Abstract Objective To compare the epidemiological and clinical features of lower respiratory tract infection(LRTI) caused by influenza virus A(IVA) and influenza virus B(IVB) in children.Methods The clinical data of 366 children with LRTI caused by influenza virus(IV), who were hospitalized in Yuying Children's Hospital of Wenzhou Medical University between 2010 and 2014, were analyzed retrospectively, and there were 272 cases caused by IVA and 94 cases caused by IVB.Results IV was mainly prevalent from December to March of the next year, with the predominance of IVA.There were small peaks of IVA prevalence in July or September every other year, and IVB was prevalent from December to March of the next year every other year.The children with LRTI caused by IVA alone had a significantly higher white blood cell(WBC) count and significantly higher percentages of children with increased WBC, abnormal serum sodium, and abnormal serum potassium than those caused by IVB alone(PP>0.05).The rate of co-infection with respiratory syncytial virus(RSV) was significantly higher in the IVB group than in the IVA group(PConclusions IVA is prevalent in winter and spring every year and has small peaks in summer every other year, while IVB is prevalent in winter and spring every other year.Compared with IVB, IVA causes more cases of increased WBC and electrolyte disturbance.The children infected with IVB are more likely to be co-infected with RSV.The children with LRTI caused by IVA and IVB have similar clinical manifestations.
ZHONG Pei-Pei,ZHANG Hai-Lin,CHEN Xiao-Fang et al. Lower respiratory tract infection caused by influenza virus A and influenza virus B in Wenzhou, China: a clinical analysis of 366 children[J]. CJCP, 2016, 18(2): 117-122.
ZHONG Pei-Pei,ZHANG Hai-Lin,CHEN Xiao-Fang et al. Lower respiratory tract infection caused by influenza virus A and influenza virus B in Wenzhou, China: a clinical analysis of 366 children[J]. CJCP, 2016, 18(2): 117-122.
Tallo VL, Kamigaki T, Tan AG, et al. Estimating influenza outpatients' and inpatients' incidences from 2009 to 2011 in a tropical urban setting in the Philippines[J]. Influenza Other Respir Viruses, 2014, 8(2):159-168.
[6]
Mainassara HB, Lagare A, Tempia S, et al. Influenza Sentinel Surveillance among Patients with Influenza-Like-Illness and Severe Acute Respiratory Illness within the Framework of the National Reference Laboratory, Niger, 2009-2013[J]. PLoS One, 2015, 10(7):e0133178.
[7]
Moineddin R, Nie JX, Domb G, et al. Seasonality of primary care utilization for respiratory diseases in Ontario:a time-series analysis[J]. BMC Health Serv Res, 2008, 8(Special):1-6.
[8]
Caini S, Huang QS, Ciblak MA, et al. Epidemiological and virological characteristics of influenza B:results of the Global Influenza B Study[J]. Influenza Other Respir Viruses, 2015, 9(Suppl 1):3-12.
[9]
Puig-Barbera J, Tormos A, Trushakova S, et al. The Global Influenza Hospital Surveillance Network(GIHSN):A new platform to describe the epidemiology of severe influenza[J]. Influenza Other Respir Viruses, 2015, 9(6):277-286.
Paddock CD, Liu L, Denison AM, et al. Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection[J]. J Infect Dis, 2012, 205(6):895-905.
[12]
Kessaram T, Stanley J, Baker MG. Estimating influenzaassociated mortality in New Zealand from 1990 to 2008[J]. Influenza Other Respir Viruses, 2015, 9(1):14-19.
[13]
Leung CH, Tseng HK, Wang WS, et al. Clinical characteristics of children and adults hospitalized for influenza virus infection[J]. J Microbiol Immunol Infect, 2014, 47(6):518-525.
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic(H1N1) 2009 Influenza. Clinical aspects of pandemic 2009 influenza A(H1N1) virus infection[J]. N Engl Med, 2010, 362(18):1708-1719.
Wu Y, Tu W, Lam KT, et al. Lethal coinfection of influenza virus and Streptococcus pneumoniae lowers antibody response to influenza virus in lung and reduces numbers of germinal center B cells, T follicular helper cells,and plasma cells in mediastinal lymph node[J]. J Virol, 2015, 89(4):2013-2023.
