Serum levels of insulin-like growth factor-1 and growth factor binding protein-3 in children with acute lymphocytic leukemia

ZHAO  Dong-Ju; ZHANG  Wen-Lin; SHI  Tai-Xin

PDF(950 KB)

Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (2) : 101-103.

Serum levels of insulin-like growth factor-1 and growth factor binding protein-3 in children with acute lymphocytic leukemia

ZHAO Dong-Ju, ZHANG Wen-Lin, SHI Tai-Xin

Author information +

History +

Abstract

OBJECTIVE: To study serum levels and clinical significance of insulin-like growth factor-1 (IGF-1) and growth factor binding protein 3 (IGFBP-3) in children with acute lymphocytic leukemia (ALL). METHODS: Serum samples were obtained from 36 children with ALL before treatment and 6 months after complete remission. Thirty children with surgical diseases severed as the control group. Serum IGF-1 levels were measured using radioimmunoassay (RIA). Serum IGFBP-3 levels were measured using immunoradioassays (IRMA). RESULTS: Serum levels of IGF-1 and IGFBP-3 in the ALL group were 19±4 ng/mL and 1216±132 ng/mL, respectively before treatment, which were lower than those in the control group (32±3 ng/mL and 2104±191 ng/mL respectively) (P<0.01). Serum levels of IGF-1 and IGFBP-3 in the ALL group increased to 30±3 ng/mL and 1941±164 ng/mL respectively 6 months after complete remission, which were significantly higher than those before treatment (P<0.01) and were similar to the levels of the control group. CONCLUSIONS: Serum levels of IGF-1 and IGFBP-3 are reduced in children with ALL, but increase significantly after complete remission, suggesting that IGF-1 and IGFBP-3 might serve as useful markers for the diagnosis and evaluation of therapeutic effects of childhood ALL.

Key words

Insulin-like growth factor / Acute lymphocytic leukemia / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

ZHAO Dong-Ju, ZHANG Wen-Lin, SHI Tai-Xin. Serum levels of insulin-like growth factor-1 and growth factor binding protein-3 in children with acute lymphocytic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(2): 101-103

References

［1］Zhao MD, Hu XM, Sun DJ, Zhang Q, Zhang YH, Meng W. Expression of some tumor associated factors in human carcinogenesis and development of gastric carcinoma［J］. World J Gastroenterol, 2005, 11(21): 3217-3221. ［2］Zumkeller W. The insulin-like growth factor system in hematopoietic cells［J］. Leuk Lymphoma, 2002, 43(3): 487-491. ［3］中华医学会儿科学分会血液学组. 小儿急性淋巴细胞白血病诊疗建议（第二次修订草案）［J］.中华儿科杂志,1999, 37(5): 305-307. ［4］黄文斌, 周晓军.胰岛素样生长因子结合蛋白在人类恶性肿瘤中研究进展［J］.研究生学报,2005,18(2):156-160. ［5］Stromberg T, Ekman S, Girnita L, Dimberg LY, Larsson O, Axelson M, et al. IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2 /M-phase accumulation and apoptosis in multiple myeloma cells［J］.Blood, 2006, 107(2): 669-678. ［6］Ahlén J, Wejde J, Brosj-O, von Rosen A, Weng WH, Girnita L, et al.Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma［J］. Clin Cancer Res, 2005,11(1): 206-216. ［7］Serrano ML, Romero A, Cendales R,Sánchez-Gómez M, Bravo MM. Serum levels of insulin-like growth factor-I and -II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer［J］. Biomedica, 2006, 26(2): 258-268. ［8］Lu L, Katsaros D, Wiley A, Rigault de la Longrais IA, Risch HA, Puopolo M, et al. The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer［J］. Clin Cancer Res, 2006, 12(4):1208-1214. ［9］Sasaki J, Konishi F, Kawamura YJ, Kai T, Takata O, Tsukamoto T. Clinicopathological characteristics of colorectal cancers with loss of imprinting of insulinlike growth factor 2［J］. Int J Cancer, 2006, 119(1):80-83. ［10］Keehn CA, Saeed S, Bickle K, Khalil FK, Morgan MB. Expression of insulinlike growth factor-I receptor in primary cutaneous carcinomas［J］.J Cutan Pathol, 2004, 31(5):368-372. ［11］Argüelles B, Barrios V, Pozo J, Munoz MT, Argente J. Modifications of growth velocity and the insulin-like growth factor system in children with acute lyphoblastic leukemia: a longitudinal study［J］. J Clin Endocrinol Metab, 2000, 85(11):4087-4092. ［12］贺琪, 李晓, 陶英, 刘薏芝, 杨莲萍, 应韶旭. 胰岛素样生长因子I型受体在恶性血液病骨髓有核细胞的表达及其抗凋亡作用［J］. 中国实验血液学杂志,2005,13(3): 483-487.