Abstract：Objective To explore the significance of interleukin-6(IL-6) and IL-8 in the diagnosis of neonatal sepsis. Methods This was a prospective study conducted between August 2014 and February 2015. A total of 140 neonates who were suspected infectious were enrolled and classified into a sepsis group (n=49) and a local infection group (n=91). Sixty-one neonates who were non-infectious served as the control group. Serum levels of IL-6 and IL-8 were measured before treatment and 3 days after treatment. The value of serum IL-6 and IL-8 for the diagnosis of neonatal sepsis was assessed by receiver operating characteristic (ROC) curve analysis. Results Before treatment, serum levels of IL-6 and IL-8 in the sepsis group were higher than those in the local infection and control groups (PPPPConclusions IL-6 and IL-8 participate in the inflammatory response and the serum levels of both vary with the severity of infection. The diagnostic value of IL-6 for neonatal sepsis is higher than IL-8. The combined detection of serum levels IL-6 and IL-8 may increase the accuracy of diagnosis of neonatal sepsis.
Meem M, Modak JK, Mortuza R, et al. Biomarkers for diagnosis of neonatal infections:A systematic analysis of their potential as a point-of-care diagnostics[J]. J Glob Health, 2011, 1(2):201-209.
Su H, Chang SS, Han CM, et al. Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis[J]. J Perinatol, 2014, 34(4): 268-274.
Shahkar L, Keshtkar A, Mirfazeli A, et al. The role of IL-6 for predicting neonatal sepsis:a systematic review and metaanalysis[J]. Iran J Pediatr, 2011, 21(4):411-417.
[12]
Boskabadi H, Maamouri G, Tavakol Afshari J, et al. Evaluation of serum interleukins-6, 8 and 10 levels as diagnostic markers of neonatal infection and possibility of mortality[J]. Iran J Basic Med Sci, 2013, 16(12):1232-1237.
[13]
Boskabadi H, Maamouri G, Afshari JT, et al. Serum interleukin 8 level as a diagnostic marker in late neonatal sepsis[J]. Iran J Pediatr, 2010, 20(1):41-47.
[14]
Kurokawa CS, Hashimoto M, de Souza Rugolo LM, et al. Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes[J]. Turk J Pediatr, 2013, 55(6):598-605.
[15]
Hatzidaki E, Gourgiotis D, Manoura A, et al. Interleukin-6 in preterm premature rupture of membranes as an indicator of neonatal outcome[J]. Acta Obstet Gynecol Scand, 2005, 84(7): 632-638.
