Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease

ZHANG He; LI Jiu-Jun

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (1) : 42-44.

CLINICAL RESEARCH

Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease

ZHANG He, LI Jiu-Jun

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Abstract

OBJECTIVE: To study the correlation between the blood serum brain natriuretic peptide (BNP) level and the left cardiac function in children with congenital heart disease (CHD). METHODS: The clinical data of 41 CHD children were retrospectively analyzed. Patients were divided into two groups based on the existence of congestive heart failure (CHF): CHD+CHF (n=21) and CHD alone (n=20). The blood serum BNP level was determined using chemiluminescence immunoassay, and the left ventricular ejection fraction (LVEF) was measured with echocardiogram. RESULTS: The serum BNP level was 1353 pg/mL (range: 926-2978) in the CHD+CHF group, which was significantly higher than in the CHD alone group［149 pg/mL (range: 75-242)］(P<0.01). The LVEF was 60% (range: 53%-65%) in the CHD+CHF group, which was significantly lower than in the CHD alone group［68% (range: 64%-72%)］(P<0.01). The serum BNP level showed a negative correlation with the LVEF level (r=-0.652, P<0.01). CONCLUSIONS: The blood serum BNP level is related to the cardiac function. For children with severe CHD+CHF, serum BNP level can be used as a sensitive indicator for evaluating cardiac function damage.

Key words

Congenital heart disease / Brain natriuretic peptide / Left ventricular ejection fraction / Heart failure / Child

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ZHANG He, LI Jiu-Jun. Correlation between the blood serum BNP level and the left cardiac function in children with congenital heart disease[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(1): 42-44

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