含jumonji结构域的蛋白2B和缺氧诱导因子1α在儿童非霍奇金淋巴瘤组织中的表达及意义

doi:10.7499/j.issn.1008-8830.2305025

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Abstract Objective To investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children. Methods Immunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed. Results The positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group (P<0.05). The expression of JMJD2B and HIF-1α was correlated with serum lactate dehydrogenase levels and the risk of international prognostic index in children with NHL (P<0.05). The expression of JMJD2B was positively correlated with the HIF-1α expression in children with NHL (rs=0.333, P=0.024). Conclusions JMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL.

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	Articles by authors
	DIAO Yu-Qiao
	WANG Jian
	ZHU Xiu-Li
	CHEN Jian
	ZHENG Yu
	JIANG Lian
	LIU Yue-Ping
	DAI Ruo-Heng
	YAN Yi-Wei

Key words： Non-Hodgkin's lymphoma Jumonji domain-containing protein 2B Hypoxia-inducible factor-1α Clinicopathological characteristic Prognosis Child

Received: 09 May 2023

Cite this article:

DIAO Yu-Qiao,WANG Jian,ZHU Xiu-Li et al. Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children[J]. CJCP, 2023, 25(11): 1150-1155.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2305025 OR http://www.zgddek.com/EN/Y2023/V25/I11/1150

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