

Mora-Ortiz

, Rivas-García

. Gestational diabetes mellitus: unveiling maternal health dynamics from pregnancy through postpartum perspectives[J]. Open Res Eur, 2024, 4: 164. PMCID: PMC11443192. DOI: 10.12688/openreseurope.18026.2 .

https://www.ncbi.nlm.nih.gov/pubmed/39355538

Cited in this article [1]

[4]	Smid MC, Ricks NM, Panzer A, et al. Maternal gut microbiome biodiversity in pregnancy[J]. Am J Perinatol, 2018, 35(1): 24-30. PMCID: PMC6102712. DOI: 10.1055/s-0037-1604412 . https://www.ncbi.nlm.nih.gov/pubmed/28750469 Cited in this article [1]

[5]

Rautava

, Selma-Royo

, Oksanen

, et al. Shifting pattern of gut microbiota in pregnant women two decades apart: an observational study[J]. Gut Microbes, 2023, 15(1): 2234656. PMCID: PMC10361139. DOI: 10.1080/19490976.2023.2234656 .

https://www.ncbi.nlm.nih.gov/pubmed/37469006

Cited in this article [1]

[6]	Mei S, Chen Y, Long Y, et al. Association of gut microbiota with overweight/obesity combined with gestational diabetes mellitus[J]. J Med Microbiol, 2025, 74(5): 002010. PMCID: PMC12282309. DOI: 10.1099/jmm.0.002010 . https://www.ncbi.nlm.nih.gov/pubmed/40366751 Cited in this article [2]

[7]	Gilley SP, Ruebel ML, Sims C, et al. Associations between maternal obesity and offspring gut microbiome in the first year of life[J]. Pediatr Obes, 2022, 17(9): e12921. PMCID: PMC9641193. DOI: 10.1111/ijpo.12921 . https://www.ncbi.nlm.nih.gov/pubmed/35478493 Cited in this article [1]

[8]	Vallès Y, Arshad M, Abdalbaqi M, et al. The infants' gut microbiome: setting the stage for the early onset of obesity[J]. Front Microbiol, 2024, 15: 1371292. PMCID: PMC11287775. DOI: 10.3389/fmicb.2024.1371292 . https://www.ncbi.nlm.nih.gov/pubmed/39081889 Cited in this article [1]

[9]

Patra

, Chelikani

. Microencapsulated propionate and butyrate improved energy balance and gut microbiota composition in diet-induced obese rats[J]. Nutrients, 2025, 17(13): 2180. PMCID: PMC12251328. DOI: 10.3390/nu17132180 .

https://www.ncbi.nlm.nih.gov/pubmed/40647300

Cited in this article [1]

[10]	Ziętek M, Celewicz Z, Szczuko M. Short-chain fatty acids, maternal microbiota and metabolism in pregnancy[J]. Nutrients, 2021, 13(4): 1244. PMCID: PMC8069164. DOI: 10.3390/nu13041244 . https://www.ncbi.nlm.nih.gov/pubmed/33918804 Cited in this article [1]

[11]	Mann PE, Huynh K, Widmer G. Maternal high fat diet and its consequence on the gut microbiome: a rat model[J]. Gut Microbes, 2018, 9(2): 143-154. PMCID: PMC5989793. DOI: 10.1080/19490976.2017.1395122 . https://www.ncbi.nlm.nih.gov/pubmed/29135334 Cited in this article [1]

[12]	Coscia A, Bardanzellu F, Caboni E, et al. When a neonate is born, so is a microbiota[J]. Life (Basel), 2021, 11(2): 148. PMCID: PMC7920069. DOI: 10.3390/life11020148 . https://www.ncbi.nlm.nih.gov/pubmed/33669262 Cited in this article [1]

[13]	Kaisanlahti A, Turunen J, Byts N, et al. Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles[J]. Microbiome, 2023, 11(1): 249. PMCID: PMC10642029. DOI: 10.1186/s40168-023-01694-9 . https://www.ncbi.nlm.nih.gov/pubmed/37953319 Cited in this article [1]

[14]

Zhang

, Liu

, Zheng

, et al. Effects of the maternal gut microbiome and gut-placental axis on melatonin efficacy in alleviating cadmium-induced fetal growth restriction[J]. Ecotoxicol Environ Saf, 2022, 237: 113550. DOI: 10.1016/j.ecoenv.2022.113550 .

https://www.ncbi.nlm.nih.gov/pubmed/35487173

Cited in this article [1]

[15]

Faienza

, Urbano

, Anaclerio

, et al. Exploring maternal diet-epigenetic-gut microbiome crosstalk as an intervention strategy to counter early obesity programming[J]. Curr Issues Mol Biol, 2024, 46(5): 4358-4378. PMCID: PMC11119222. DOI: 10.3390/cimb46050265 .

