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    CLINICAL RESEARCH
  • ● CLINICAL RESEARCH
    Curative effects and safety of deferasirox in treatment of iron overload in children with β-thalassemia major
    GAO Hong-Ying, LI Qi, CHEN Juan-Juan, CHEN Guang-Fu, LI Chang-Gang
    2011, 13(7): 531-534.
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    OBJECTIVE: To study the effectiveness and safety of deferasirox (DFX) in the treatment of iron overload in children with β-thalassemia major. METHODS: Twenty-four β-thalassemia major children with iron overload who received regular blood transfusion were randomly enrolled. The serum feritin (SF) levels were measured in the patients after different doses of DFX treatment. The DFX treatment-related adverse events were observed. The values of cardiac MRI T2* and liver MRI T2* were compared between the patients receiving DFX treatment for 5 years and the patients treated with deferoxamine and deferiprone. RESULTS: The patients with iron overload did not respond to DFX at the initial dose of 20-30 mg/kg?d. However, the SF level decreased significantly after the dose of DFX increased to 30-40 mg/kg?d (U=58, P<0.01). Serum liver transaminase elevation was the most common adverse effect, followed by non-progressive elevation in serum creatinine level. The mean SF level was significantly lower (1748±481 ng/mL vs 3462±1744 ng/mL; P<0.05), in contrast, the liver MRI T2* value was significantly higher (8.5±2.9 ms vs 2.7±1.9 ms; P<0.01) in patients receiving DFX treatment for 5 years than in the controls. There were no significant differences in the cardiac MRI T2* value between the two groups. CONCLUSIONS: DFX can reduce SF levels in a dose-dependent manner in children with β-thalassemia major. It can significantly lower liver iron overload but not cardiac overload. Serum liver transaminase elevation and non-progressive elevation in serum creatinine level are major adverse effects in DFX treatment.
  • ● CLINICAL RESEARCH
    Value of soluble transferrin receptor in the diagnosis of iron deficiency in children
    WANG Ya-Ping, SHAO Jie, ZHUANG Xue-Ling
    2011, 13(7): 535-538.
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    OBJECTIVE: To study the prevalence of iron deficiency in children between 6 months and 7 years and to study the diagnostic value of soluble transferrin receptor (sTfR) for iron deficiency in the children. METHODS: A total of 502 healthy children between 6 months and 7 years from Hangzhou City of Zhejiang Province were enrolled. Serum sTfR, serum ferritin (SF), serum iron (SI), total iron blinding capacity (TIBC), zinc protoporphyrin (ZPP), Hb, MCV and CRP levels were measured. RESULTS: The prevalence rate of iron deficiency was 19.5% in children at ages of 6 months to 7 years. The prevalence rate of iron deficiency was the highest in infants (≤1 year old; 34.7%), followed by in toddlers (1-3 years old; 19.4%) and preschoolers (3-7 years old; 14.0%). The mean serum sTfR level in infants (2.02±0.73 mg/L) was significantly higher than that in toddlers (1.68±0.40 mg/L) and preschoolers (1.67±0.29 mg/L) (P<0.05).The best cut-off value of serum sTfR for the diagnosis of iron deficiency was 2.02 mg/L in infants (sensitivity: 70.3%, specificity: 82.2%). The best cut-off value was 1.85 mg/L in toddlers (sensitivity: 71.7%; specificity: 86.4%), and that was 1.85 mg/L in preschoolers (sensitivity: 77.8%; specificity: 88.6%). Serum sTfR was correlated with SF (r=0.107, P<0.05), TIBC (r=0.276, P<0.01), TS (r=-0.139, P<0.05), ZPP (r=0.175, P<0.01) and MCV (r=-0.140, P<0.01). CONCLUSIONS: Iron deficiency is more prevalent in infants ≤1 year old. The mean serum level and the cut-off value of sTfR in infants are higher than in toddlers and preschoolers. Serum sTfR is an effective index for the diagnosis of iron deficiency in children, especially in infants≤ 1 year old.
  • ● CLINICAL RESEARCH
    Association of adiponectin gene polymorphism with obesity in children
    WU Jing, YAN Wei-Jian, MO Juan, YANG Hao-Bo, WANG Zhao-Zhao, LEI Min-Xiang, PENG Lie-Wu
    2011, 13(7): 539-542.
