Clinical effect of triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori infection in children

ZHAO Hong-Mei; OU-YANG Hong-Juan; DUAN Bo-Ping; XU Bin; CHEN Zhi-Yong; TANG Juan; YOU Jie-Yu

doi:10.7499/j.issn.1008-8830.2014.03.002

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (3) : 230-233. DOI: 10.7499/j.issn.1008-8830.2014.03.002

TOPIC OF DIGESTIVE DISEASES

Clinical effect of triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori infection in children

ZHAO Hong-Mei, OU-YANG Hong-Juan, DUAN Bo-Ping, XU Bin, CHEN Zhi-Yong, TANG Juan, YOU Jie-Yu

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Abstract

Objective To evaluate the clinical effect of proton pump inhibitor-based triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori (Hp) infection among children in terms of Hp eradication rate and incidence of adverse events. Methods A prospective randomised controlled study was conducted on 240 children with a confirmed diagnosis of Hp infection. These patients were randomized into triple therapy (n=120) and probiotics groups (n=120). The triple therapy group received amoxicillin [40 mg/(kg·d), Tid], clarithromycin [15 mg/(kg·d), Bid] and omeprazole [0.7-0.8 mg/(kg·d), Qd], while the probiotics group received Saccharomyces boulardii (250 mg, Bid) in addition to triple therapy. The course of treatment was 14 days in both groups. The adverse events in subjects were recorded by their parents during treatment. Hp eradiation was evaluated by ¹³C breath test at 4 weeks after treatment, and the eradication rate and incidence of adverse events were compared between the two groups. Results The Hp eradication rates were 75.8% (91/120) in the triple therapy group and 85% (102/120) in the probiotics group (P>0.05). Compared with the triple therapy group, the probiotics group had nonsignificantly lower incidence of nausea, vomiting, and abdominal pain (P>0.05) and significantly lower incidence of stomatitis, constipation and diarrhea (P<0.05). Conclusions Triple therapy combined with Saccharomyces boulardii cannot significantly increase Hp eradication rate, but can significantly reduce the incidence of stomatitis, constipation, and diarrhea during treatment.

Key words

Helicobacter pylori / Saccharomyces boulardii / Triple therapy / Child

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ZHAO Hong-Mei, OU-YANG Hong-Juan, DUAN Bo-Ping, XU Bin, CHEN Zhi-Yong, TANG Juan, YOU Jie-Yu. Clinical effect of triple therapy combined with Saccharomyces boulardii in the treatment of Helicobacter pylori infection in children[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(3): 230-233 https://doi.org/10.7499/j.issn.1008-8830.2014.03.002

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