Abstract Objective To investigate the changes of the levels of galectin-3(Gal-3) in serum and bronchoalveolar lavage fluid (BALF) of children with asthma whose have different serum levels of 25-hydroxyl-vitamin D3[25(OH)D3]. Methods Fifty children with asthma between January 2013 and December 2014 were enrolled as the asthma group, and they were classified into 25(OH)D3 sufficient (n=7), insufficient (n=12) and deficient subgroups (n=31) according to the serum levels of 25(OH)D3. Twenty children with abnormal airway or tracheal foreign bodies served as the control group. The levels of 25(OH)D3, Gal-3 and total IgE in serum and Gal-3 levels in BALF were measured using ELISA. Results The serum levels of 25(OH)D3 in the asthma group were lower than in the control group (PPPPPConclusions The children with asthma have low serum levels of 25(OH) D3. 25(OH) D3 and Gal-3 may be involved in the airway inflammation and the development of asthma.
JIANG Kun,LU Xiao-Xia,WANG Ying et al. Relationship between serum 25-hydroxyl-vitamin D3 levels and galectin-3 levels in serum and bronchoalveolar lavage fluid in children with asthma[J]. CJCP, 2015, 17(12): 1301-1305.
JIANG Kun,LU Xiao-Xia,WANG Ying et al. Relationship between serum 25-hydroxyl-vitamin D3 levels and galectin-3 levels in serum and bronchoalveolar lavage fluid in children with asthma[J]. CJCP, 2015, 17(12): 1301-1305.
Iqbal SF, Freishtat RJ. Mechanism of action of vitamin D in the asthmatic lung[J]. J Investig Med, 2011, 59(8):1200-1202.
[2]
Saegusa J, Hsu DK, Chen HY, et al. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis[J]. Am J Pathol, 2009, 174(3):922-931.
[3]
Dorsch MP, Nemerovski CW, Ellingrod VL, et al. Vitamin D receptor genetics on extracellular matrix biomarkers and hemodynamics in systolic heart failure[J]. J Cardiovasc Pharmacol Ther, 2014, 19(5):439-445.
[4]
Aubin JE, Gupta AK, Bhargava U, et al. Expression and regulation of galectin 3 in rat osteoblastic cells[J]. J Cell Physiol, 1996, 169(3):468-480.
3.0.CO;2-M target="_blank">
Holick MF. Vitamin D deficiency[J]. N Engl J Med, 2007, 357(3):266-281.
[7]
Reichel H, Koeffler HP, Norman AW, et al. The role of the vitamin D endocrine system in health and disease[J]. N Engl J Med, 1989, 320(15):980-991.
[8]
Brehm JM, Schuemann B, Fuhlbrigge AL, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study[J]. J Allergy Clin Immunol, 2010, 126(1):52-58.
[9]
Martineau AR, Timms PM, Bothamley GH, et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis:a double-blind randomised controlled trial[J]. Lancet, 2011, 377(9761):242-250.
[10]
Uysalol M, Mutlu LC, Saracoglu GV, et al. Childhood asthma and vitamin D deficiency in Turkey:is there cause and effect relationship between them?[J]. Ital J Pediatr, 2013, 39:78.
[11]
Bener A, Ehlayel MS, Tulic MK, et al. Vitamin D deficiency as a strong predictor of asthma in children[J]. Int Arch Allergy Immunol, 2012, 157(2):168-175.
Trujillo G, Habiel DM, Ge L, et al. Neutrophil recruitment to the lung in both C5a-and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice[J]. J Immunol, 2013, 191(2):848-856.
[16]
Hirsch D, Archer FE, Joshi-Kale M, et al. Decreased antiinflammatory responses to vitamin D in neonatal neutrophils[J]. Mediators Inflamm, 2011, 2011:598345.
MacKinnon AC, Farnworth SL, Hodkinson PS, et al. Regulation of alternative macrophage activation by galectin-3[J]. J Immunol, 2008, 180(4):2650-2658.
[19]
Fattouh R, Jordana M. TGF-beta, eosinophils and IL-13 in allergic airway remodeling:a critical appraisal with therapeutic considerations[J]. Inflamm Allergy Drug Targets, 2008, 7(4): 224-236.
[20]
Rao SP, Wang Z, Zuberi RI, et al. Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow[J]. J Immunol, 2007, 179(11):7800-7807.
