Abstract Objective To investigate the clinical efficacy of compound glycyrrhizin tablets in the treatment of children with nonalcoholic fatty liver disease. Methods A total of 65 children with nonalcoholic fatty liver disease between June 2014 and May 2016 were randomly divided into two groups:compound glycyrrhizin tablets treatment (n=33) and liver-protecting tablets treatment (n=32). The course of treatment was 24 weeks for both groups. The serum levels of alanine aminotransferase, gamma-glutamyl transpeptidase, hyaluronic acid, procollagen type III, type IV collagen, and laminin were measured before and after treatment for both groups. Results There was a significant difference in the overall response rate between the compound glycyrrhizin tablets treatment and liver-protecting tablets treatment groups (85% vs 50%; P P P Conclusions Compound glycyrrhizin tablets can effectively improve hepatic function and reduce serum levels of liver fibrosis markers in children with nonalcoholic fatty liver disease and have a better clinical efficacy than liver-protecting tablets.
LI Yu-Wen,HU Yu-Hua,ZHU Tian-Tian et al. Clinical efficacy of compound glycyrrhizin tablets in the treatment of children with nonalcoholic fatty liver disease[J]. CJCP, 2017, 19(5): 505-509.
LI Yu-Wen,HU Yu-Hua,ZHU Tian-Tian et al. Clinical efficacy of compound glycyrrhizin tablets in the treatment of children with nonalcoholic fatty liver disease[J]. CJCP, 2017, 19(5): 505-509.
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