Abstract OBJECTIVE: To investigate the value of fractional nitric oxide concentration in exhaled breath (FeNO) in assessing the level of asthma control in children. METHODS: A total of 226 asthmatic children were divided into controlled asthma (n= 86), partially controlled asthma (n=63), and uncontrolled asthma groups (n=77). Ninety healthy children were enrolled as controls. FeNO was measured for both asthmatic and healthy children using the Swedish-designed NIOX system. RESULTS: The control group had an FeNO of 14±6 ppb, the controlled asthma group had an FeNO of 29±26 ppb, the partially controlled asthma group had an FeNO of 32±30 ppb, and the uncontrolled asthma group had an FeNO of 40±32 ppb. The three asthma groups showed significantly higher FeNO than the control group (P0.05). CONCLUSIONS: Asthmatic children have significantly higher FeNO than healthy children, and FeNO is correlated with the level of asthma control.
XIANG Li,FU YA-Nan,LI Zhen et al. Value of fractional nitric oxide concentration in exhaled breath in assessing level of asthma control in children[J]. CJCP, 2013, 15(1): 29-32.
XIANG Li,FU YA-Nan,LI Zhen et al. Value of fractional nitric oxide concentration in exhaled breath in assessing level of asthma control in children[J]. CJCP, 2013, 15(1): 29-32.
[1]Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications[J]. Am J Respir Crit Care Med, 2011, 184(5): 602-615.
[2]Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention[EB/OL]. Updated 2011. URL: http://www.ginasthma.org.
[7]Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics[J]. Eur Respir J, 1993, 6(9): 1368-1370.
[4]American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005[J]. Am J Respir Crit Care Med, 2005, 171(8): 912-930.
[8]Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, Anderson EL, et al. Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children[J]. J Allergy Clin Immunol, 2009, 124(5): 949-953.
[6]Cobos Barroso N, Pérez-Yarza EG, Sardón Prado O, Reverté Bover C, Gartner S, Korta Murua J. Exhaled nitric oxide in children: a noninvasive marker of airway inflammation[J]. Arch Bronconeumol, 2008, 44(1): 41-51.
[10]Franklin PJ, Turner SW, Le Souef PN, Stick SM. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children[J]. Thorax, 2003, 58(12): 1048-1052.
[7]Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics[J]. Eur Respir J, 1993, 6(9): 1368-1370.
[8]Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, Anderson EL, et al. Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children[J]. J Allergy Clin Immunol, 2009, 124(5): 949-953.
[14]Verini M, Consilvio NP, Di Pillo S, Cingolani A, Spagnuolo C, Rapino D, et al. FeNO as a marker of airways inflammation: the possible implications in childhood asthma management[J]. J Allergy (Cairo), 2010. Epub 2010 May 18.
[10]Franklin PJ, Turner SW, Le Souef PN, Stick SM. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children[J]. Thorax, 2003, 58(12): 1048-1052.
[15]Covar RA, Szefler SJ, Martin RJ, Sundstrom DA, Silkoff PE, Murphy J, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mildto-moderate asthma[J]. J Pediatr, 2003, 142(5): 469-475.
[16]Foley SC, Hopkins NO, Fitzgerald MX, Donnelly SC, McLoughlin P. Airway nitric oxide output is reduced in bronchiectasis[J]. Respir Med, 2007, 101(7): 1549-1555.
[14]Verini M, Consilvio NP, Di Pillo S, Cingolani A, Spagnuolo C, Rapino D, et al. FeNO as a marker of airways inflammation: the possible implications in childhood asthma management[J]. J Allergy (Cairo), 2010. Epub 2010 May 18.
[17]Shoemark A, Wilson R. Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis[J]. Respir Med, 2009, 103(5): 700-706.
[15]Covar RA, Szefler SJ, Martin RJ, Sundstrom DA, Silkoff PE, Murphy J, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mildto-moderate asthma[J]. J Pediatr, 2003, 142(5): 469-475.
[16]Foley SC, Hopkins NO, Fitzgerald MX, Donnelly SC, McLoughlin P. Airway nitric oxide output is reduced in bronchiectasis[J]. Respir Med, 2007, 101(7): 1549-1555.
[17]Shoemark A, Wilson R. Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis[J]. Respir Med, 2009, 103(5): 700-706.