Pediatric thunderstorm asthma in China: epidemiological characteristics and comprehensive management

Peng HAN, Kun-Ling SHEN

Chinese Journal of Contemporary Pediatrics ›› 2026, Vol. 28 ›› Issue (9) : 1043-1051.

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Chinese Journal of Contemporary Pediatrics ›› 2026, Vol. 28 ›› Issue (9) : 1043-1051. DOI: 10.7499/j.issn.1008-8830.2605034
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Pediatric thunderstorm asthma in China: epidemiological characteristics and comprehensive management

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Abstract

Thunderstorm asthma is defined as acute asthma exacerbations occurring during or shortly after thunderstorms, characterized by sudden onset, wide geographic impact, and clustering of cases. Climate change is driving more frequent extreme weather and higher aeroallergen concentrations, making future thunderstorm asthma episodes more frequent and less predictable. In China, the geographic range of pediatric thunderstorm asthma is expanding and its disease burden is underestimated. This paper reviews the literature on thunderstorm asthma in Chinese children, integrates global advances in mechanisms and management, and provides a comprehensive analysis of the epidemiology, pathogenesis, and clinical management of pediatric thunderstorm asthma in China. Regional variation is evident, with historical predominance in northern regions and recent reports from southern cities. Children with seasonal allergic rhinitis constitute a hidden high-risk population; even without an asthma diagnosis, enhanced surveillance and preventive management are warranted. Core components of comprehensive management include graded acute-phase care, pollen concentration monitoring with early warning, and pre-thunderstorm prophylactic medication.

Key words

Thunderstorm asthma / Climate change / Epidemiology / High-risk population / Pollen allergy / Comprehensive management / Child

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Peng HAN , Kun-Ling SHEN. Pediatric thunderstorm asthma in China: epidemiological characteristics and comprehensive management[J]. Chinese Journal of Contemporary Pediatrics. 2026, 28(9): 1043-1051 https://doi.org/10.7499/j.issn.1008-8830.2605034

