Research advances in the effect of bioactive substances in breast milk on the growth and development of infants
ZHANG Meng, LI Wen-Xing, TANG Jun
Department of Pediatrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University), Ministry of Education, Chengdu 610041, China
Abstract There are various types of bioactive substances in human breast milk, such as active proteins, growth factors, cytokines, oligosaccharides, probiotics and cells. Many studies have shown that these bioactive substances in breast milk have important protective effects on infant growth and development, including anti-bacterial and anti-viral effects and the promotion of infant growth and development and immunologic maturation. They can also reduce the incidence rate of infectious diseases in infants, improve neural development in preterm infants, and reduce the risk of obesity and diabetes in future. However, there is still no clinical evidence for the effects of several active substances in breast milk, and their immunoregulatory mechanism remains unclear. Therefore, further studies are needed for clarification.
Li C, Solomons NW, Scott ME, et al. Minerals and trace elements in human breast milk are associated with guatemalan infant anthropometric outcomes within the first 6 months[J]. J Nutr, 2016, 146(10):2067-2074.
Gila-Diaz A, Arribas SM, Algara A, et al. A review of bioactive factors in human breastmilk:a focus on prematurity[J]. Nutrients, 2019, 11(6). pii:E1307.
Wada Y, Lonnerdal B. Bioactive peptides derived from human milk proteins-mechanisms of action[J]. J Nutr Biochem, 2014, 25(5):503-514.
Demmelmair H, Prell C, Timby N, et al. Benefits of lactoferrin, osteopontin and milk fat globule membranes for infants[J]. Nutrients, 2017, 9(8). pii:E817.
Donovan SM. Human milk proteins:composition and physiological significance[J]. Nestle Nutr Inst Workshop Ser, 2019, 90:93-101.
Le Doare K, Kampmann B. Breast milk and Group B streptococcal infection:vector of transmission or vehicle for protection?[J]. Vaccine, 2014, 32(26):3128-3132.
Suzuki K, Nakajima A. New aspects of IgA synthesis in the gut[J]. Int Immunol, 2014, 26(9):489-494.
Cacho NT, Lawrence RM. Innate immunity and breast milk[J]. Front Immunol, 2017, 8:584.
Wakabayashi H, Oda H, Yamauchi K, et al. Lactoferrin for prevention of common viral infections[J]. J Infect Chemother, 2014, 20(11):666-671.
de la Rosa G, Yang D, Tewary P, et al. Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses[J]. J Immunol, 2008, 180(10):6868-6876.
Drago-Serrano ME, Campos-Rodríguez R, Carrero JC, et al. Lactoferrin:balancing ups and downs of inflammation due to microbial infections[J]. Int J Molec Sci, 2017, 18(3):501.
Pammi M, Abrams SA. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants[J]. Cochrane Database Syst Rev, 2015, (2):CD007137.
Ochoa TJ, Zegarra J, Cam L, et al. Randomized controlled trial of lactoferrin for prevention of sepsis in peruvian neonates less than 2500 g[J]. Pediatr Infect Dis J, 2015, 34(6):571-576.
ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants:a randomised placebo-controlled trial[J]. Lancet, 2019, 393(10170):423-433.
Lindquist S, Hernell O. Lipid digestion and absorption in early life:an update[J]. Curr Opin Clin Nutr Metab Care, 2010, 13(3):314-320.
Casper C, Carnielli VP, Hascoet JM, et al. rhBSSL improves growth and LCPUFA absorption in preterm infants fed formula or pasteurized breast milk[J]. J Pediatr Gastroenterol Nutr, 2014, 59(1):61-69.
Naarding MA, Dirac AM, Ludwig IS, et al. Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells[J]. Antimicrob Agents Chemother, 2006, 50(10):3367-3374.
Shoji H, Shimizu T. Effect of human breast milk on biological metabolism in infants[J]. Pediatr Int, 2019, 61(1):6-15.
MohanKumar K, Namachivayam K, Ho TT, et al. Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis[J]. Semin Perinatol, 2017, 41(1):52-60.
Alzaree FA, AbuShady MM, Atti MA, et al. Effect of early breast milk nutrition on serum insulin-like growth factor-1 in preterm infants[J]. Open Access Maced J Med Sci, 2019, 7(1):77-81.
Lenhartova N, Matasova K, Lasabova Z, et al. Impact of early aggressive nutrition on retinal development in premature infants[J]. Physiol Res, 2017, 66(Suppl 2):S215-S226.
DiBiasie A. Evidence-based review of retinopathy of prematurity prevention in VLBW and ELBW infants[J]. Neonatal Netw, 2006, 25(6):393-403.
Hård AL, Nilsson AK, Lund AM, et al. Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk[J]. Acta Paediatr, 2019, 108(6):998-1007.
Rajani PS, Seppo AE, Jarvinen KM. Immunologically active components in human milk and development of atopic disease, with emphasis on food allergy, in the pediatric population[J]. Front Pediatr, 2018, 6:218.
Polat A, Tunc T, Erdem G, et al. Interleukin-8 and its receptors in human milk from mothers of full-term and premature infants[J]. Breastfeed Med, 2016, 11:247-251.
