Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura

WANG Xue-Ping; QIU Yun-Shu; HAO Guo-Ping; ZHU Lei

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (4) : 282-284.

CLINICAL RESEARCH

Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura

WANG Xue-Ping, QIU Yun-Shu, HAO Guo-Ping, ZHU Lei

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Abstract

OBJECTIVE: To study the levels of CD4+CD25+CD127- and CD3+CD4-CD8- regulatory T (Treg) cells in peripheral blood of children with idiopathic thrombocytopenic purpura (ITP). METHODS: The flow cytometry was used to detect the expression of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells in peripheral blood of 33 children with ITP and 21 healthy children. RESULTS: The expression levels of CD4+CD25+CD127-［(2.7±1.7)% vs (4.8±1.6)%; P<0.01］ and CD3+CD4-CD8-［(5.2±3.1)% vs (8.1±3.5)%; P<0.01］Treg cells in children with ITP were significantly lower than in the controls. CONCLUSIONS: The expression levels of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells decrease in children with ITP, suggesting that CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells might play a role in the pathogenesis of ITP.

Key words

Idiopathic thrombocytopenic purpura / CD4 antigen / CD25 antigen / CD8 antigen / Regulatory T cell / Child

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WANG Xue-Ping, QIU Yun-Shu, HAO Guo-Ping, ZHU Lei. Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(4): 282-284

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