Pathological study on therapy of pulmonary surfactant in the asthmatic model of guinea pigs
WEI Hong-Xia, FANG Feng, FANG Chao-Ping
Department of Pediatrics, Changhai Hospital, Shanghai 200433
Abstract Objective To observe the pathological changes in asthma after being treated with pulmonary surfactant (PS) dripped into the airway. Methods The asthmatic model was set up using guinea pigs immunized against ovalbumin. The pathological changes of bronchioles from five asthmatic animals and five treated ones were compared thirty minutes after the dripping of 0.3 ml PS into the airway. Results There were marked smooth muscle spasm, inflammatory cell infiltration and a large amount of exudate in the airway lumen in the asthma group. After being treated with PS, the inflammatory exudate disappeared and cell infiltration was alleviated. Conclusions Exterior PS could relieve spasm of bronchiole smooth muscle and alleviate airway inflammation.
Key words :
Asthma
Inflammation
Pathology
Pulmonary surfactant
Guinea pig
Cite this article:
WEI Hong-Xia,FANG Feng,FANG Chao-Ping. Pathological study on therapy of pulmonary surfactant in the asthmatic model of guinea pigs[J]. 中国当代儿科杂志, 1999, 1(3): 153-154.
WEI Hong-Xia,FANG Feng,FANG Chao-Ping. Pathological study on therapy of pulmonary surfactant in the asthmatic model of guinea pigs[J]. CJCP, 1999, 1(3): 153-154.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y1999/V1/I3/153
[1]
LEI Yuan, KUANG Shou-Jin, LIAO Cai-Shi. Effects of bacterial lysates and all trans-retinoic acid on airway inflammation in asthmatic mice [J]. CJCP, 2018, 20(6): 514-518.
[2]
PENG Jia-Yu, HUANG Ying, OU Jiang-Yan, YANG Yang. Association of blood lipids with childhood asthma [J]. CJCP, 2018, 20(6): 456-460.
[3]
XIU Xiao-Ying, CUI Yu-Xia, HUANG Yu-Ying, FAN Li, YUAN Jun, TIAN Zhu-Li. Association of vitamin D level with asthma control and pulmonary function in asthmatic children aged 4-12 years [J]. CJCP, 2018, 20(6): 461-464.
[4]
LIU Shu-Jun, WANG Ting-Ting, CAO Shi-Yu, TAN Ya-Qing, CHEN Li-Zhang. A Meta analysis of risk factors for asthma in Chinese children [J]. CJCP, 2018, 20(3): 218-223.
[5]
KE Li-Qin, WANG Feng-Mei, LUO Yun-Chun. Effects of vasoactive intestinal peptide on airway inflammation and Th17/Treg balance in asthmatic mice [J]. CJCP, 2017, 19(6): 699-704.
[6]
XU Xiao-Wen, HUANG Ying, WANG Jian, ZHANG Xue-Li, LIANG Fan-Mei, LUO Rong. Effect of obesity on pulmonary function in asthmatic children of different age groups [J]. CJCP, 2017, 19(5): 519-523.
[7]
ZHANG Hui-Qin, ZHANG Jing-Jing, LIU Yu-Dong, DENG Yue-Lin, LUO Jian-Feng, NIU Huan-Hong, SUN Xin. Application of pulmonary function and fractional exhaled nitric oxide tests in the standardized management of bronchial asthma in children [J]. CJCP, 2017, 19(4): 419-424.
[8]
WANG Jing, XIN Li-Hong, CHENG Wei, WANG Zhen, ZHANG Wen. Effect of heat shock factor 1 on airway hyperresponsiveness and airway inflammation in mice with allergic asthma [J]. CJCP, 2017, 19(2): 222-228.
[9]
FENG Shuai, CHEN Bo, YIN Xiao-Wen, LI Fang-Jun. Association between brain-derived neurotrophic factor and severity of asthma in children [J]. CJCP, 2017, 19(2): 167-170.
[10]
ZHU Xiao-Hua, LI Qiu-Gen, WANG Jun, HU Guo-Zhu, LIU Zhi-Qiang, HU Qing-Hua, WU Gang. Mechanism of action of BET bromodomain inhibitor JQ1 in treating airway remodeling in asthmatic mice [J]. CJCP, 2017, 19(12): 1278-1284.
[11]
ZHU Kang, HOU Xiao-Ling, HUANG Hui-Jie, WANG Ya-Ru, REN Yi-Xin, NI Xin, XIANG Li. Distribution characteristics of serum specific IgE for inhaled allergens in children with different airway allergic diseases [J]. CJCP, 2017, 19(11): 1185-1190.
[12]
ZHANG Hui-Qin, FAN Rui, ZHANG Jing-Jing, TAO Xiao-Juan, SUN Xin. Association between risk factors during maternal pregnancy and the neonatal period and childhood bronchial asthma [J]. CJCP, 2017, 19(1): 49-53.
[13]
WANG Li, ZHANG Yan-Li, WANG Xiu-Fang, SONG Zhe, WANG Wei. Expression and significance of mTOR/4EBP1/HIF-1α/VEGF signaling pathway in lung tissues of asthmatic mice [J]. CJCP, 2017, 19(1): 104-110.
[14]
QIAO Jun-Ying, SONG Li, ZHANG Yan-Li, LUAN Bin. HMGB1/TLR4/NF-κB signaling pathway and role of vitamin D in asthmatic mice [J]. CJCP, 2017, 19(1): 95-103.
[15]
WANG Zhen, WANG Jing, ZHANG Wen. Effect of triggering receptor expressed on myeloid cells 2 overexpression on airway inflammation and remodeling in mice with allergic asthma [J]. CJCP, 2016, 18(9): 879-884.