Antibiotic use in very low birth weight/extremely low birth weight infants in 15 hospitals in Jiangsu Province of China: a multicenter survey
ZHAO Juan-Juan, HAN Shu-Ping, YU Zhang-Bin, PAN Zhao-Juan, ZHOU Qin, JIANG Shan-Yu, WAN Jun, ZHANG Lin, WANG Huai-Yan, MENG Meng, XU Yan, CHEN Xiao-Qing, XUE Mei, YANG Li, WU Ming-Fu, GU Li, LU Hong-Yan, QIAO Yu, WU Xin-Ping, GU Chuan-Li, HOU Wei-Wei, GAO Yan, YANG Shou-Hong, ZHANG Ji-Hua, LIU Song-Lin
Department of Neonatology, Women's Hospital of Nanjing Medical University/Nanjing Maternity and Child Health Care Hospital, Nanjing 210004 (Yu Z-B, Email: zhangbinyu@njmu.edu.cn)
Abstract Objective To investigate the current status of antibiotic use in very low birth weight/extremely low birth weight infants in Jiangsu Province of China, and to provide a clinical basis for the quality and improvement of antibiotic management in the neonatal intensive care unit (NICU). Methods A retrospective analysis was performed on the data on general conditions and antibiotic use in the very low birth weight/extremely low birth weight infants who were admitted to 15 hospitals of Jiangsu Province from January 1, 2019 to December 31, 2020. A questionnaire containing 10 measures to reduce antibiotic use was designed to investigate the implementation of these intervention measures. Results A total of 1 920 very low birth weight/extremely low birth weight infants were enrolled, among whom 1 846 (96.15%) were treated with antibiotic, and the median antibiotic use rate (AUR) was 50/100 patient-days. The AUR ranged from 24/100 to 100/100 patient-days in the 15 hospitals. After adjustment for the confounding factors including gestational age, birth weight, and neonatal critical score, the Poisson regression analysis showed that there was a significant difference in the adjusted AUR (aAUR) among the hospitals (P<0.01). The investigation results showed that among the 10 measures to reduce antibiotic use, 8 measures were implemented in less than 50% of these hospitals, and the number of intervention measures implemented was negatively correlated with aAUR (rs=-0.564, P=0.029). Conclusions There is a high AUR among the very low birth weight/extremely low birth weight infants in the 15 hospitals of Jiangsu Province, with a significant difference among hospitals. The hospitals implementing a relatively few measures to reduce antibiotic use tend to have a high AUR. It is expected to reduce AUR in very low birth weight/extremely low birth weight infants by promoting the quality improvement of antibiotic use management in the NICU. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(9): 988-993
ZHAO Juan-Juan,HAN Shu-Ping,YU Zhang-Bin et al. Antibiotic use in very low birth weight/extremely low birth weight infants in 15 hospitals in Jiangsu Province of China: a multicenter survey[J]. CJCP, 2022, 24(9): 988-993.
ZHAO Juan-Juan,HAN Shu-Ping,YU Zhang-Bin et al. Antibiotic use in very low birth weight/extremely low birth weight infants in 15 hospitals in Jiangsu Province of China: a multicenter survey[J]. CJCP, 2022, 24(9): 988-993.