References

[1]
Venkatesan P. Epidemic thunderstorm asthma[J]. Lancet Respir Med, 2022, 10(4): 325-326. DOI: 10.1016/S2213-2600(22)00083-2 .
[2]
Packe GE, Ayres JG. Asthma outbreak during a thunderstorm[J]. Lancet, 1985, 2(8448): 199-204. DOI: 10.1016/s0140-6736(85)91510-7 .
[3]
Han P, Shen KL. Climate change and thunderstorm asthma in children: challenges and responses[J]. World J Pediatr, 2026, 22(2): 159-166. DOI: 10.1007/s12519-025-01012-3 .
[4]
Price D, Hughes KM, Thien F, et al. Epidemic thunderstorm asthma: lessons learned from the storm down-under[J]. J Allergy Clin Immunol Pract, 2021, 9(4): 1510-1515. DOI: 10.1016/j.jaip.2020.10.022 .
[5]
Mastorci F, Linzalone N, Ait-Ali L, et al. Environment in children's health: a new challenge for risk assessment[J]. Int J Environ Res Public Health, 2021, 18(19): 10445. PMCID: PMC8507725. DOI: 10.3390/ijerph181910445 .
[6]
Perera F, Nadeau K. Climate change, fossil-fuel pollution, and children's health[J]. N Engl J Med, 2022, 386(24): 2303-2314. DOI: 10.1056/NEJMra2117706 .
[7]
Han P, Shen KL. Extreme weather and pediatric respiratory health: insights from GINA 2025[J]. World J Pediatr, 2026, 22(4): 398-403. DOI: 10.1007/s12519-026-01033-6 .
[8]
Jutel M, Mosnaim GS, Bernstein JA, et al. The one health approach for allergic diseases and asthma[J]. Allergy, 2023, 78(7): 1777-1793. DOI: 10.1111/all.15755 .
[9]
Atwoli L, Baqui AH, Benfield T, et al. Call for emergency action to limit global temperature increases, restore biodiversity, and protect health[J]. N Engl J Med, 2021, 385(12): 1134-1137. DOI: 10.1056/NEJMe2113200 .
[10]
Xu YY, Xue T, Li HR, et al. Retrospective analysis of epidemic thunderstorm asthma in children in Yulin, northwest China[J]. Pediatr Res, 2021, 89(4): 958-961. DOI: 10.1038/s41390-020-0980-9 .
[11]
孙伟, 龚瑞, 高洁, 等. 宁夏过敏性哮喘暴发事件调查分析[J]. 职业卫生与应急救援, 2021, 39(6): 693-695. DOI: 10.16369/j.oher.issn.1007-1326.2021.06.019 .
[12]
严梅, 靳泉鹏, 褚娇娇, 等. 一起群体性雷暴哮喘的调查分析[J]. 宁夏医学杂志, 2023, 45(3): 270-273. DOI: 10.13621/j.1001-5949.2023.03.0270 .
[13]
Hao W, Ye W, Liu X, et al. Comparative study on two epidemic thunderstorm-asthma events: a retrospective analysis of cases in Yulin in 2022 and 2025[J]. Int Arch Allergy Immunol, 2026. Epub ahead of print. DOI: 10.1159/000551697 .
[14]
张瑶, 雷菁, 蒋杉杉, 等. 与雷暴相关的急性呼吸系统疾病: 宁夏连续两起雷暴哮喘特点分析[J]. 中华急诊医学杂志, 2024, 33(11): 1580-1585. DOI: 10.3760/cma.j.issn.1671-0282.2024.11.018 .
[15]
刘德艳, 柴少卿, 李俊利, 等. 内蒙古呼和浩特地区儿童雷暴哮喘事件回顾性分析[J]. 中华实用儿科临床杂志, 2024, 39(5): 364-368. DOI: 10.3760/cma.j.cn101070-20240329-00188 .
[16]
Fan C, Li X, Cai H, et al. Epidemic thunderstorm asthma in Hohhot, Northern China: a retrospective analysis of clinical characteristics in 155 patients[J]. J Allergy Clin Immunol Pract, 2024, 12(9): 2514-2516.e1. DOI: 10.1016/j.jaip.2024.06.012 .
[17]
Yi G, Yang L, Hu G, et al. Investigation of a thunderstorm asthma event: Chongqing municipality, China, April 2024[J]. China CDC Wkly, 2025, 7(27): 926-930. PMCID: PMC12259383. DOI: 10.46234/ccdcw2025.155 .
[18]
黄飞月, 刘丽萍, 张克标, 等. 重庆市125例流行性雷暴哮喘患者应急救治的回顾性分析[J]. 职业卫生与应急救援, 2025, 43(4): 536-538. DOI: 10.16369/j.oher.issn.1007-1326.2025.240642 .
[19]
周薇, 严宇, 黄静, 等. 重庆地区55例春季雷暴哮喘回顾性分析[J]. 中华预防医学杂志, 2025, 59(12): 2082-2089. DOI: 10.3760/cma.j.cn112150-20250509-00412 .
[20]
