抗N-甲基-D-天门冬氨酸受体脑炎的病因学

乔娜娜; 孙若鹏

doi:10.7499/j.issn.1008-8830.2014.06.001

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中国当代儿科杂志 ›› 2014, Vol. 16 ›› Issue (6) : 567-570. DOI: 10.7499/j.issn.1008-8830.2014.06.001

抗NMDAR脑炎专题

抗N-甲基-D-天门冬氨酸受体脑炎的病因学

乔娜娜, 孙若鹏

作者信息 +

Etiology of anti-N-methyl-D-aspartate receptor encephalitis

QIAO Na-Na, SUN Ruo-Peng

Author information +

Department of Pediatrics, Qilu Hospital, Shandong University, Jinan 250012, China

Aboat authors:

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文章历史 +

摘要

抗N-甲基-D-天门冬氨酸受体（NMDAR）脑炎是近年来新认识的一种自身免疫性脑炎，儿童较多见。虽然对该病的认识不断加深，但其确切病因仍不明确。揭示抗NMDAR 脑炎的病因，对于进一步阐明该病的发病机制，深入认识该病，早期诊断并尽早启动相关免疫治疗从而改善预后是十分必要的。复习国内外文献，早期认为抗NMDAR 脑炎多与肿瘤尤其是畸胎瘤有关，随后的研究又发现其发病也与感染、遗传等因素等有关。该文对抗NMDAR 脑炎病因的认识及演变过程进行概述。

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a type of newly recognized autoimmune encephalitis which is commonly seen in children, but its precise etiology is still uncertain. To reveal the etiology of anti-NMDAR encephalitis is very necessary for understanding its pathology, and for starting immune-related therapy as early as possible to improve its prognosis. In the initial literature, tumor, especially teratoma is more related with the anti-NMDAR encephalitis. In recent research, its etiology is related to infection and heredity. This article reviews the recognition and variation of the etiology of anti-NMDAR encephalitis.

导出引用

乔娜娜, 孙若鹏. 抗N-甲基-D-天门冬氨酸受体脑炎的病因学[J]. 中国当代儿科杂志. 2014, 16(6): 567-570 https://doi.org/10.7499/j.issn.1008-8830.2014.06.001

QIAO Na-Na, SUN Ruo-Peng. Etiology of anti-N-methyl-D-aspartate receptor encephalitis[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(6): 567-570 https://doi.org/10.7499/j.issn.1008-8830.2014.06.001