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    OBJECTIVE: To study the distribution characteristics of adiponectin gene +45 single nucleotide polymorphisms (SNP) in Chinese children, and to determine the role of adiponectin gene +45 polymorphisms in the pathogenesis of childhood obesity. METHODS: A total of 147 Chinese obese and 118 healthy children were randomly selected and enrolled to identify adiponectin gene SNP+45 polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Plasma adiponectin levels were determined using ELISA. Waist circumference (WC), waist to hip ratio (WHR), percentage of body fat (%BF), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), plasma fasting insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) were measured. RESULTS: The allelic frequency of adiponectin gene SNP+45 in children with obesity and healthy controls were 40.5% and 25.4%, respectively. There were significant differences in the distribution of genotypes and the allelic frequency between the two groups (P<0.05). The plasma adiponectin levels were significantly higher, in contrast, %BF, HOMA-IR, TC and LDL-C levels were significantly lower in obese children with TT genotype than those in obese children with TG or GG genotype. CONCLUSIONS: The adiponectin gene SNP+45 polymorphism may be associated with pathogenesis of obesity in children. T→G variance may be associated an increased risk of childhood obesity and result in a decreased level of adiponectin.
  • ● CLINICAL RESEARCH
    Prognosis and its affecting factors in children with acute respiratory distress syndrome
    NIU Zhi-Min, LI Yan-Hong, JIANG Shun-Jie, MAO Xiang-Ying, LI Yu-Jie
    2011, 13(7): 543-546.
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    OBJECTIVE: To study the prognosis and the factors affecting the prognosis in children with acute respiratory distress syndrome (ARDS). METHODS: Seventy-eight children with ARDS were enrolled. The states of their survival within 30 days were followed-up. RESULTS: Of the 78 children with ARDS, 51 cases demised, 27 cases survived, with a 30-days survival rate of 35%. The average survival time was 14.4 days (median: 8 days). The peak of death appeared within 3 days after ARDS. There were significant differences in aspects of age, primary disease, percentage of neonatal hyaline membrane disease, pediatric critical illness score (PCIS), duration of mechanical ventilation, oxygenation index (PaO2/FiO2), white blood cell count and number of involved organs between the died and survived children (P<0.05 or 0.01). The Cox multiple factors analysis showed that the age (HR 3.924~3.938), primary disease (HR=1.817) and PCIS (HR=0.469) were the risk factors of death. CONCLUSIONS: The peak of death usually appears within 3 days after ARDS. Age, primary disease and PCIS are the independent factors of prognosis in children with ARDS.
  • ● CLINICAL RESEARCH
    Role of flexible bronchoscopy in the diagnosis and treatment of refractory pneumonia in children
    AN Shu-Hua, WANG Meng-Meng, LI Jin-Ying, ZHENG Bo-Juan, WANG Yan-Yan, ZHAO Qing-Juan, WANG Ning
    2011, 13(7): 547-550.
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    OBJECTIVE: To evaluate the effectiveness of the flexible bronchoscopy in the diagnosis and treatment of refractory pneumonia among children. METHODS: Sixty children with refractory pneumonia were randomly divided into two groups: lavage and control (n=30 each). The control group received conventional medical treatment. The lavage group was given flexible bronchoscopy besides conventional medical treatment. The therapeutic effects were compared between the two groups. The results of bacterial culture and detection of antibodies against Mycoplasma pneumoniae in bronchoalveolar lavage fluid (BALF) were observed. RESULTS: The coincidence of bacterial culture results between BALF and sputum samples was 63.3%, and there were no significant differences in the positive bacterial culture results between them. The coincidence of PCR test for antibodies against Mycoplasma pneumoniae between BALF and serum samples was 73.3%. The results of Fisher's exact test showed the positive rate of Mycoplasma pneumoniae antibodies of BALF was higher than that of serum (P<0.05). The effective rate in the lavage group was significantly higher than that in the control group (97% vs 73%; P<0.01). CONCLUSIONS: The flexible bronchoscopy is useful for the diagnosis and treatment of refractory pneumonia in children.
  • ● CLINICAL RESEARCH
    Serum levels of 25-(OH)D3 and total IgE in children with asthma
    MA Xiu-Li, ZHEN Yan-Fen
    2011, 13(7): 551-553.