Peroni DG, Pescollderungg L, Piacentini GL, et al. Immune regulatory cytokines in the milk of lactating women from farming and urban environments[J]. Pediatr Allergy Immunol, 2010, 21(6):977-982.
Munblit D, Peroni DG, Boix-Amorós A, et al. Human milk and allergic diseases:an unsolved puzzle[J]. Nutrients, 2017, 9(8). pii:894.
Catli G, Anik A, Tuhan HÜ, et al. The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children[J]. Peptides, 2014, 56:72-76.
Woo JG, Guerrero ML, Guo F, et al. Human milk adiponectin affects infant weight trajectory during the second year of life[J]. J Pediatr Gastroenterol Nutr, 2012, 54(4):532-539.
Lemas DJ, Yee S, Cacho N, et al. Exploring the contribution of maternal antibiotics and breastfeeding to development of the infant microbiome and pediatric obesity[J]. Semin Fetal Neonatal Med, 2016, 21(6):406-409.
Timby N, Hernell O, Vaarala O, et al. Infections in infants fed formula supplemented with bovine milk fat globule membranes[J]. J Pediatr Gastroenterol Nutr, 2015, 60(3):384-389.
Andreas NJ, Kampmann B, Mehring Le-Doare K. Human breast milk:a review on its composition and bioactivity[J]. Early Hum Dev, 2015, 91(11):629-635.
Puccio G, Alliet P, Cajozzo C, et al. Effects of infant formula with human milk oligosaccharides on growth and morbidity:a randomized multicenter trial[J]. J Pediatr Gastroenterol Nutr, 2017, 64(4):624-631.
Donovan SM, Comstock SS. Human milk oligosaccharides influence neonatal mucosal and systemic immunity[J]. Ann Nutr Metab, 2016, 69(Suppl 2):42-51.
Ayechu-Muruzabal V, van Stigt AH, Mank M, et al. Diversity of human milk oligosaccharides and effects on early life immune development[J]. Front Pediatr, 2018, 6:239.
De Leoz ML, Kalanetra KM, Bokulich NA, et al. Human milk glycomics and gut microbial genomics in infant feces show a correlation between human milk oligosaccharides and gut microbiota:a proof-of-concept study[J]. J Proteome Res, 2015, 14(1):491-502.
Etzold S, Bode L. Glycan-dependent viral infection in infants and the role of human milk oligosaccharides[J]. Curr Opin Virol, 2014, 7:101-107.
Cruz D, Bazacliu C. Enteral feeding composition and necrotizing enterocolitis[J]. Semin Fetal Neonatal Med, 2018, 23(6):406-410.
Pannaraj PS, Li F, Cerini C, et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome[J]. JAMA Pediatr, 2017, 171(7):647-654.
Le Doare K, Holder B, Bassett A, et al. Mother's milk:a purposeful contribution to the development of the infant microbiota and immunity[J]. Front Immunol, 2018, 9:361.
Gomez-Gallego C, Garcia-Mantrana I, Salminen S, et al. The human milk microbiome and factors influencing its composition and activity[J]. Semin Fetal Neonatal Med, 2016, 21(6):400-405.
Maffei D, Schanler RJ. Human milk is the feeding strategy to prevent necrotizing enterocolitis![J]. Semin Perinatol, 2017, 41(1):36-40.
Maldonado J, Canabate F, Sempere L, et al. Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants[J]. J Pediatr Gastroenterol Nutr, 2012, 54(1):55-61.
Hassiotou F, Geddes DT. Immune cell-mediated protection of the mammary gland and the infant during breastfeeding[J]. Adv Nutr, 2015, 6(3):267-275.
Cabinian A, Sinsimer D, Tang M, et al. Transfer of maternal immune cells by breastfeeding:maternal cytotoxic T lymphocytes present in breast milk localize in the Peyer's patches of the nursed infant[J]. PLoS One, 2016, 11(6):e0156762.
Witkowska-Zimny M, Kaminska-El-Hassan E. Cells of human breast milk[J]. Cell Mol Biol Lett, 2017, 22:11.
Cregan MD, Fan Y, Appelbee A, et al. Identification of nestin-positive putative mammary stem cells in human breastmilk[J]. Cell Tissue Res, 2007, 329(1):129-136.
Patki S, Kadam S, Chandra V, et al. Human breast milk is a rich source of multipotent mesenchymal stem cells[J]. Hum Cell, 2010, 23(2):35-40.
Hassiotou F, Beltran A, Chetwynd E, et al. Breastmilk is a novel source of stem cells with multilineage differentiation potential[J]. Stem Cells, 2012, 30(10):2164-2174.
Hosseini SM, Talaei-Khozani T, Sani M, et al. Differentiation of human breast-milk stem cells to neural stem cells and neurons[J]. Neurol Res Int, 2014, 2014:807896.
Aydin MS, Yigit EN, Vatandaslar E, et al. Transfer and integration of breast milk stem cells to the brain of suckling pups[J]. Sci Rep, 2018, 8(1):14289.
Briere CE, McGrath JM, Jensen T, et al. Breast milk stem cells:current science and implications for preterm infants[J]. Adv Neonatal Care, 2016, 16(6):410-419.