Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets

WANG Xiao-Yan; JIN Chun-Hua; WU Jian-Xin; LIU Zhuo; LI Mei; LI Na

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (10) : 767-770.

CLINICAL RESEARCH

Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets

WANG Xiao-Yan, JIN Chun-Hua, WU Jian-Xin, LIU Zhuo, LI Mei, LI Na

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Abstract

OBJECTIVE: To study the role of serum 25-hydroxyvitamin D in the early diagnosis of vitamin D deficiency rickets. METHODS: Concentrations of serum 25(OH)D, calcium, phosphorus and alkaline phosphatase were measured in normal control (n=73), suspected rickets (n=45) and confirmed rickets groups (n=65). Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum 25(OH)D for rickets. RESULTS: Serum 25(OH)D levels in the suspected and confirmed rickets groups were 83±30 and 72±31 nmol/L respectively, which was lower than in the normal control group (112±37 nmol/L) (P0.05). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group (P0.05). CONCLUSIONS: Serum 25(OH)D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25(OH)D levels in screening for rickets.

Key words

25-Hydroxyvitamin D / Vitamin D deficiency rickets / Infant

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WANG Xiao-Yan, JIN Chun-Hua, WU Jian-Xin, LIU Zhuo, LI Mei, LI Na. Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(10): 767-770

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