Correlation between neonatal vitamin D level and maternal vitamin D level
WANG Chen1, GAO Jin-Song2, YU Song-Lin3, QIU Ling3, ZENG Lin4, WANG Dan-Hua1
Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Abstract：Objective To investigate the correlation between neonatal and maternal vitamin D levels. Methods From June 1 to July 10, 2015, umbilical venous blood samples were collected from 102 full-term single neonates, and venous blood samples were collected from their mothers. Ultra-performance liquid chromatographywith isotope dilution was applied to measure the serum 25(OH)D level. Results Vitamin D insufficiency was found in 39 mothers (38.2%) and 27 neonates (26.5%), and vitamin D deficiency was found in 25 mothers (24.5%) and 66 neonates (64.7%). Neonatal serum 25(OH)D level differed significantly between the groups of mothers with different serum 25(OH)D levels (Pr=0.914, PCI: 0.930-0.994; PConclusions Neonatal vitamin D level is positively correlated with maternal vitamin D level. Maternal vitamin D level can help to predict neonatal vitamin D deficiency.
Dokos C, Tsakalidis C, Tragiannidis A, et al. Inside the "fragile" infant: pathophysiology, molecular background, risk factors and investigation of neonatal osteopenia[J]. Clin Cases Miner Bone Metab, 2013, 10(2): 86-90.
[2]
Kovacs CS. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies[J]. Am J Clin Nutr, 2008, 88(2): 520S-528S.
Institute of Medicine(US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D[M]. Washington, DC: The National Academies Press, 2011(www.ncbi.nlm.nih. gov/books/NBK56070/).
Lee JM, Smith JR, Philipp BL, et al. Vitamin D deficiency in a healthy group of mothers and newborn infants[J]. Clin Pediatr (Phila), 2007, 46(1): 42-44.
