Abstract Objective To explore the expression and significance of the adhesion molecules CD62P and CD44 in the peripheral blood of infants with bronchiolitis. Methods Thirty-three infants with bronchiolitis in the acute phase and 19 infants with bronchiolitis in the recovery phase, who were hospitalized between November 2014 and May 2015, were enrolled. Thirty infants with bronchopneumonia and 26 infants without infection were enrolled as the bronchopneumonia group and the control group, respectively. The CD62P expression in the peripheral blood of each group was measured by flow cytometry, and the CD44 level in serum was determined using ELISA. Results The levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the acute phase were significantly higher than those in the bronchiolitis group in the recovery phase, the bronchopneumonia group, and the control group (PPr=0.91; PConclusions The adhesion molecules CD62P and CD44 play an important role in the pathogenesis of bronchiolitis, and their levels can reflect the severity of inflammatory response in infants with bronchiolitis.
About author:: 10.7499/j.issn.1008-8830.2015.11.010
Cite this article:
ZOU Li-Ping,WANG Wei,ZHANG Yan-Li et al. Expression and significance of adhesion molecules CD62P and CD44 in peripheral blood of infants with bronchiolitis[J]. CJCP, 2015, 17(11): 1200-1203.
ZOU Li-Ping,WANG Wei,ZHANG Yan-Li et al. Expression and significance of adhesion molecules CD62P and CD44 in peripheral blood of infants with bronchiolitis[J]. CJCP, 2015, 17(11): 1200-1203.
Johansson MW. Activation states of blood eosinophils in asthma[J]. Clin Exp Allergy, 2014, 44(4): 482-498.
[5]
Tamagawa-Mineoka R. Important roles of platelets as immune cells in the skin[J]. J Dermatol Sci, 2015, 77(2): 93-101.
[6]
Nasti TH, Bullard DC, Yusuf N. P-selectin enhances growth and metastasis of mouse mammary tumors by promoting regulatory T cell infiltration into the tumors[J]. Life Sci, 2015, 131(10): 11-18.
[7]
Bielinski SJ, Berardi C, Decker PA, et al. P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)[J]. Atherosclerosis, 2015, 240(1): 3-9.
[8]
Johansson MW, Han ST, Gunderson KA, et al. Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma[J]. Am J Respir Crit Care Med, 2012, 185(5): 498-507.
Sommer W, Knöfel AK, Madrahimov N, et al. Allogeneic CD4+CD25high T cells regulate obliterative bronchiolitis of heterotopic bronchus allografts in both porcinized and humanized mouse models[J]. Transplantation, 2015, 99(3): 482-491.
[11]
Brand HK, Ferwerda G, Preijers F, et al. CD4+T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection[J]. Pediatr Res, 2013, 73(2): 187-193.
[12]
Pardo J, Panizo A, Sola I, et al. Prognostic value of clinical, morphologic, and immunohistochemical factors in patients with bronchiolitis obliterans-organizing pneumonia[J]. Hum pathol, 2013, 44(5): 718-724.
[13]
Ezzelarab MB, Liu YW, Lin CC, et al. Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells[J]. Xenotransplantation, 2014, 21(1): 16-24.
[14]
Rosencher J, Zuily S, Varenne O, et al. Acute myocardial infarction secondary to platelet apheresis in a 57-year healthy donor[J]. Int J Cardiol, 2011, 150(3): 119-120.
[15]
Johansson MW, Han ST, Gunderson KA, et al. Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma[J]. Am J Respir Crit Care Med, 2012, 185(1): 498-507.
[16]
Benton AS, Kumar N, Lerner J, et al. Airway platelet activation is associated with airway eosinophilic inflammation in asthma[J]. J Investig Med, 2010, 58(8): 987-990.
[17]
Yang C, Liang H, Zhao H, et al. CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients[J]. Exp Ther Med, 2012, 4(1): 79-83.