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    OBJECTIVE: To study the changes and clinical significance of serum levels of 25-(OH)D3 and total IgE in children with asthma. METHODS: Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-(OH)D3 and total IgE. RESULTS: Serum 25-(OH)D3 levels (18±3 ng/Ml)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43±3 ng/mL) and the control group (43±3 ng/mL) (P＜0.01). In contrast, serum total IgE levels (192±16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (123±14 IU/mL) and the control group (118±15 IU/mL) (P<0.01). Serum 25-(OH)D3 levels were negatively correlated with serum total IgE levels in asthmatic children (r=-0.783, P<0.01). There were no correlation between serum 25-(OH)D3 levels and serum total IgE level in the asthmatic bronchitis and the control groups. CONCLUSIONS: 25-(OH)D3 may play an important role in the pathogenesis of asthma. The increased serum 25-(OH)D3 level may inhibit total IgE expression, suggesting that increasing serum 25-(OH)D3 level might be a new option for the prevention and treatment of asthma.
  • ● CLINICAL RESEARCH
    Roles of allergen testing in vitro and impulse oscillometry for lung function measurements in children with cough variant asthma
    YU Zhi-Wei, XIE Juan-Juan, QIAN Jun, PAN Jian-Rong, ZHANG Xiao-Juan, XIANG Hong-Xia
    2011, 13(7): 554-557.
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    OBJECTIVE: To study the roles of allergen testing in vitro and impulse oscillometry for lung function measurements in preschool children with cough variant asthma (CVA). METHODS: ethodsForty-four preschool children with acute asthma, 41 with chronic asthma, 46 with CVA, and 35 healthy preschool children as control were recruited in the study. Inhaled allergen, food allergen, and mite-specific IgE were determined by Pharmacia UniCAP System. Serum eosinophil cationic protein (ECP) and total IgE levels were measured. Lung function was assessed by impulse oscillometry. RESULTS: The positive rates of inhaled allergen and food allergen, and total IgE levels in the CVA, acute asthma and chronic asthma groups were higher than those in the control group (P<0.01). However, no significant differences were found among the three case groups. The serum ECP levels in the CVA group were lower than those in the acute asthma group (P<0.01), but did not show differences when compared with the chronic asthma group. The impulse oscillometry demonstrated that the respiratory total impedance (Zrs), airway resistance at 5 Hz (R5), airway resistance at 20 Hz (R20), subtracting R5 from R20 (R5-R20) and resonant frequency (Fres) in the CVA, acute asthma and chronic asthma groups were higher than those in the control group (P<0.01). Zrs, R5, R20, R5-R20, and Fres in the CVA and chronic asthma groups were lower than those in the acute asthma group (P<0.01). Serum ECP levels were positively correlated with Zrs, R5, R5-R20 and Fres (P<0.05) in the CVA and chronic asthma groups. CONCLUSIONS: The measurements of allergens, serum ECP and impulse oscillometry for lung function are helpful for the evaluation of airway inflammation and airway obstruction in preschool children with CVA.
  • ● CLINICAL RESEARCH
    Clinical efficiency of transcatheter occlusion of large patent ductus arteriosus in children
    Abulaiti ABDUHAER, RU Liang, Amanguli TIEMUER, YANG Jie
    2011, 13(7): 558-560.
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    OBJECTIVE: To study the clinical efficiency of transcatheter closure of large patent ductus arteriosus (PDA) using Amplatzer ductal occluder in children. METHODS: A retrospective review was performed for 227 children with large PDA, including 63 cases with pulmonary artery hypertension. All cases accepted the transcatheter closure using Amplatzer ductal occluders. The median age of the patients was 3.2 years, and the median weight was 10.6 kg. The median of the narrowest diameter of arterial ducts was 5.7 mm. RESULTS: Successful occlusion was achieved in 216 (95.2%) of the 227 cases. The mean pulmonary artery pressure in children with pulmonary artery hypertension decreased from 45±19 mm Hg before operation to 22±12 mm Hg after operation (P<0.05). In the 216 children achieving a successful occlusion, 109 children (50.5%) showed a complete occlusion immediately after operation by aortography and 181 children (83.8%) showed a complete occlusion by echocardiography 24 hrs after operation. No residual shunt was found in children who achieved a successful occlusion according to the results of echocardiography 6 and 12 months after operation. CONCLUSIONS: The transcatheter occlusion of large PDA using Amplatzer ductal occluders is effective and safe in children.
