Abstract Objective To summarize the extraintestinal manifestations and intestinal complications in children with Crohn's disease (CD). Methods The clinical data of 54 children who were diagnosed with CD in Peking Union Medical College Hospital from January 2008 to December 2018 were collected for retrospective analysis of extraintestinal manifestations and intestinal complications. According to the location of the lesion, the children were divided into ileocolonic group (30 cases), colonic group (6 cases), and ileal group (18 cases). Results In the 54 children, the mean age at diagnosis was 14.5±2.7 years, and the median duration from disease onset to definite diagnosis was 20 months (range:1-36 months). Twenty-four patients (44%) had extraintestinal manifestations, with the two most common manifestations being growth retardation (11 cases, 20%) and oral mucosal ulcer (10 cases, 19%), followed by arthritis (2 cases, 4%), erythema nodosum (2 cases, 4%), and cholecystitis (2 cases, 4%). There were no significant differences in the incidence of extraintestinal manifestations among the three groups (P=0.792). The most common intestinal complications were anal fistula/perianal abscess (13 cases, 24%), followed by intestinal fistula (5 cases, 9%) and intestinal obstruction (4 cases, 7%). There was a significant difference in the incidence of intestinal complications among the three groups (P=0.0406). No intestinal complications were reported in the colonic group. Conclusions Extraintestinal manifestations and intestinal complications are common in children with CD. Perianal examinations should be performed in children with suspected CD. Intestinal complications are less common in children with colonic CD, which may be associated with relatively mild disease condition.
TANG Xiao-Yan,LI Zheng-Hong,DONG Mei et al. Extraintestinal manifestations and intestinal complications in children with Crohn's disease: an analysis of 54 cases[J]. CJCP, 2020, 22(5): 478-481.
TANG Xiao-Yan,LI Zheng-Hong,DONG Mei et al. Extraintestinal manifestations and intestinal complications in children with Crohn's disease: an analysis of 54 cases[J]. CJCP, 2020, 22(5): 478-481.
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