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Epidemiology, clinical characteristics, and treatment patterns of pediatric systemic lupus erythematosus based on regional electronic healthcare data in Beijing
Jia-Rui XU, Yu-Tong WANG, Sheng-Feng WANG, Xu-Hui ZHONG, Yu-Wu JIANG, Jie DING
Chinese Journal of Contemporary Pediatrics ›› 2026, Vol. 28 ›› Issue (9) : 1078-1085.
PDF(890 KB)
PDF(890 KB)
Epidemiology, clinical characteristics, and treatment patterns of pediatric systemic lupus erythematosus based on regional electronic healthcare data in Beijing
Objective To explore recent temporal trends in pediatric systemic lupus erythematosus (SLE) in Beijing. Methods Electronic health record data were extracted from the Beijing Hospital Quality Monitoring System and the Beijing Electronic Medical Record Sharing Project (30 pilot hospitals). Changes in epidemiology, clinical characteristics, and treatment patterns were analyzed for the period June 2015 to May 2023. Results A total of 4 197 pediatric SLE patients were included, of whom 874 (20.82%) were male. Among 3 361 children with disease onset after May 31, 2016, the median age at onset was 12 years. From 2016 to 2022, the incidence of SLE among children aged 0-14 years in Beijing increased from 2.91 to 6.02 per 100 000. From 2015 to 2022, the incidence of renal (RR=1.02) and hematologic (RR=1.16) damage in hospitalized children showed a significant upward trend (P<0.05). Over the same period, cyclophosphamide use declined from 59.8% to 29.0% (P<0.05), while the use of hydroxychloroquine (RR=1.09), mycophenolate mofetil (RR=1.11), and tacrolimus (RR=1.29) increased significantly (P<0.05). Conclusions In Beijing, data from 2015-2022 indicate a rising incidence of pediatric SLE, an increasing burden of organ damage among hospitalized patients, and marked shifts in treatment patterns.
Systemic lupus erythematosus / Real-world data / Epidemiology / Treatment pattern / Child
| [1] |
|
| [2] |
|
| [3] |
|
| [4] |
|
| [5] |
|
| [6] |
国家皮肤与免疫疾病临床医学研究中心, 中国系统性红斑狼疮研究协作组, 中华医学会风湿病学分会. 中国系统性红斑狼疮诊疗指南(2025版)[J]. 中华医学杂志, 2025, 105(23): 1879-1906. DOI: 10.3760/cma.j.cn112137-20250228-00479 .
|
| [7] |
北京市统计局, 国家统计局北京调查总队. 北京统计年鉴(2023)[M]. 北京: 中国统计出版社, 2023.
|
| [8] |
|
| [9] |
|
| [10] |
Anon. Guidelines for referral and management of systemic lupus erythematosus in adults. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines[J]. Arthritis Rheum, 1999, 42(9): 1785-1796. DOI: 10.1002/1529-0131(199909)42:9<1785::AID-ANR1>3.0.CO;2- #.
|
| [11] |
Anon. Chapter 12: lupus nephritis[J]. Kidney Int Suppl (2011), 2012, 2(2): 221-232. PMCID: PMC4089588. DOI: 10.1038/kisup.2012.25 .
|
| [12] |
中华医学会儿科学分会肾脏学组. 狼疮性肾炎诊治循证指南(2016)[J]. 中华儿科杂志, 2018, 56(2): 88-94. DOI: 10.3760/cma.j.issn.0578-1310.2018.02.003 .
|
| [13] |
|
| [14] |
|
| [15] |
|
| [16] |
|
| [17] |
|
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