Mobilization and collection of autologous peripheral blood stem cells by CIE or IEV protocol in children with malignant solid tumors

ZHANG Yi; ZHANG Wei-Ling; HUANG Dong-Sheng; YANG Yi-Ping; LIU Xiao-Chao; WU Yi-Ping

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (6) : 471-474.

Mobilization and collection of autologous peripheral blood stem cells by CIE or IEV protocol in children with malignant solid tumors

ZHANG Yi, ZHANG Wei-Ling, HUANG Dong-Sheng, YANG Yi-Ping, LIU Xiao-Chao, WU Yi-Ping

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Abstract

OBJECTIVE: Autologous peripheral blood stem cell transplantation (APBSCT) is an important method for treatment of malignant solid tumors in children. The mobilization and collection of blood stem cells is crucial for APBSCT. This study aimed to evaluate the clinical efficacy of mobilization and collection of blood stem cells by CIE or IEV chemotherapy protocol in APBSCT in children with neuroblastoma (NB) or rhabdomyosarcoma. METHODS: The protocols of CIE (cisplatin, etoposide) and IEV (vincristine, dosfamide, etoposide) were used as mobilization chemotherapy in 8 cases of NB with stage IV and 3 cases of rhabdomysacoma with stage III, respectively. The results of the mobilization of blood stem cells were observed. RESULTS: Of the 11 cases, mononuclear cells (MNC) and CD34+ cells were successfully collected and the volume of MNC and CD34 averaged (5.55±1.43)×108/kg and (4.88±2.48)×106/kg, respectively. No severe complications were observed during the mobilization and collection. A rapid hemopoietic reconstitution was observed in 10 children after APBSCT. One with NB out of the 10 children died of left heart failure 32 days after APBSCT. Others (9 cases) showed a nearly normal result of routine peripheral blood test 60 days after APBSCT. CONCLUSIONS: CIE or IEV protocol is effective and safe for the mobilization and collection of peripheral blood stem cells in children with NB or rhabdomysacoma.

Key words

Mobilization / Autologous peripheral blood stem cell / Neuroblastoma / Rhabdomyosarcoma / Child

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ZHANG Yi, ZHANG Wei-Ling, HUANG Dong-Sheng, YANG Yi-Ping, LIU Xiao-Chao, WU Yi-Ping. Mobilization and collection of autologous peripheral blood stem cells by CIE or IEV protocol in children with malignant solid tumors[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(6): 471-474

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