  • ● CLINICAL RESEARCH
    The under-five mortality rate and the causes of death in Zhejiang Province between 2000 and 2009
    XU Yan-Hua, HUANG Xin-Wen, YANG Ru-Lai
    2011, 13(7): 561-564.
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    OBJECTIVE: To study the underfive mortality rate and the causes of death in Zhejiang Province between 2000 and 2009 in order to provide a basis for reducing the mortality rate in the region. METHODS: By stratified random cluster sampling, all the children under 5 years old from 30 sampling areas of Zhejiang Province between 2000 and 2009 were enrolled. The under-five mortality rate and the leading causes of death were investigated by descriptive analysis and Chi-square test. RESULTS: The under-five mortality rate demonstrated a decreased trend in Zhejiang Province between 2000 and 2009, with the under-five mortality rate of 14.83‰ in 2000 compared to 9.49‰ in 2009. In 2009, the under-five mortality rate in rural regions was significantly higher than that in urban regions (9.14‰ vs 6.50‰; P<0.01). Compared with the resident population, there were an increased under-five mortality rate in floating population (12.12‰ vs 6.42‰; P<0.01). Preterm delivery/low birth weight was the top death cause in children under 5 years old. The top three causes of death in infants less than 1 year old were preterm delivery/low birth weight, congenital heart disease and birth asphyxia compared to drowning, traffic accident and falling in children aged 1-4 years. CONCLUSIONS: There are differences in the under-five mortality rate between rural and urban children as well as between the floating and resident population in 2009. The leading causes of death in different age groups are different. It is essential to reduce the mortality rate by preventing preterm delivery, low birth weight and congenital malformations to infants and preventing accidental injuries to children aged 1-4 years.
  • ● CLINICAL RESEARCH
    Investigation of sleep patterns and sleep disorders in Uigur and Hui children in Xinjiang
    Tajiguli ABUZHARE, XU Pei-Ru, Amanguli TIEMUERA, ZHANG Ji-Hong
    2011, 13(7): 565-568.
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    OBJECTIVE: To study the sleep quality and quantity and their influencing factors in Uigur and Hui children in Xinjiang Province. METHODS: From March to December of 2007, 912 Uigur and 1019 Hui school children (6 to 14 years) were randomly sampled from 6 cities of Xinjing Province. The questionnaire on children′s sleep states and sleep environments was filled in by children′s parents. RESULTS: The mean sleep time of Uigur and Hui children was 10.1±1.4 hrs. The sleep time in Uigur children was significantly less than that in Hui children (9.7±1.2 hrs vs 10.4±1.5 hrs; P<0.05). The mean incidence of sleep disorders was 23.56%. The Uigur children had a lower incidence of sleep disorders compared with the Hui children (18.42% vs 28.16%; P<0.001). Ethnic group, sleep latency, use of a swing bed, family history of snore, watching TV before sleeping, hypertrophy of tonsils, eating before sleeping, feeding patterns and recurrent upper respiratory tract infection were the factors associated with the sleep quality and quantity. CONCLUSIONS: The influencing factors of sleep quality and quantity are multifactorial in Uigur and Hui children in Xinjiang Province. Pediatrician, child health care doctors and parents should pay more attention to children's sleep. The incidence of sleep disorders is different between Uigur and Hui children, suggesting that more research for the prevention and treatment of sleep disorders should be performed in different ethic groups.
    • COMPLICATED CASE STUDY
  • ● COMPLICATED CASE STUDY
    Leigh syndrome due to mitochondrial respiratory chain complex II deficiency
    MA Yan-Yan, WU Tong-Fei, LIU Yu-Peng, WANG Jiao, SONG Jin-Qing, XIAO Jiang-Xi, JIANG Yu-Wu, YANG Yan-Ling
    2011, 13(7): 569-572.
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    Mitochondrial respiratory chain complex II deficiency is a rare documented cause of mitochondrial diseases. This study reported a case of Leigh syndrome due to isolated complex II deficiency. A boy presented with progressive weakness, motor regression and dysphagia after fever from the age of 8 months and hospitalized at the age of 10 months. Elevated blood levels of lactate and pyruvate were observed. Brain magnetic resonance image showed symmetrical lesions in the basal ganglia. Mitochondrial respiratory chain complex I-V activities in peripheral leukocytes were measured using spectrophotometric assay. Mitochondrial gene screening of common point mutations was performed. The complex II activity in the peripheral leukocytes decreased to 21.9 nmol/min per mg mitochondrial protein (control: 47.3±5.3 nmol/min per mg mitochondrial protein). The ratio of complex II activity to citrate synthase activity (22.1%) also decreased (control: 50.9%±10.7 %). No point mutation was found in mitochondrial DNA. The boy was diagnosed as Leigh syndrome due to isolated complex II deficiency. Psychomotor improvements were observed after the treatment. The patient is 22 months old and in a stable condition.
