Abstract Objective To study the relationship between nasal carriage and Staphylococcus aureus (S. aureus) infection in hospitalized children. Methods Fifty-six hospitalized children infected with S. aureus were recruited in this study. Nasal swabs were collected and cultured, and the nasal carriage rate of S. aureus was examined. PVL virulence gene and mecA resistance gene were both detected in clinical strains and nasal carriage strains by PCR. Results Twenty-two (39%) of the 56 children had nasal carriage of S. aureus, and most of them (18 cases) were younger than one year. Among these 22 children, 11 (50%) had previous hospitalization over the past year. In the infected strains, the rate of methicillin-resistant S. aureus (MRSA) was 29% (16/56), while it was 32% (7/22) in carriage strains. The mecA positive results in clinical strains were consistent with the results in nasal carriage strains. Among 5 PVL-positive nasal carriage strains, 4 (90%) could be matched with their clinical strains, all of which were MRSA. Conclusions Nasal carriage is a potential risk factor for S. aureus infection. Nosocomial transmission may lead to nasal carriage, which can cause S. aureus infection. The isolation rate of MRSA is high in hospitalized children infected with S. aureus, which implies that more attention is needed for this situation. The isolates from noses may be clonally identical to the isolates from clinical secretions, and the homology between them needs to be confirmed by multi-locus sequence typing.
About author:: 10.7499/j.issn.1008-8830.2015.04.001
Cite this article:
TAN Shan,WAN Chao-Min,DENG Jian-Jun et al. Epidemiological study on nasal carriage in hospitalized children infected with Staphylococcus aureus[J]. CJCP, 2015, 17(4): 299-302.
TAN Shan,WAN Chao-Min,DENG Jian-Jun et al. Epidemiological study on nasal carriage in hospitalized children infected with Staphylococcus aureus[J]. CJCP, 2015, 17(4): 299-302.
Werttheim HF, Vos MC, Ott A, et al. Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers [J]. Lancet, 2004, 364(9435): 703-705.
[2]
Wertheim HF, Melles DC, Vos MC, et al. The role of nasal carriage in Staphylococcus aureus infections[J]. Lancet Infect Dis, 2005, 5(12): 751-762.
[3]
Honda H, Krauss MJ, Coopersmith CM, et al. Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter?[J]. Infect Control Hosp Epidemiol, 2010, 31(6): 584-591.
Davis MF, Iverson S, Baron P, et al. Household transmission of meticillin-resistant Staphylococcus aureus and other staphylococci[J]. Lancet Infect Dis, 2012,12(9): 703-716.
[6]
Aslam N, Izhar M, Mehdi N. Frequency of methicillin-resistant Staphylococcus aureus nasal colonization among patients suffering from methicillin resistant Staphylococcus aureus bacteraemia[J]. Pak J Med Sci, 2013, 29(6): 1430-1432.
[7]
Kluytmans J. Reduction of surgical site infections in major surgery by elimination of nasal carriage of Staphylococcus aureus[J]. J Hosp Infect, 1998, 40(Suppl B): S25-S29.
