Left ventricular function in newborn infants of mothers with gestational diabetes mellitus

LIAO Wei-Qiang; ZHOU Huai-Yuan; CHEN Guan-Chun; ZOU Min; LV Xing

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (08) : 575-577.

CLINICAL RESEARCH

Left ventricular function in newborn infants of mothers with gestational diabetes mellitus

LIAO Wei-Qiang, ZHOU Huai-Yuan, CHEN Guan-Chun, ZOU Min, LV Xing

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Abstract

To evaluate left ventricular function in newborn infants of mothers with gestational diabetes mellitus (GDM). METHODS: Forty newborn infants of mother with GDM (GDM group) and forty normal newborn infants (control group) were enrolled in this study. Two-dimensional speckle tracking imaging was used to measure interventricular septal thickness, posterior left ventricular wall thickness and left ventricular ejection fraction in both groups. Left ventricular rotation and torsion were evaluated for all participants. RESULTS: Interventricular septal thickness in the GDM group was much higher than in the control group (0.45±0.06 mm vs 0.34±0.05 mm; P0.05). Peak subendocardial rotation, peak subepicardial rotation, peak bulk rotation and peak mural torsion were higher in the GDM group than in the control group (P<0.05). CONCLUSIONS: Cardiac function may be impaired in newborn infants of mothers with GDM, with changes in left ventricular shape and abnormalities of left ventricular rotation and torsion. However, infants have a normal ventricular blood ejection under the cardiac compensation. Two-dimensional speckle tracking imaging technique can be used for early detection of left ventricular function.

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Gestational diabetes mellitus / Left ventricular function / Newborn infant

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LIAO Wei-Qiang, ZHOU Huai-Yuan, CHEN Guan-Chun, ZOU Min, LV Xing. Left ventricular function in newborn infants of mothers with gestational diabetes mellitus[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(08): 575-577

References

［1］曹泽毅.中华妇产科学［M］.北京：人民卫生出版社，2000：508-509.

［2］储晨,桂永浩,任芸芸.测定脐血脑钠肽对血糖异常孕妇的胎儿心功能评价［J］.中国当代儿科杂志,2009,10(11):805-808.

［3］杨慧霞.妊娠期糖尿病的筛查与诊断［J］.中华围产医学杂志,2005,9(5):316-317.

［4］崔丽君,韩丽萍,乔彦霞,李彤娟.母亲妊娠合并糖尿病对新生儿血糖、胰岛素、胰岛素样生长因子-1的影响［J］.中国妇幼保健，2007,22（36）:5198-5199.

［5］Veille JC, Sivakoff M, Hanson R, Fanaroff AA. Interventricular septal thickness in fetuses of diabetic mothers ［J］. Obstet Gynecol, 1992, 79(1): 51-54.

［6］Kozák-Bárány A, Jokinen E, Kero P, Tuominen J, Ronnemaa T, Valimaki I. Impaired left ventricular diastolic function in newborn infants of mothers with pregestational or gestational diabetes with good glycemic control［J］. Early Hum Dev, 2004, 77(1-2): 13-22.

［7］Reller MD, Kaplan S. Hypertrophic cardiomyopathy in infants of diabetic mothers: an update［J］. Am J Perinatal, 1988, 5(4): 353-358.

［8］Gutgesell HP, Speer ME, Rosenberg HS. Characterization of the cardiomyophthy in infants of diabetic mothers［J］. Circulation, 1980, 61(2): 441-450.

［9］Chung J, Abraszewski P, Yu X, Liu W, Krainik AJ, Ashford M, et al. Paradoxical increase in ventricular torsion and systolic torsion rate in type 1 diabetic patients under tight glycemic control［J］. J Am Coll Cardiol, 2006, 47(2): 384-390.

［10］张芸,邓又斌,张清阳. 超声二维应变成像技术在评价扩张型心肌病患者左心收缩功能中的应用［J］. 中国超声医学杂志,2007,23(10):747-750.

［11］Taber LA, Yang M, Podazus WW. Mechanics of ventricular torsion［J］. J Biomech, 1996, 29 (6): 745-752.

［12］韩伟,谢明星,王新房,吕清,王静,张丽,等.超声斑点追踪显像技术评价健康人左室心肌整体和局部扭转运动特征的临床初步研究［J］.中国超声医学杂志，2008，8（24）:714-717.