Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation

XIA Li-Na; WANG Zhi-Qiang; WANG Zong-Min; ZHANG Pu

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (10) : 787-789.

CLINICAL RESEARCH

Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation

XIA Li-Na, WANG Zhi-Qiang, WANG Zong-Min, ZHANG Pu

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Abstract

OBJECTIVE: To study the clinical significance of interstitial cell of Cajal (ICC) in spontaneous neonatal gastric perforation by examining the expression of c-kit and Cx43 in neonates with this disorder. METHODS: The gastric specimens of 19 cases of neonatal gastric perforation from 2001 to 2010 and 8 cases of accidental death without digestive tract malformations (control) were collected. Immunohistochemical staining was employed to examine the expression of c-kit and Cx43 (immunomarkers of ICCs) in gastric tissues. RESULTS: The muscular layer of the stomach wall became thinner or deficient in the gastric perforation group. C-kit and Cx43 positive cells in gastric tissues decreased significantly in the gastric perforation group compared with those in the control group (P＜0.01). CONCLUSIONS: The development of spontaneous neonatal gastric perforation is associated with the decreased quantity of ICCs and damaged gap junction structure of the stomach wall.

Key words

Spontaneous gastric perforation / Interstitial cell of Cajal / C-kit / Cx43 / Neonate

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XIA Li-Na, WANG Zhi-Qiang, WANG Zong-Min, ZHANG Pu. Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(10): 787-789

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