Value of neutrophil CD64 in the diagnosis of community acquired pneumonia in children

CAI Qun; XU Mei-Yu

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Chinese Journal of Contemporary Pediatrics ›› 2012, Vol. 14 ›› Issue (11) : 819-822.

Value of neutrophil CD64 in the diagnosis of community acquired pneumonia in children

CAI Qun, XU Mei-Yu

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Abstract

OBJECTIVE: To study the clinical value of the expression of neutrophil surface CD64 in the diagnosis of community acquired pneumonia in children. METHODS: Ninety-eight children with community acquired pneumonia were recruited into the study and were classified into three groups according to pathogene: bacterial pneumonia (n=48), viral pneumonia (n=29) and Mycoplasmal pneumonia (n=21). Twenty healthy children were enrolled as controls. The bacterial infection group was subdivided into mild infection (n=36) and severe infection groups (n=12). The levels of peripheral blood neutrophil CD64 were measured using flow cytometry. Dynamic changes of C-reactive protein were also detected for each patient. RESULTS: The CD64 index and CRP levels in the bacterial pneumonia group were significantly higher than in the other three groups (P<0.05). The CD64 index in the severe bacterial infection group was significantly higher than in the mild group (P<0.05). After antibiotic treatment, expression of CD64 in the severe bacterial infection group decreased significantly (P<0.05). The CD64 index was positively correlated with CRP value (r=0.545, P<0.01). ROC curve analysis showed that the threshold of CD64 and CRP was 2.8 and 8 mg/L respectively. Specificity of CD64 index (90%) was much higher than CRP (74%). CONCLUSIONS: The determination of peripheral blood neutrophil CD64 contributes to the early diagnosis of pulmonary bacterial infection and the evaluation of anti-infection effect.

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Community acquired pneumonia / CD64 / C-reactive protein / Child

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CAI Qun, XU Mei-Yu. Value of neutrophil CD64 in the diagnosis of community acquired pneumonia in children[J]. Chinese Journal of Contemporary Pediatrics. 2012, 14(11): 819-822

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