杨秀芬, 邹林, 王丙栋, 等. 2024年深圳地区夏季60例雷暴哮喘患者回顾性分析[J]. 中国急救复苏与灾害医学杂志, 2025, 20(10): 1331-1335. DOI: 10.3969/j.issn.1673-6966.2025.10.016 .
[21]
桑迎竹, 雷丰丰, 肖晓辉, 等. 兰州市125例雷暴哮喘住院患者临床特征分析[J]. 中华内科杂志, 2026, 65(4): 346-351. DOI: 10.3760/cma.j.cn112138-20251117-00696 .
[22]
常洁, 张晓娟, 李文, 等. 雷暴哮喘合并塑形支气管炎3例[J]. 中华儿科杂志, 2026, 64(4): 442-444. DOI: 10.3760/cma.j.cn112140-20251209-01089 .
[23]
顾建青, 何海娟, 王良录, 等. 2010年北京城区气传真菌监测[J]. 中华临床免疫和变态反应杂志, 2018, 12(4): 379-383. DOI: 10.3969/j.issn.1673-8705.2018.04.002 .
[24]
宋文静, 吴绍洪, 陶泽兴, 等. 近30年中国中东部地区植物分布变化[J]. 地理研究, 2016, 35(8): 1420-1432. DOI: 10.11821/dlyj201608002 .
[25]
Rana SK, Rana HK, Stöcklin J, et al. Global warming pushes the distribution range of the two alpine 'glasshouse' Rheum species north- and upwards in the Eastern Himalayas and the Hengduan Mountains[J]. Front Plant Sci, 2022, 13: 925296. PMCID: PMC9585287. DOI: 10.3389/fpls.2022.925296 .
[26]
Ziska L, Knowlton K, Rogers C, et al. Recent warming by latitude associated with increased length of ragweed pollen season in central North America[J]. Proc Natl Acad Sci U S A, 2011, 108(10): 4248-4251. PMCID: PMC3053965. DOI: 10.1073/pnas.1014107108 .
[27]
Cecchi L, D'Amato G, Annesi-Maesano I. External exposome and allergic respiratory and skin diseases[J]. J Allergy Clin Immunol, 2018, 141(3): 846-857. DOI: 10.1016/j.jaci.2018.01.016 .
[28]
Wayne P, Foster S, Connolly J, et al. Production of allergenic pollen by ragweed (Ambrosia artemisiifolia L.) is increased in CO2-enriched atmospheres[J]. Ann Allergy Asthma Immunol, 2002, 88(3): 279-282. DOI: 10.1016/S1081-1206(10)62009-1 .
[29]
Venkatesan S, Zare A, Stevanovic S. Pollen and sub-pollen particles: external interactions shaping the allergic potential of pollen[J]. Sci Total Environ, 2024, 926: 171593. DOI: 10.1016/j.scitotenv.2024.171593 .
[30]
Ziska LH, Gebhard DE, Frenz DA, et al. Cities as harbingers of climate change: common ragweed, urbanization, and public health[J]. J Allergy Clin Immunol, 2003, 111(2): 290-295. DOI: 10.1067/mai.2003.53 .
[31]
Behrendt H, Becker WM, Friedrichs KH, et al. Interaction between aeroallergens and airborne particulate matter[J]. Int Arch Allergy Immunol, 1992, 99(2/4): 425-428. DOI: 10.1159/000236303 .
[32]
Dhawan S, Kumar A, Mehta DS, et al. A review of airborne pollen and its interactions with air pollutants, urbanization, and climate change: implications for human health and monitoring Gaps[J]. Curr Allergy Asthma Rep, 2025, 25(1): 62. DOI: 10.1007/s11882-025-01241-6 .
[33]
Niu Z, Fang X, Sun J, et al. Exposure to anthropogenic heat was associated with the increased risks of respiratory allergy symptoms in preschool children: a new insight into the urban heat island effect[J]. Environ Sci Technol, 2025, 59(24): 12060-12073. DOI: 10.1021/acs.est.5c02190 .
[34]
Thien F, Davies JM, Hew M, et al. Thunderstorm asthma: an overview of mechanisms and management strategies[J]. Expert Rev Clin Immunol, 2020, 16(10): 1005-1017. DOI: 10.1080/1744666X.2021.1826310 .
[35]
Suphioglu C. Thunderstorm asthma due to grass pollen[J]. Int Arch Allergy Immunol, 1998, 116(4): 253-260.
[36]
Venkatesan S, Zare A, Alinaghipour B, et al. Impact of atmospheric charge regimes (static fields and arcing) on airborne tree pollen rupture under dry and wet conditions[J]. Environ Sci Technol, 2026, 60(13): 10129-10138. DOI: 10.1021/acs.est.5c16155 .
