Abstract：Objective To study the roles of chemokine receptor 3 (CXCR3) on lymphocytes and interferon-γ-inducible protein-10 (IP-10) of peripheral blood in childhood bronchiolitis. Methods Fifty-five children with bronchiolitis were classified into Group I (with allergic factors) and Group II (without allergic factors). Twenty-eight children with noninfectious diseases were enrolled randomly as the control group. The expression of CXCR3 (CD183 as its molecular marker) on lymphocytes of peripheral blood was detected by flow cytometry. Serum IP-10 level was measured using ELISA. Results The expression of CD183+ cells on CD4+ and CD8+ lymphocytes in peripheral blood in children with bronchiolitis from both Group I and Group II was significantly higher than that in the control group (P+ cells on CD4+ and CD8+ lymphocytes than Group II (PPConclusions CXCR3 and IP-10 are involved in the pathogenesis of bronchiolitis, and CXCR3 is associated with allergic factors.
ZOU LI-Ping,XU Xiu-Juan,ZHANG Yan et al. Roles of CXCR3 on lymphocytes and IP-10 of peripheral blood in infants with bronchiolitis[J]. CJCP, 2015, 17(2): 155-158.
Kim HH, Lee MH, Lee JS. Eosinophil cationic p rotein and che2 mokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis [J]. J Korean Med Sci, 2007, 22(1): 37242.
Sauty A, Dziejman M, Taha RA, et al. The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by aetivated human bronehial epithlial cells[J]. J Immunol, 1999, 162(6): 3549-3558.
