Clinical features and prognosis of t (8; 21)/AML1-ETO-positive childhood acute myeloid leukemia

WU Jun; ZHANG Le-Ping; LU Ai-Dong; WANG Bin; CHENG Yi-Fei; LIU Gui-Lan

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (12) : 931-935.

Clinical features and prognosis of t (8; 21)/AML1-ETO-positive childhood acute myeloid leukemia

WU Jun, ZHANG Le-Ping, LU Ai-Dong, WANG Bin, CHENG Yi-Fei, LIU Gui-Lan

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OBJECTIVE: To study the clinical and biological characteristics and prognosis of t(8;21)/AML1-ETO-positive childhood acute myeloid leukemia (AML). METHODS: The clinical data of 55 children who were diagnosed as t (8; 21)/AML1-ETO-positive AML were retrospectively studied. Event-free survival (EFS), disease-free survival (DFS), and overall survival (OS) rates were estimated by the Kaplan-Meier method. Prognostic factors were evaluated by COX regression analysis software. RESULTS: Of the 55 patients, 4 patients gave up treatment after the diagnosis was confirmed and 4 patients were lost to follow-up after the first chemotherapy course. The remaining 47 patients received a double-induction therapy. The total complete remission (CR) rate was 71% and 94% after the first and second chemotherapy course, respectively. The disease was relapsed in 10 patients (21%). The 5-year EFS, DFS and OS rates were (56.1±7.9)%, (59.8±8.1)%, and (72.0±8.1)%, respectively. Multivariate analysis showed that age was an independent risk factor for the long-term prognosis. The older children had a greater risk of experiencing an accident or death (P<0.05).The 5-year OS rate in 27 patients with regular consolidation chemotherapy was significantly higher than 13 patients with irregular chemotherapy after CR ［(47.5±17.1)% vs (38.9±17.3)%; P<0.01］. CONCLUSIONS: Childhood t(8;21)/AML1-ETO-positive AML is a highly heterogeneous disease, with a high CR rate and a good long-term prognosis. Age is one of the important factors affecting the long-term therapeutic effect. Regular consolidation chemotherapy applied after CR usually is helpful.

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Myeloid leukemia / Prognosis / Survival analysis / Child

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WU Jun, ZHANG Le-Ping, LU Ai-Dong, WANG Bin, CHENG Yi-Fei, LIU Gui-Lan. Clinical features and prognosis of t (8; 21)/AML1-ETO-positive childhood acute myeloid leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(12): 931-935

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