[37]
Hughes KM, Price D, Suphioglu C. Importance of allergen-environment interactions in epidemic thunderstorm asthma[J]. Ther Adv Respir Dis, 2022, 16: 17534666221099733. PMCID: PMC9134402. DOI: 10.1177/17534666221099733 .
[38]
Deng T, Zhang J, Liu H, et al. Effects of thunderstorm weather and pollen on respiratory allergic diseases[J]. Int J Environ Health Res, 2026. Epub ahead of print. DOI: 10.1080/09603123.2026.2627346 .
[39]
Qin X, Li Y, Zhang H, et al. Interactions among Cupressaceae pollen, air pollutants and meteorology in the urban and suburban areas of Beijing, China[J]. Sci Rep, 2025, 15(1): 14184. PMCID: PMC12019579. DOI: 10.1038/s41598-025-98316-1 .
[40]
Lu Q, Zhang QH, Xin PL, et al. Impact of meteorological parameters and air pollutants on weed pollen-induced allergic rhinitis symptoms in Dalian, China[J]. Int Arch Allergy Immunol, 2026, 187(8): 809-821. DOI: 10.1159/000548918 .
[41]
Lu Y, Jie X, Zou F, et al. Investigation analysis of the acute asthma risk factor and phenotype based on relational analysis with outdoor air pollutants in Xi'an, China[J]. Environ Geochem Health, 2024, 46(3): 75. DOI: 10.1007/s10653-023-01816-0 .
[42]
D'Amato G, Annesi-Maesano I, Urrutia-Pereira M, et al. Thunderstorm allergy and asthma: state of the art[J]. Multidiscip Respir Med, 2021, 16(1): 806. PMCID: PMC8672486. DOI: 10.4081/mrm.2021.806 .
[43]
中国医药教育协会儿科专业委员会, 中华医学会儿科学分会呼吸学组哮喘协作组, 中国医师协会呼吸医师分会儿科呼吸工作委员会, 等. 中国儿童雷暴哮喘专家共识[J]. 中华实用儿科临床杂志, 2024, 39(5): 321-326. DOI: 10.3760/cma.j.cn101070-20240417-00243 .
[44]
Hew M, Lee J, Susanto NH, et al. The 2016 Melbourne thunderstorm asthma epidemic: risk factors for severe attacks requiring hospital admission[J]. Allergy, 2019, 74(1): 122-130. DOI: 10.1111/all.13609 .
[45]
Thien F, Beggs PJ, Csutoros D, et al. The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors[J]. Lancet Planet Health, 2018, 2(6): e255-e263. DOI: 10.1016/S2542-5196(18)30120-7 .
[46]
北京整合医学学会变态反应学分会, 北京医学会过敏(变态)反应学分会, 中华医学会变态反应学分会, 等. 雷暴哮喘防控专家共识[J]. 中华预防医学杂志, 2026, 60(3): 301-314. DOI: 10.3760/cma.j.cn112150-20251229-01236 .
[47]
中华医学会儿科学分会呼吸学组, 中华儿科杂志编辑委员会, 中国医药教育协会儿科专业委员会. 儿童支气管哮喘诊断与防治指南(2025)[J]. 中华儿科杂志, 2025, 63(4): 324-337. DOI: 10.3760/cma.j.cn112140-20250124-00074 .
[48]
Almohammadi AA. Climate change and pediatric respiratory health: an emerging paradigm in prevention and critical care[J]. Pediatr Respirol Crit Care Med, 2026, 10(1): 3-10. DOI: 10.4103/prcm.prcm_22_25 .
[49]
国家呼吸系统疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组哮喘协作组, 中国医药教育协会儿科专业委员会, 等. 中国儿童哮喘行动计划临床应用专家共识[J]. 中华实用儿科临床杂志, 2021, 36(7): 484-490. DOI: 10.3760/cma.j.cn101070-20210310-00290 .
[50]
国家呼吸系统疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组哮喘协作组, 中国医药教育协会儿科专业委员会, 等. 中国儿童哮喘行动计划“百问百答”[J]. 中华实用儿科临床杂志, 2021, 36(7): 491-513. DOI: 10.3760/cma.j.cn101070-20210310-00289 .
[51]
O'Hehir RE, Varese NP, Deckert K, et al. Epidemic thunderstorm asthma protection with five-grass pollen tablet sublingual immunotherapy: a clinical trial[J]. Am J Respir Crit Care Med, 2018, 198(1): 126-128. DOI: 10.1164/rccm.201711-2337LE .
[52]
Tang L, Wang P, Yang X, et al. Artemisia annua sublingual immunotherapy in children with seasonal allergic rhinitis[J]. Allergy, 2024, 79(5): 1376-1379. DOI: 10.1111/all.16073 .