https://www.ncbi.nlm.nih.gov/pubmed/38785533

Cited in this article [1]

[16]

, Zhang

, Zhou

, et al. Polysaccharides from lactarius volemus Fr. ameliorate high-fat and high-fructose diet induced metabolic disorders and intestinal barrier dysfunction[J]. Int J Biol Macromol, 2025, 287: 138341. DOI: 10.1016/j.ijbiomac.2024.138341 .

https://www.ncbi.nlm.nih.gov/pubmed/39638176

Cited in this article [1]

[17]	Basak S, Das RK, Banerjee A, et al. Maternal obesity and gut microbiota are associated with fetal brain development[J]. Nutrients, 2022, 14(21): 4515. PMCID: PMC9654759. DOI: 10.3390/nu14214515 . https://www.ncbi.nlm.nih.gov/pubmed/36364776 Cited in this article [1]

[18]

Wekema

, Schoenmakers

, Schenkelaars

, et al. Obesity and diet independently affect maternal immunity, maternal gut microbiota and pregnancy outcome in mice[J]. Front Immunol, 2024, 15: 1376583. PMCID: PMC11272480. DOI: 10.3389/fimmu.2024.1376583 .

https://www.ncbi.nlm.nih.gov/pubmed/39072322

Cited in this article [1]

[19]

Baştemur

, Gezer

İS

, Kesikli

, et al. The influence of dietary choices: investigation of the relationship dietary inflammatory index and fetal growth restriction[J]. BMC Pregnancy Childbirth, 2025, 25(1): 569. PMCID: PMC12076950. DOI: 10.1186/s12884-025-07674-1 .

https://www.ncbi.nlm.nih.gov/pubmed/40369425

Cited in this article [1]

[20]	Dutta-Roy AK. Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta[J]. Am J Clin Nutr, 2000, 71(1 ): 315S-322S. DOI: 10.1093/ajcn/71.1.315s . https://www.ncbi.nlm.nih.gov/pubmed/10617989 Cited in this article [1] Abstract Suppl

[21]

Unlu

, Vinales

, Hollstein

, et al. The association between gut hormones and diet-induced metabolic flexibility in metabolically healthy adults[J]. Obesity (Silver Spring), 2023, 31(1): 139-149. PMCID: PMC9780166. DOI: 10.1002/oby.23584 .

https://www.ncbi.nlm.nih.gov/pubmed/36471908

Cited in this article [1]

[22]

Jardon

, Umanets

, Gijbels

, et al. Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity[J]. Gut Microbes, 2025, 17(1): 2501185. PMCID: PMC12064058. DOI: 10.1080/19490976.2025.2501185 .

https://www.ncbi.nlm.nih.gov/pubmed/40336254

Cited in this article [1]

[23]	Ørgaard A, Jepsen SL, Holst JJ. Short-chain fatty acids and regulation of pancreatic endocrine secretion in mice[J]. Islets, 2019, 11(5): 103-111. PMCID: PMC6773373. DOI: 10.1080/19382014.2019.1587976 . https://www.ncbi.nlm.nih.gov/pubmed/31469342 Cited in this article [1]

[24]	Elwan D, Olveda R, Medrano R, et al. Excess pregnancy weight gain in latinas: impact on infant's adiposity and growth hormones at birth[J]. Prev Med Rep, 2021, 22: 101341. PMCID: PMC8053797. DOI: 10.1016/j.pmedr.2021.101341 . https://www.ncbi.nlm.nih.gov/pubmed/33898205 Cited in this article [1]

[25]	Kimura I, Miyamoto J, Ohue-Kitano R, et al. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice[J]. Science, 2020, 367(6481): eaaw8429. DOI: 10.1126/science.aaw8429 . https://www.ncbi.nlm.nih.gov/pubmed/32108090 Cited in this article [1]

[26]

Mei

, Li

, Zhang

, et al. Maternal phlorizin intake protects offspring from maternal obesity-induced metabolic disorders in mice via targeting gut microbiota to activate the SCFA-GPR43 pathway[J]. J Agric Food Chem, 2024, 72(9): 4703-4725. DOI: 10.1021/acs.jafc.3c06370 .

https://www.ncbi.nlm.nih.gov/pubmed/38349207

Cited in this article [1]

[27]

Soderborg

, Carpenter

, Janssen

, et al. Gestational diabetes is uniquely associated with altered early seeding of the infant gut microbiota[J]. Front Endocrinol (Lausanne), 2020, 11: 603021. PMCID: PMC7729132. DOI: 10.3389/fendo.2020.603021 .

https://www.ncbi.nlm.nih.gov/pubmed/33329403

Cited in this article [1]

[28]

Safarzadeh

, Aliramezani

, Rahimi

, et al. The advantages of Faecalibacterium prasnitzii in gestational diabetes mellitus[J]. Future Microbiol, 2025, 20(10): 695-706. PMCID: PMC12239820. DOI: 10.1080/17460913.2025.2520699 .

