Abstract:Objective To investigate the clinical symptoms and features of interictal epileptiform discharges (IED) on electroencephalogram (EEG) in children with spastic hemiplegic cerebral palsy (CP) and to analyze the risk factors for IED. Methods Eighty-three children with spastic hemiplegic CP were recruited, and their clinical data, results of video-electroencephalogram, imaging findings, and cognitive levels were collected. The influencing factors for IED were determined by multiple logistic regression analysis. Results The incidence of epilepsy was 13% in children with spastic hemiplegic CP; 34% of these cases had IED. The incidence of epilepsy in children with IED (32%) was significantly higher than that in those without IED (4%) (PPPPConclusions Spastic hemiplegic CP is often found with IED on EEG, and the incidence of epilepsy is higher in children with IED than in those without IED. Brain cortex impairment and low cognitive level have predictive values for IED in children with spastic hemiplegic CP.
LI Su-Yun,QIAN Xu-Guang,ZHAO Yi-Li et al. Risk factors for interictal epileptiform discharges on electroencephalogram in children with spastic hemiplegic cerebral palsy[J]. CJCP, 2015, 17(12): 1338-1341.
So EL. Interictal epileptiform discharges in persons without a history of seizures:what do they mean?[J]. J Clin Neurophysiol, 2010, 27(4):229-238.
[3]
Jaseja H, Jaseja B, Badaya S, et al. Treatment of interictal epileptiform discharges (IEDs) in patients with cerebral palsy for an improved prognostic outcome and quality of life:emerging evidence[J]. Epilepsy Behav, 2012, 25(3):473.
Engel Jr J; International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epilptic seizures and with epilepsy:report of the ILAE Task Force on Classification and Terminology[J]. Epilepsia, 2001, 42(6):796-803.
[7]
Zelnik N, Konopnicki M, Bennett-Back O, et al. Risk factors for epilepsy in children with cerebral palsy[J]. Eur J Paediatr Neurol, 2010, 14(1):67-72.
[8]
Sellier E1, Uldall P, Calado E, et al. Epilepsy and cerebral palsy: characteristics and trends in children born in 1976-1998[J]. Eur J Paediatr Neurol, 2012, 16(1):48-55.
[9]
El-Tallawy HN, Farghaly WM, Shehata GA, et al. Epileptic and cognitive changes in children with cerebral palsy:an Egyptian study[J]. Neuropsychiatr Dis Treat, 2014, 10:971-975.
Mert GG, Incecik F, Altunbasak S, et al. Factors affecting epilepsy development and epilepsy prognosis in cerebral palsy[J]. Pediatr Neurol, 2011, 45(2):89-94.
[14]
Wanigasinghe J, Reid SM, Mackay MT, et al. Epilepsy in hemiplegic cerebral palsy due to perinatal arterial ischaemic stroke[J]. Dev Med Child Neurol, 2010, 52(11):1021-1027.