    • EXPERIMENTAL RESEARCH
  • ● EXPERIMENTAL RESEARCH
    Effects of maternal deficiency of folic acid during pregnancy on pulmonary development and SP-A expression in newborn rats
    QIAO Li-Xing, YU Zhang-Bin, HAN Shu-Ping, GU Xiao-Qi, CHEN Yu-Lin, SHA Li, JIN Jun-Xia, YAN Lu-Biao, GUO Xi-Rong
    2011, 13(7): 573-576.
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    OBJECTIVE: This study examined the effects of maternal deficiency of folic acid during pregnancy on pulmonary development and protein A (SP-A) expression in newborn rats in order to explore the possible mechanism of lung developmental disorders. METHODS: Thirty-six adult Sprague-Dawley female rats were randomly assigned into two groups: control and study (n=18). The study and the control groups were fed with fodder containing folic acid or not respectively. Two weeks later, the female rats in the two groups copulated with normal male rats. Newborn rats were sacrificed at 1, 7 and 14 days after birth (8 pups at each time point). Lung sections were stained with hematoxylin and eosin for histological examination. SP-A expression of protein and mRNA were determined by immunohistochemistry and real-time quantitative RT-PCR, respectively. RESULTS: The newborn rats from the study group showed damaged lung tissue structures. The mean optical density of type II cells with positive expression of SP-A decreased significantly from 1 to 14 days in newborn rats of the study group compared with the control newborn rats (P<0.05). The real-time quantitative RT-PCR showed that the expression of lung SP-A mRNA also decreased significantly from 1 to 14 days in newborn rats of the study group compared with control newborn rats (P<0.05). CONCLUSIONS: Maternal deficiency of folic acid during pregnancy can decrease the expression of SP-A in lung tissues of newborn rats, which might lead to the disorder of lung development maturation.
  • ● EXPERIMENTAL RESEARCH
    Expression of heme oxygenase-1 and inducible nitric oxide synthase in the lungs of hyperoxia-exposed preterm rats
    QUAN Yu-Feng, ZHENG Ming-Ci, ZHANG Hua, ZHANG Pei-Lin, ZHANG Hong
    2011, 13(7): 577-580.
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    OBJECTIVE: To study the expression and the role of heme oxygenase-1 (HO-1) and inducible nitric oxide synthase (iNOS) in preterm rats with hyperoxia-induced lung injuries. METHODS: Sixty-four three-day-old preterm Sprague-Dawley rats were randomly assigned to a hyperoxia group (90% oxygen exposure) and a control group (room air exposure), with 32 rats in each group. After 3 days or 7 days of exposure, the lung activity of HO-1 and nitric oxide (NO) contents in bronchoalveolar lavage fluid (BALF), pulmonary histopathologic changes, and the cellular distribution and expression of HO-1 and iNOS in the lungs were measured. RESULTS: After 3 days and 7 days of exposure, the hyperoxia group showed acute lung injuries characterized by the presence of hyperaemia, red cell extravasation and inflammatory infiltration. The NO contents in BALF and the iNOS expression in the lungs increased significantly in the hyperoxia group compared with those in the control group 3 and 7 days after exposure. The expression of HO-1 in macrophages in the lungs increased significantly in the hyperoxia group compared with that in the control group 3 and 7 days after exposure. The NO contents in BALF and the iNOS and HO-1 expression in the lungs increased significantly 7 days after hyperoxia exposure compared with 3 days after hyperoxia exposure. CONCLUSIONS: iNOS and HO-1 levels in the lungs increase in preterm rats with hyperoxia-induced lung injuries, suggesting that iNOS and HO-1 may play roles in hyperoxia-induced pulmonary injuries.
  • ● EXPERIMENTAL RESEARCH
    Expression of ERK1/2 protein in lung tissues of newborn rats with hyperoxia-induced chronic lung disease
    HU Yu, LIU Xue-Yan, FU Jian-Hua, XUE Xin-Dong
    2011, 13(7): 581-585.