https://www.ncbi.nlm.nih.gov/pubmed/40579233

Cited in this article [1]

[29]	Yi Y, Wang T, Xu W, et al. Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring[J]. World J Diabetes, 2024, 15(3): 378-391. PMCID: PMC10999040. DOI: 10.4239/wjd.v15.i3.378 . https://www.ncbi.nlm.nih.gov/pubmed/38591094 Cited in this article [1]

[30]

Suleiman

, Akorede

, Afisu

, et al. The epigenetic influence of diet-induced gut microbiome changes in precision nutrition: a systematic review[J]. Gastroenterol Hepatol Bed Bench, 2025, 18(3): 270-285. PMCID: PMC12535778. DOI: 10.22037/ghfbb.v18i3.3136 .

https://www.ncbi.nlm.nih.gov/pubmed/41116849

Cited in this article [1]

[31]

Rubini

, Schenkelaars

, Rousian

, et al. Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing[J]. Am J Obstet Gynecol, 2022, 227(3): 392-400. DOI: 10.1016/j.ajog.2022.04.013 .

https://www.ncbi.nlm.nih.gov/pubmed/35452650

Cited in this article [1]

[32]

Evidence Reviews for Optimum Folic Acid Supplementation Dose Before and During the First 12 Weeks of Pregnancy for Those with a BMI 25 kg/m² or More: Maternal and Child Nutrition: Evidence Review B[M]. London: National Institute for Health and Care Excellence (NICE), 2025.

Cited in this article [1]

[33]

Zhang

, Zhang

, Zhao

, et al. Folic acid prevents high-fat diet-induced postpartum weight retention in rats, which is associated with a reduction in endoplasmic reticulum stress-mediated hepatic lipogenesis[J]. Nutrients, 2024, 16(24): 4377. PMCID: PMC11676124. DOI: 10.3390/nu16244377 .

https://www.ncbi.nlm.nih.gov/pubmed/39770997

Cited in this article [1]

[34]	Zhu J, Saikia G, Zhang X, et al. One-carbon metabolism nutrients, genetic variation, and diabetes mellitus[J]. Diabetes Metab J, 2024, 48(2): 170-183. PMCID: PMC10995489. DOI: 10.4093/dmj.2023.0272 . https://www.ncbi.nlm.nih.gov/pubmed/38468500 Cited in this article [1]

[35]

Kadam

, Nebie

, Dalloul

, et al. Associations of choline intake and metabolite status with fetal growth outcomes and placental macronutrient transport in pregnancies with or without gestational diabetes mellitus[J]. Clin Nutr, 2025, 52: 179-188. DOI: 10.1016/j.clnu.2025.07.027 .

https://www.ncbi.nlm.nih.gov/pubmed/40780129

Cited in this article [1]

[36]

Romano

, Martinez-Del Campo

, Kasahara

, et al. Metabolic, epigenetic, and transgenerational effects of gut bacterial choline consumption[J]. Cell Host Microbe, 2017, 22(3): 279-290.e7. PMCID: PMC5599363. DOI: 10.1016/j.chom.2017.07.021 .

https://www.ncbi.nlm.nih.gov/pubmed/28844887

Cited in this article [1]

[37]

Ren

, Zhou

, Li

, et al. The roles of the gut microbiota, metabolites, and epigenetics in the effects of maternal exercise on offspring metabolism[J]. Am J Physiol Endocrinol Metab, 2024, 327(6): E760-E772. DOI: 10.1152/ajpendo.00200.2024 .

https://www.ncbi.nlm.nih.gov/pubmed/39535269

Cited in this article [1]

[38]	Sheyholislami H, Connor KL. Are probiotics and prebiotics safe for use during pregnancy and lactation? A systematic review and meta-analysis[J]. Nutrients, 2021, 13(7): 2382. PMCID: PMC8308823. DOI: 10.3390/nu13072382 . https://www.ncbi.nlm.nih.gov/pubmed/34371892 Cited in this article [1]

[39]

Alemu

, Wu

, Azeze

, et al. Microbiota-targeted interventions and clinical implications for maternal-offspring health: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials[J]. J Glob Health, 2024, 14: 04177. PMCID: PMC11395958. DOI: 10.7189/jogh.14.04177 .

https://www.ncbi.nlm.nih.gov/pubmed/39269153

Cited in this article [1]

[40]

Wiedmer

, Herter-Aeberli

. The potential of prebiotic and probiotic supplementation during obese pregnancy to improve maternal and offspring's metabolic health and reduce obesity risk: a narrative review[J]. Front Nutr, 2022, 9: 819882. PMCID: PMC9021550. DOI: 10.3389/fnut.2022.819882 .

https://www.ncbi.nlm.nih.gov/pubmed/35464026

Cited in this article [1]