Macronutrients and energy in milk from mothers of premature infants
HE Bi-Zi, SUN Xiu-Jing, QUAN Mei-Ying, WANG Dan-Hua
Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Abstract：Objective To study the dynamic changes in macronutrients and energy in human milk from mothers of premature infants. Methods A total of 339 human milk samples were collected from 170 women who delivered preterm or full-term infants in the Department of Obstetrics and Gynecology, Peking Union Medical College Hospital between November 2012 and January 2014. Macronutrients (proteins, fats and carbohydrates and energy were measured using a MIRIS human milk analyzer and compared between groups. Results In milk samples from premature infants' mothers, the protein levels were the highest in colostrum (2.22±0.49 g/dL), less in transitional milk (1.83±0.39 g/dL), and the least in mature milk (1.40±0.28 g/dL) (PPPPP+1-33+6 weeks and ≥34 weeks (2.48±0.68 g/dL vs 2.11±0.25 g/dL and 2.22±0.39 g/dL respectively, P+1-33+6 weeks (58±8 kcal/d; P+1-33+6 weeks and ≥34 weeks (P+1-33+6 weeks were significantly higher than those in mature milk from mothers of premature infants with gestational ages of ≤30 weeks and ≥34 weeks (PConclusions The levels of macronutrients and energy in milk from mothers of premature infants vary significantly between colostrum, transitional milk, and mature milk. Protein levels are significantly higher in colostrum from premature infants' mothers than in colostrum from term infants' mothers, but the significant difference is not seen for mature milk. Macronutrient and energy levels show significant differences between milk samples from mothers of premature infants with different gestational ages, so as to meet different needs of premature infants.
Gitte Z, Jesper FG, Mette VH. The content of macronutrients in milk from mothers of very preterm infants is highly variable[J]. Dan Med J, 2013, 60(6): A4613.
Hill PD, Aldag JC, Demirtas H, et al. Association of serum prolactin and oxytocin with milk production in mothers of preterm and term infants[J]. Biol Res Nurs, 2009, 10(4): 340-349.
[5]
Larios-Del YE, Vasquez-Garibay EM, Gonzalez-Ojeda, et al. A longitudinal evaluation of growth outcomes at hospital discharge of very-low-wight preterm infants[J]. Eur J Clin Nutr, 2012, 66(4): 474-480.
[6]
Faerk J, Skafte L, Petersen S. Macronutrients in milk from mothers delivering preterm[J]. Adv Exp Med Biol, 2001, 501(9): 409-413.
[7]
Olsen IE, Harris CL, Lawson L. Higher protein intake improve length, not weight, z-scores in preterm infants[J]. J Pediatr Gastroenterol Nutr, 2014, 58(4): 1097.
[8]
Arslanoglu S, Moro GE, Ziegler EE. et al. Optimization of human milk fortification for preterm infants:new concepts and recommendations[J]. J Perinat Med, 2010, 38(3): 233-238.