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    OBJECTIVE: To study the expression of extracellular signal regulated protein kinase (ERK) 1/2 in lung tissues of newborn rats with chronic lung disease (CLD) caused by hyperoxia. METHODS: Forty-eight full-term newborn rats were randomly divided into two groups: hyperoxia and control. The two groups were exposed to a hyperoxic gas mixture (0.90 O2) for an induction of CLD and room air within 12 hrs after birth, respectively. The levels of ERK1/2 protein and mRNA in lung tissues were measured using immunohistochemistry, Western blot and real-time PCR methods on postnatal days 3, 7 and 14. The severity of pulmonary fibrosis was evaluated. RESULTS: The expression of p-ERK protein in lung tissues in the hyperoxia group was significantly higher than that in the control group on postnatal days 7 and 14 (P<0.01). There were no significant differences in the levels of total ERK1/2 protein and ERK1/2 mRNA. CONCLUSIONS: The activation of phosphorated ERK1/2 may lead to lung fibrosis caused by hyperoxia in newborn rats.
  • ● EXPERIMENTAL RESEARCH
    Effects of early enriched environment on long-term behavior development and serum corticosterone level in rats
    MA Liang, CHEN Yan-Hui, WEI Li-Xin
    2011, 13(7): 586-589.
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    OBJECTIVE: To study the effects of early enriched environment on behavioral development and serum corticosterone level in rats. METHODS: Forty-five neonatal rats were randomly assigned into three groups：blank control, enriched environment and isolated environment. The open-field environment test and the Lat maze test were performed to assess anxiety/irritability-related behaviors of the rats on postnatal day 31. The level of serum corticosterone was measured by radioimmunology assay. RESULTS: The level of serum corticosterone in the enriched environment group (8±3 ng/mL) was significantly lower than the blank control (11±4 ng/mL) and the isolated groups (22±4 ng/mL) (P<0.01). The open-field environment test showed that the numbers of passing panels, keeping an erect posture and grooming were less than those in the blank control and the isolated groups (P<0.05). According to the results of the Lat maze test, the frequencies of running across the corner, keeping an erect posture and leaning against the wall in the enriched environment group were less than those in the blank control and the isolated groups (P<0.05). CONCLUSIONS: Early enriched environment can decrease serum corticosterone level and thus alleviates anxiety and irritability in rats. It may play an important role in the improvement of brain development.
    • CLINICAL EXPERIENCE
  • ● CLINICAL EXPERIENCE
    Application of radio frequency current ablation in 180 children with paroxysmal supraventricular tachycardia
    ZHAO Peng-Jun, MA Li, WANG Xi-Ke, LI Jun, YANG Jian-Ping, LI Fen
    2011, 13(7): 590-592.
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    No abstract available
  • ● CLINICAL EXPERIENCE
    Clinical analysis of 45 cases of childhood Ⅲ°atrial ventricular block
    DONG Hai-Yun, LIU Dong-Hai, LV You-Ti , TANG Jian-Jun
    2011, 13(7): 593-594.
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    No abstract available
  • ● CLINICAL EXPERIENCE
    Influence of different kinds of infusion solutions during renal transplantation on blood glucose levels in children
    DAI Min-Hui, YAN Kun, LU Can
    2011, 13(7): 595-597.
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    No abstract available
    • CASE REPORT
  • ● CASE REPORT
    Slipped capital femoral epiphysis in two infant with epilepsy
    GUO Yue-Chao, WANG En-Bo, ZHAO Qun
    2011, 13(7): 598-599.
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    No abstract available
  • ● CASE REPORT
    Blueberry muffin in 2 neonates
    WU Hui, WANG Guo-Hua, YAN Chao-Ying
    2011, 13(7): 600-601.
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    No abstract available
  • ● CASE REPORT
    A case report of Bardet-Biedl syndrome
    ZHENG Xiang-Rong, YIN Fei, HUANG Rong, XIANG Qiu-Lian
    2011, 13(7): 602-603.
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    No abstract available
  • ● CASE REPORT
    A case report of Apert syndrome
    LI Hong-Hua, HAO Yun-Peng, DU Lin, JIA Fei-Yong
    2011, 13(7): 604-605.
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    No abstract available
    • REVIEW
  • ● REVIEW
    Research progress in the mechanism of brain self-repair
    LI Wen-Juan, CHEN Hui-Jin
    2011, 13(7): 606-611.
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    No abstract available