Prognostic factors for hemophagocytic lymphohistiocytosis in children

LU Wen-Xian; LUO Jian-Ming

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (08) : 593-597.

CLINICAL RESEARCH

Prognostic factors for hemophagocytic lymphohistiocytosis in children

LU Wen-Xian, LUO Jian-Ming

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Abstract

OBJECTIVE: To study the main factors influencing prognosis of hemophagocytic lymphohistiocytosis (HLH) in children by summarizing the clinical features of HLH and investigating the relationship between relevant factors and prognosis. METHODS: The medical data of 63 children with HLH were retrospectively reviewed. Kaplan-Meier method was employed to draw survival curves. Factors influencing prognosis were assessed with Cox univariate analysis, and Cox multivariate analysis was done on statistically significant factors. RESULTS: The 3-year and 5-year survival rates were both 62.9%. The survival rate decreased from 98.4% at 1 day after definite diagnosis to 73.2% at 4 months. Univariate analysis demonstrated only one factor, which was that the condition of platelet recovery after treatment of 2 to 3 weeks was significantly related to prognosis (P=0.002). In children receiving etoposide therapy, temperature recovery after one day of treatment was significantly related to prognosis (P=0.016). CONCLUSIONS: Children with HLH have a satisfactory prognosis, but the survival rate reduces rapidly in the first 4 months after definite diagnosis. Platelet recovery after treatment of 2 to 3 weeks and temperature recovery after one day of treatment are factors influencing prognosis of HLH in children.

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Hemophagocytic lymphohistiocytosis / Prognosis / Child

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LU Wen-Xian, LUO Jian-Ming. Prognostic factors for hemophagocytic lymphohistiocytosis in children[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(08): 593-597

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