Abstract Objective To observe the levels of pulmonary surfactant proteins A and D (SP-A, SP-D) in bronchoalveolar lavage fluid (BALF) of children with pneumonia, and to explore their relationships with clinical characteristics. Methods Thirty-five children with pneumonia were enrolled in this study. Differential cell counts were obtained by Countstar counting board. The levels of SP-A and SP-D in BALF were detected using ELISA. Results In children with pneumonia, SP-D levels were significantly higher than SP-A levels (Prs=-0.5255, P8 mg/L) were significantly lower than in those with a normal level of C-reactive protein (PPConclusions SP-D levels in BALF are significantly higher than SP-A levels, and have a certain correlation with clinical characteristics in children with pneumonia. As a protective factor, SP-D plays a more important role than SP-A in regulating the immune and inflammatory responses.
WANG Li-Li,ZHENG Shou-Yan,REN Luo et al. Levels of surfactant proteins A and D in bronchoalveolar lavage fluid of children with pneumonia and their relationships with clinical characteristics[J]. CJCP, 2016, 18(5): 386-390.
WANG Li-Li,ZHENG Shou-Yan,REN Luo et al. Levels of surfactant proteins A and D in bronchoalveolar lavage fluid of children with pneumonia and their relationships with clinical characteristics[J]. CJCP, 2016, 18(5): 386-390.
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