PDF(1222 KB)
Effect of atopy on serum glucocorticoid receptor levels in children with bronchiolitis
YAO Huan-Yin, LIU Wei-Rong, ZHANG Hang-Hu, LI Hua-Jun, WANG Xiao-Xian, LIU Shu-Mei, CHEN Xiao-Hong
Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (2) : 163-166.
PDF(1222 KB)
PDF(1222 KB)
Effect of atopy on serum glucocorticoid receptor levels in children with bronchiolitis
Objective To investigate the effect of atopy on the expression of glucocorticoid receptors in children with bronchiolitis. Methods ELISA was used to measure the changes in the serum levels of glucocorticoid receptor α (GRα) and glucocorticoid receptor β (GRβ) in the bronchiolitis group (77 children, including 34 children with atopy) and pneumonia group (68 children). Thirty-eight children who were prepared to undergo surgeries for non-infectious diseases and had no atopy or family history of allergic diseases were enrolled as the control group. Results The bronchiolitis group and the pneumonia group had significant increases in the serum levels of GRα and GRβ compared with the control group (P < 0.01), and the bronchiolitis group had significant increases in these levels compared with the pneumonia group (P < 0.01). Compared with the control group and the pneumonia group, the bronchiolitis group had a significant increase in the GRα/GRβ ratio (P < 0.01). Compared with the control group, the children with or without atopy in the bronchiolitis group had significant increases in the serum levels of GRα and GRβ (P < 0.01). The non-atopic children in the bronchiolitis group had a significant increase in the serum level of GRβ compared with the atopic children (P < 0.01). The atopic children in the bronchiolitis group had a significant increase in the GRα/GRβ ratio compared with the control group and non-atopic children in the bronchiolitis group (P < 0.01). Conclusions Children with bronchiolitis have increased serum levels of GRα and GRβ. The children with atopy have an increased GRα/GRβ ratio, suggesting that the atopic children with bronchiolitis are highly sensitive to glucocorticoids.
[1] McNaughten B,Bourke TW.Optimising the management of bronchiolitis in infants[J].Practitioner,2015,259(1784):13-15.
[2] Ochoa Sangrador C,González de Dios J;Research Group of the aBREVIADo Project.Overuse of bronchodilators and steroids in bronchiolitis of different severity:bronchiolitisstudy of variability,appropriateness,and adequacy[J].Allergol Immunopathol (Madr),2014,42(4):307-315.
[3] Tagarro A,Pérez L,Quintero VM,et al.Dexamethasone does not reduce length of hospitalization or recurrent wheezing 1 year after early bronchiolitis[J].Minerva Pediatr,2014,66(2):131-140.
[4] Plint AC,Grenon R,Klassen TP,et al.Bronchodilator and steroid use for the management of bronchiolitis in Canadian pediatric emergency departments[J].CJEM,2015,17(1):46-53.
[5] 王德全,王玉国,刘保国,等.糖皮质激素受体基因多态性与自身免疫性疾病相关性研究进展[J].河北医药,2015,37(12):1866-1868.
[6] 姚臻,莫炜明,赵善和,等.小剂量糖皮质激素吸入干预毛细支气管炎后反复喘息和哮喘发病率的临床观察[J].延边医学,2015,4(10):222-225.
[7] 张梓荆,申昆玲.毛细支气管炎[M].胡亚美,江载芳.诸福棠实用儿科学.第7版.北京:人民卫生出版社,2002:1199-1201.
[8] Reli? T,Ili? N,Kosti? G,et al.Respiratory syncytial virus infection and bronchial hyperreactivity in children up to two years of age in correlation with atopy[J].Vojnosanit Pregl,2016,73(1):59-65.
[9] Wang W,Huang KW,Wu BM,et al.Correlation of eosinophil counts in induced sputum and fractional concentration of exhaled nitric oxide and lung functions in patients with mild to moderate asthma[J].Chin Med J (Engl),2012,125(17):3157-3160.
[10] Webster Marketon JI,Corry J,Teng MN.The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation[J].Virology,2014,449:62-69.
[11] Fernandes RM,Hartling L.Glucocorticoids for acute viral bronchiolitis in infants and young children[J].JAMA,2014,311(1):87-88.
[12] Barnes PJ.Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease[J].J Allergy Clin Immunol,2013,131(3):636-645.
[13] Webster JI,Sternberg EM.Role of the hypothalamic-pituitaryadrenal axis,glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products[J].J Endocrinol,2004,181(2):207-221.
[14] Diaz PV,Pinto RA,Mamani R,et al.Increased expression of the glucocorticoid receptor β in infants with RSV bronchiolitis[J].Pediatrics,2012,130(4):804-811.
[15] 兰伟平,王婧,代传林,等.丙酸氟替卡松气雾剂或布地奈德混悬液干预对毛细支气管炎反复喘息的疗效观察[J].中国当代儿科杂志,2016,18(4):316-319.
[16] Lewis-Tuffin LJ,Cidlowski JA.The physiology of human glucocorticoid receptor beta (hGR beta) and glucocorticoid resistance[J].Ann N Y Acad Sci,2006,1069:1-9.
[17] 方丽萍,辛晓峰.激素抵抗型哮喘发病机制的研究进展[J].医学研究生学报,2013,26(10):1113-1116.