[53]
Li J, Liu W, Xu YJ, et al. Coseasonal initiation of Artemisia annua sublingual immunotherapy in children and adult patients with allergic rhinoconjunctivitis[J]. Eur Arch Otorhinolaryngol, 2025, 282(2): 843-850. DOI: 10.1007/s00405-024-09088-9 .
[54]
Feng Y, Zhao Y, Hu HX, et al. Artemisia annua sublingual immunotherapy in pediatric patients with seasonal allergic rhinoconjunctivitis: comparison to adult patients[J]. Asia Pac Allergy, 2025, 15(2): 82-88. PMCID: PMC12289075. DOI: 10.5415/apallergy.0000000000000197 .
[55]
Xu C, Zhao Y, Huang H, et al. Effects of artemisia annua-sublingual immunotherapy on asthma control and pulmonary function in patients with mild-moderate allergic asthma[J]. Int Arch Allergy Immunol, 2025, 186(10): 956-966. DOI: 10.1159/000543864 .
[56]
Lou H, Ma S, Zhao Y, et al. Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China[J]. Sci Rep, 2017, 7(1): 9286. PMCID: PMC5570894. DOI: 10.1038/s41598-017-10111-9 .
[57]
Komlósi ZI, Kovács N, Sokolowska M, et al. Mechanisms of subcutaneous and sublingual aeroallergen immunotherapy: what is new?[J]. Immunol Allergy Clin North Am, 2020, 40(1): 1-14. DOI: 10.1016/j.iac.2019.09.009 .
[58]
Hirano K, Suzaki I, Uruma S, et al. Impact of omalizumab on pollen-induced seasonal allergic rhinitis: an observational study in clinical practice[J]. Int Forum Allergy Rhinol, 2021, 11(11): 1588-1591. DOI: 10.1002/alr.22827 .
[59]
Serrano P, Navas A, Ruiz-León B, et al. Seasonal administration of omalizumab in patients with uncontrolled asthma and sensitization to olive pollen[J]. J Investig Allergol Clin Immunol, 2021, 31(5): 436-438. DOI: 10.18176/jiaci.0657 .
[60]
李丽莎, 关凯, 王子熹, 等. 奥马珠单抗治疗柏树花粉过敏所致季节性变应性鼻炎的效果[J]. 中华临床免疫和变态反应杂志, 2022, 16(6): 569-574. DOI: 10.3969/j.issn.1673-8705.2022.06.001 .
[61]
马婷婷, 王向东, 陈艳蕾, 等. 奥马珠单抗治疗花粉症伴中重度哮喘患者的临床疗效及安全性研究[J]. 中国耳鼻咽喉头颈外科, 2018, 25(12): 675-678. DOI: 10.16066/j.1672-7002.2018.12.012 .
[62]
李世纪, 高云博, 张媛, 等. 奥马珠单抗季节前治疗季节性变应性鼻炎的药物经济学评价[J]. 中华耳鼻咽喉头颈外科杂志, 2025, 60(4): 427-434. DOI: 10.3760/cma.j.cn115330-20240612-00346-1 .
[63]
国家呼吸系统疾病临床医学研究中心, 中华医学会儿科学分会呼吸学组哮喘协作组, 中国医药教育协会儿科专业委员会, 等. 奥马珠单抗在儿童过敏性哮喘临床应用专家共识[J]. 中华实用儿科临床杂志, 2021, 36(12): 881-890. DOI: 10.3760/cma.j.cn101070-20210531-00621 .
[64]
Anderson BJ, Harding AM, Taylor SE, et al. Thunderstorm asthma medication management during an external emergency (code brown): an observational study of the impact of electronic prescribing and clinical documentation[J]. Australas Emerg Care, 2020, 23(4): 259-264. DOI: 10.1016/j.auec.2020.05.002 .
[65]
王洪田, 张俊晶, 马婷婷, 等. 雷暴哮喘的突发公共卫生事件分级响应及应急处置对策[J]. 中华卫生应急电子杂志, 2025, 11(1): 1-5. DOI: 10.3877/cma.j.issn.2095-9133.2025.01.001 .
[66]
宁夏医学会呼吸病学分会, 宁夏医师协会呼吸医师分会, 宁夏医学会变态反应学分会, 等. 宁夏雷暴哮喘应急管理与对策[J]. 宁夏医科大学学报, 2025, 47(9): 865-875. DOI: 10.16050/j.cnki.issn1674-6309.2025.09.001 .
[67]
Erbas B, Akram M, Dharmage SC, et al. The role of seasonal grass pollen on childhood asthma emergency department presentations[J]. Clin Exp Allergy, 2012, 42(5):799-805. DOI:10.1111/j.1365-2222.2012.03995.x .
[68]
Middleton J, Rorie AC. The impact of extreme weather events on allergic airway disease[J]. Curr Allergy Asthma Rep, 2026, 26(1): 16. DOI: 10.1007/s11882-026-01261-w .

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