Abstract Objective To study the prognostic significance of coagulation disorders in children with hemophagocytic syndrome (HPS). Methods Thirty-five children with HPS were retrospectively studied to analyze the etiology, clinical characteristics, laboratory results and treatment outcomes. Results After treatment, 27 of the 35 HPS patients survived, and the other 8 cases died. All cases were treated according to the HLH-2004 protocol, but etoposide (VP-16) was not used in 10 of them. The response rate in patients who received VP-16 (22/25, 88%) was significantly higher than that in those not receiving VP-16 (5/10, 50%) (PPPConclusions Coagulation function can be used as an indicator of disease outcome. It is essential for improving the clinical outcome of HPS to monitor the coagulation function during treatment, detect and correct abnormalities in time, and provide treatment strictly according to the HLH-2004 protocol.
GUO Jia,WANG Lu,HOU Wei-Na et al. Prognostic significance of coagulation disorders in children with hemophagocytic syndrome[J]. CJCP, 2014, 16(5): 504-507.
GUO Jia,WANG Lu,HOU Wei-Na et al. Prognostic significance of coagulation disorders in children with hemophagocytic syndrome[J]. CJCP, 2014, 16(5): 504-507.
Tseng YT, Sheng WH, Lin BH, et al. Causes, clinical symptoms,and outcomes of infectious disease associated with hemophagocytic lymphohistiocytosis in Taiwanese adults[J]. Microbiol Immunol Infect, 2011, 44(3): 191-197.
[6]
Karapinar B, Yilmaz D, Balkan C. An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit : hemophagocytic lymphohistiocytosis[J]. Pediatr Crit Care Med, 2009, 10(3): 285-290.
Degirmenci B, Miral S, Kaya GC, et al. Technetium-99m HMPAO brain SPECT in autistic children and their families[J]. Psychiatry Res, 2008, 162(3): 236-243.
[44]
Goldberg J, Anderson GM, Zwaigenbaum L, et al. Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders[J]. J Autism Dev Disord, 2009, 39(1): 97-104.
[13]
Zhuang JL, Jiang QW, Xu Y, et al. Recombinant activated factor Ⅶ in hemophagocytic lymphohistiocytosis with disseminated intravascular coagulation[J]. Chin Med J(Engl), 2011, 124(19): 3189-3191.
[45]
Rojas DC, Smith JA, Benkers TL, et al. Hippocampus and amygdala volumes in parents of children with autistic disorder [J]. Am J Psychiatry, 2004, 161(11): 2038-2044.
[14]
Yamamoto M, Hori T, Hatakeyama N, et al. Use of recombinant thrombomodulin in disseminated intravascular cogulation complicated hemophagocytic lymphohistiocytosis[J]. Indian J Pediatr, 2014, 81(3): 288-291.
[46]
Peterson E, Schmidt GL, Tregellas JR, et al. A voxel-based morphometry study of gray matter in parents of children with autism[J]. Neuroreport, 2006, 17(12): 1289-1292.
