Relationship between tight junction proteins and Helicobacter pylori-associated gastric diseases

LI Wei; JIANG Mi-Zu

doi:10.7499/j.issn.1008-8830.2014.03.005

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (3) : 242-247. DOI: 10.7499/j.issn.1008-8830.2014.03.005

TOPIC OF DIGESTIVE DISEASES

Relationship between tight junction proteins and Helicobacter pylori-associated gastric diseases

LI Wei, JIANG Mi-Zu

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Abstract

Helicobacter pylori (Hp) infection is an important cause of chronic gastritis and peptic ulcer, but their pathogenesis is unclear. The role of gastric mucosal barrier dysfunction induced by impaired structure and function of tight junction in the pathogenesis of Hp-associated gastric diseases has received considerable attention in recent years. Tight junction is composed of a variety of proteins and molecules, including 3 integral membrane proteins (occludin, claudins, and junctional adhesion molecules) and a cytoplasmic protein (zonula occludens). This paper mainly describes the composition and function of various tight junction proteins, changes in tight junction protein function induced by Hp infection and their relationship with the incidence of gastric diseases, and the significance of enhancing the tight junction protein function in the prevention and treatment of Hp-associated gastric diseases.

Key words

Helicobacter pylori / Tight junction protein / Gastric disease / Pathogenesis

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LI Wei, JIANG Mi-Zu. Relationship between tight junction proteins and Helicobacter pylori-associated gastric diseases[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(3): 242-247 https://doi.org/10.7499/j.issn.1008-8830.2014.03.005

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