氢质子磁共振波谱在新生儿缺氧缺血性脑病中的应用现状分析

邹蓉; 唐军; 鲍珊; 吴甜; 黄静兰; 屈艺; 母得志

doi:10.7499/j.issn.1008-8830.2018.06.004

PDF(1729 KB)

HTML

中国当代儿科杂志 ›› 2018, Vol. 20 ›› Issue (6) : 449-455. DOI: 10.7499/j.issn.1008-8830.2018.06.004

论著·临床研究

氢质子磁共振波谱在新生儿缺氧缺血性脑病中的应用现状分析

邹蓉, 唐军, 鲍珊, 吴甜, 黄静兰, 屈艺, 母得志

作者信息 +

Current status of the application of ¹H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy

ZOU Rong, TANG Jun, BAO Shan, WU Tian, HUANG Jing-Lan, QU Yi, MU De-Zhi

Author information +

文章历史 +

摘要

目的展现氢质子磁共振波谱（¹H-MRS）在新生儿缺氧缺血性脑病（HIE）中应用情况的研究现状，并描绘研究趋势。方法使用关键词及主题词在PubMed、EMBASE及Web of Science数据库检索2018年1月10日前发表的英文文献，通过严格的纳入及排除标准筛选文献。利用Excel 2016、Bicomb 2.0及VOSviewer1.6.6软件对关键词进行统计，并对热点词汇进行聚类分析及知识图谱绘制。结果共纳入文献66篇，提取高频关键词27个。结果显示，¹H-MRS在HIE中的应用主要集中在临床和科研两个方面的4个方向中。临床应用中，¹H-MRS作为HIE的临床检查手段及预后判断工具被广泛关注；在科研中，则主要应用于动物实验及与亚低温治疗相关的研究中。结论 ¹H-MRS作为磁共振成像的辅助手段，可在探究新生儿HIE的发病机制、优化现有治疗手段及判断患儿预后方面发挥作用。

Abstract

Objective To investigate the current status of the application of ¹H-magnetic resonance spectroscopy (¹H-MRS) in neonates with hypoxic-ischemic encephalopathy (HIE), and to describe the trend of research in the field. Methods PubMed, EMBASE, and Web of Science were searched for English articles published up to January 10, 2018, with the combination of key words and MeSH terms. The articles were screened according to inclusion and exclusion criteria. Excel 2016, Bicomb 2.0, and VOSviewer1.6.6 were used to analyze the key words, to perform a cluster analysis of hot words, and to plot the knowledge map. Results A total of 66 articles were included, and 27 high-frequency key words were extracted. The results showed that ¹H-MRS was mainly used in four directions of the clinical practice and scientific research on HIE. In clinical practice, ¹H-MRS attracted wide attention as a clinical examination for HIE and a tool for prognostic evaluation; in scientific research, ¹H-MRS was used in animal experiments and studies associated with mild hypothermia therapy. Conclusions As an auxiliary means of magnetic resonance imaging, ¹H-MRS plays an important role in investigating the pathogenesis of neonatal HIE, improving existing therapies, and evaluating the prognosis of neonates with HIE.

导出引用

邹蓉, 唐军, 鲍珊, 吴甜, 黄静兰, 屈艺, 母得志. 氢质子磁共振波谱在新生儿缺氧缺血性脑病中的应用现状分析[J]. 中国当代儿科杂志. 2018, 20(6): 449-455 https://doi.org/10.7499/j.issn.1008-8830.2018.06.004

ZOU Rong, TANG Jun, BAO Shan, WU Tian, HUANG Jing-Lan, QU Yi, MU De-Zhi. Current status of the application of ¹H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy[J]. Chinese Journal of Contemporary Pediatrics. 2018, 20(6): 449-455 https://doi.org/10.7499/j.issn.1008-8830.2018.06.004

