努南综合征的生长发育规律与身材矮小的临床治疗进展

doi:10.7499/j.issn.1008-8830.2409047

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Abstract Patients with Noonan syndrome (NS) are born with normal or slightly lower body length and weight compared to the normal ranges. However, their height gradually falls behind that of the general population, leading to growth retardation and delayed puberty. In China, the incidence of short stature in patients with NS is approximately 65%. Short stature in these patients arises from multiple causes, including feeding difficulties in infancy, comorbidities such as congenital heart disease, genetic heterogeneity, and disorders of the growth hormone/insulin-like growth factor-1 axis. Growth hormone is commonly used to alleviate symptoms of short stature. This article reviews the growth and development patterns at different stages of NS, analyzes the causes of short stature, and summarizes the latest advances in treatment to provide new insights for the diagnosis and management of short stature in patients with NS.

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	Articles by authors
	LI Xin
	WEN Tian
	FENG Bi-Yun
	WANG Xiu-Min

Key words： Noonan syndrome Growth and development Short stature Growth hormone

Received: 09 September 2024

Corresponding Authors: Wang X-M,wangxiumin@scmc.com.cn。 E-mail: wangxiumin@scmc.com.cn

Cite this article:

LI Xin,WEN Tian,FENG Bi-Yun et al. Growth and development patterns of Noonan syndrome and advances in the treatment of short stature[J]. CJCP, 2025, 27(1): 33-38.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2409047 OR http://www.zgddek.com/EN/Y2025/V27/I1/33

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