参考文献

[1] Volpe JJ. Neonatal encephalopathy:an inadequate term for hypoxic-ischemic encephalopathy[J]. Ann Neurol, 2012, 72(2):156-166.
[2] Bonifacio SL, Devries LS, Groenendaal F. Impact of hypothermia on predictors of poor outcome:how do we decide to redirect care?[J]. Semin Fetal Neonatal Med, 2015, 20(2):122-127.
[3] Ment LR, Bada HS, Barnes P, et al. Practice parameter:neuroimaging of the neonate:report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society[J]. Neurology, 2002, 58(12):1726-1738.
[4] Cheong JL, Coleman L, Hunt RW, et al. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy:substudy of a randomized trial[J]. Arch Pediatr Adolesc Med, 2012, 166(7):634-640.
[5] Ghei SK, Zan E, Nathan JE, et al. MR imaging of hypoxic-ischemic injury in term neonates:pearls and pitfalls[J]. Radiographics, 2014, 34(4):1047-1061.
[6] Thayyil S, Chandrasekaran M, Taylor A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy:a meta-analysis[J]. Pediatrics, 2010, 125(2):e382-e395.
[7] Dabi Y, Darrigues L, Katsahian S, et al. Publication trends in bariatric surgery:a bibliometric study[J]. Obes Surg, 2016, 26(11):2691-2699.
[8] 包惠民, 李智. CNKI数据实现ucinet共现分析的方法及实证分析[J]. 软件导刊(教育技术), 2012, 11(1):91-93.
[9] Wang Y, Wang Q, Wei X, et al. Global scientific trends on exosome research during 2007-2016:a bibliometric analysis[J]. Oncotarget, 2017, 8(29):48460-48470.
[10] 储节旺, 郭春侠. EXCEL实现共词分析的方法——以国内图书情报领域知识管理研究为例[J]. 情报杂志, 2011, 30(3):45-49.
[11] 刘奕杉, 王玉琳, 李明鑫. 词频分析法中高频词阈值界定方法适用性的实证分析[J]. 数字图书馆论坛, 2017(9):42-49.
[12] Khalil GM, Gotway Crawford CA. A bibliometric analysis of U.S.-based research on the Behavioral Risk Factor Surveillance System[J]. Am J Prev Med, 2015, 48(1):50-57.
[13] Manias KA, Peet A. What is MR spectroscopy?[J]. Arch Dis Child Educ Pract Ed, 2017 Aug 26. pii:edpract-2017-312839. doi:10.1136/archdischild-2017-312839.[Epub ahead of print].
[14] Cheong JL, Cady EB, Penrice J, et al. Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury:metabolite peak-area ratios, relaxation times, and absolute concentrations[J]. AJNR Am J Neuroradiol, 2006, 27(7):1546-1554.
[15] Sijens PE, Wischniowsky K, Ter Horst HJ. The prognostic value of proton magnetic resonance spectroscopy in term newborns treated with therapeutic hypothermia following asphyxia[J]. Magn Reson Imaging, 2017, 42:82-87.
[16] Robertson NJ, Thayyil S, Cady EB, et al. Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy:from neuropathological correlates to future clinical applications[J]. Curr Pediatr Rev, 2014, 10(1):37-47.
[17] Alderliesten T, De Vries LS, Staats L, et al. MRI and spectroscopy in (near) term neonates with perinatal asphyxia and therapeutic hypothermia[J]. Arch Dis Child Fetal Neonatal Ed, 2017, 102(2):F147-F152.
[18] Ancora G, Testa C, Grandi S, et al. Prognostic value of brain proton MR spectroscopy and diffusion tensor imaging in newborns with hypoxic-ischemic encephalopathy treated by brain cooling[J]. Neuroradiology, 2013, 55(8):1017-1025.
[19] van Doormaal PJ, Meiners LC, ter Horst HJ, et al. The prognostic value of multivoxel magnetic resonance spectroscopy determined metabolite levels in white and grey matter brain tissue for adverse outcome in term newborns following perinatal asphyxia[J]. Eur Radiol, 2012, 22(4):772-778.
[20] Alderliesten T, de Vries LS, Benders M, et al. MR imaging and outcome of term neonates with perinatal asphyxia:value of diffusion-weighted MR imaging and 1H MR spectroscopy[J]. Radiology, 2011, 261(1):235-242.
[21] Ancora G, Soffritti S, Lodi R, et al. A combined a-EEG and MR spectroscopy study in term newborns with hypoxic-ischemic encephalopathy[J]. Brain Dev, 2010, 32(10):835-842.
[22] Berger HR, Brekke E, Wideroe M, et al. Neuroprotective treatments after perinatal hypoxic-ischemic brain injury evaluated with Magnetic Resonance Spectroscopy[J]. Dev Neurosci, 2017, 39(1-4):36-48.
[23] Azzopardi D, Edwards AD. Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy[J]. Semin Fetal Neonatal Med, 2010, 15(5):261-269.
[24] Pound P, Ebrahim S, Sandercock P, et al. Where is the evidence that animal research benefits humans?[J]. BMJ, 2004, 328(7438):514-517.
[25] Gunn AJ, Laptook AR, Robertson NJ, et al. Therapeutic hypothermia translates from ancient history in to practice[J]. Pediatr Res, 2017, 81(1-2):202-209.
[26] Wisnowski JL, Wu TW, Reitman AJ, et al. The effects of therapeutic hypothermia on cerebral metabolism in neonates with hypoxic-ischemic encephalopathy:an in vivo ¹H-MR spectroscopy study[J]. J Cereb Blood Flow Metab, 2016, 36(6):1075-1086.
[27] Owji ZP, Gilbert G, Saint-Martin C, et al. Brain temperature is increased during the first days of life in asphyxiated newborns:developing brain injury despite hypothermia treatment[J]. AJNR Am J Neuroradiol, 2017, 38(11):2180-2186.
[28] Wu TW, Mclean C, Friedlich P, et al. Brain temperature in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia[J]. J Pediatr, 2014, 165(6):1129-1134.
[29] Berger HR, Nyman A, Morken TS, et al. Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy[J]. PLoS One, 2017, 12(9):e185202.
[30] Azzopardi D, Robertson NJ, Bainbridge A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe):a proof-of-concept, open-label, randomised controlled trial[J]. Lancet Neurol, 2016, 15(2):145-153.