CJCP
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2012 Vol.  14 No.  06
Published: 2012-06-15
CLINICAL RESEARCH
CLINICAL EXPERIENCE
CASE REPORT
REVIEW
CLINICAL RESEARCH
401 DUAN Jiang, HE Xi-Yu, ZHENG Tian, KONG Xiang-Yong, FENG Zhi-Chun
Clinical application of proportional assist ventilation in very low birth weight infants with ventilator dependence
OBJECTIVE: To study the effect of proportional assist ventilation (PAV) on physiology and respiratory mechanics in very low birth weight (VLBW) infants with ventilator dependence by comparison with conventional assist/control (A/C) ventilation. METHODS: Forty-six infants with ventilator dependence were randomly divided into two groups according to the ventilation model: PAV (n=23) and A/C (n=23). The gain of resistive and elastic unloading was set based on the runway method in the PAV group. Ventilation parameters were set based on the conventional method in the A/C group. Infants were observed for 30 minutes three times per day for three consecutive days. Arterial gas analysis results, transcutaneous saturation of oxygen (SPO2), heart rate, blood pressure (BP), respiratory rate (RR), mean airway pressure (MAP), peak inspiratory pressure (PIP), tide volume (VT), minute volume (MV) and oxygenation index (OI), were compared between the two groups. RESULTS: Compared with the A/C group, PaO2 and OI in the PAV group were significantly higher while PIP and MAP were significantly lower. There were no significant differences in FiO2, SPO2, pH, PaCO2, PEEP, VT, MV and RR between the two groups. Although mean arterial blood pressure and heart rate in the PAV group were not different from the A/C group, beat-to-beat variabilities in systolic and diastolic arterial blood pressure were significantly lower in the PAV group than in the A/C group. CONCLUSIONS: PAV may safely maintain gas exchange at lower airway pressures compared with A/C ventilation in VLBW infants. It can also improve oxygenation and infant-ventilator synchronization.
2012 Vol. 14 (06): 401-405 [Abstract] ( 4638 ) [HTML 1KB] [PDF 999KB] ( 1325 )
406 LI Xue-Chao, WANG Jian-Zhong, LIU Yuan-Hui
Effect of probiotics on respiratory tract pathogen colonization in neonates undergoing mechanical ventilation
OBJECTIVE: To study the effect of mouth-fed probiotics on pathogenic bacteria colonization of the oropharynx and lower respiratory tract in neonates undergoing mechanical ventilation. METHODS: Randomized control method was employed to divide the neonates undergoing mechanical ventilation into probiotics (n=82) and control groups (n=83). The control group received routine treatment. The probiotics group was administered with oral probiotics in addition to routine treatment. The number of pathogenic bacteria colonized on the oropharynx and lower respiratory tract, and the number of the bacterial strain of ventilator-associated pneumonia (VAP) in the two groups were examined. The timing of the bacteria colonization and VAP occurrence were also examined. RESULTS: The probiotics group presented a lower bacterial strain colonization rate of the oropharynx pathogenic bacteria than the control group (35% vs 51%; P<0.05). The colonization time of pathogenic bacteria of the oropharynx and lower respiratory tract, and the time of VAP occurrence lagged behind in the probiotics group compared with that the control group (P<0.05). No adverse reaction caused by probiotics was found. CONCLUSIONS: Probiotics administration is effective in decreasing pathogenic bacteria colonization on the oropharynx, in postponing the pathogenic bacteria colonization on the oropharynx and lower respiratory tract and in delaying the occurrence of VAP in neonates undergoing mechanical ventilation.
2012 Vol. 14 (06): 406-408 [Abstract] ( 5688 ) [HTML 1KB] [PDF 902KB] ( 1874 )
418 LU Yan-Hong, LIU Xiao-Ying, SONG Yuan
Effects of early treatment on physical and intelligence development in children with congenital hypothyroidism
OBJECTIVE: To compare differences in the intelligence and physical developmental levels of children with congenital hypothyroidism (CH) who received initial treatment at different times. METHODS: Forty-nine children with CH diagnosed by neonatal screening between September 2008 and September 2011 were enrolled in this study. According to the timing of initial treatment with thyroid hormone, they were classified into two groups: 0.05) at 6 months old, 1 year and 2 years old. However, heights and weights in the 0.05). CONCLUSIONS: The timing of initial treatment with thyroid hormone appears to be associated with the intelligence and physical development in children with CH. Treatment starting at less than 1 month of life contributes to improved physical and intelligence development compared with treatment starting at 1 to 3 months of life.
2012 Vol. 14 (06): 418-421 [Abstract] ( 4847 ) [HTML 1KB] [PDF 914KB] ( 1296 )
422 JIANG Rong, ZHAO Sheng, LI Mei, LIU Feng, LI Lin, YANG Gui-Ming, WANG Ze-Long, YU Dong, HUANG Li-Hua, HUANG Xiao-Bi
Myocardial injury and inflammatory response after interventional therapy in children with congenital heart disease
OBJECTIVE: To study myocardial injury and inflammatory response within 7 days after interventional therapy in children with congenital heart disease (CHD). METHODS: A total of 77 children with CHD, including 12 cases of ventricular septal defect (VSD), 14 cases of atrial septal defect (ASD), 14 cases of pulmonary stenosis (PS) and 37 cases of patent ductus arteriosus (PDA), were enrolled. The levels of myocardial enzyme (AST, CK and CKMB), cardiac troponin I (cTnI) and CRP in serum were measured before operation, immediately after operation, and 6 hrs, 24 hrs, 72 hrs and 7 days after operation. RESULTS: Serum AST levels in the VSD group were significantly higher than the other CHD groups immediately after operation, and 6 hrs and 24 hrs after operation (P<0.05). There were significant differences in serum CK and CKMB levels among the four CHD groups immediately and 6 hrs after operation (P<0.05), and the highest serum CK and CKMB levels were found in the VSD group. Serum CRP levels in the PDA group were significantly higher than the other CHD groups 72 hrs and 7 days after operation (P<0.05). Compared with before operation, serum AST levels increased significantly in all four CHD groups 6 and 24 hrs after operation groups (P<0.05). Serum CK and CKMB levels increased significantly in the VSD group immediately and 6 hrs after operation (P<0.05). Serum cTnI levels increased significantly in the VSD, PDA and PS groups immediately and 6 hrs after operation (P<0.05). The PDA group showed increased CRP levels 24 hrs, 72 hrs and 7 days after operation (P<0.05). CONCLUSIONS: Minor myocardial injury can be noted within 7 days after interventional therapy in children with CHD and mainly occurs between immediately and 24 hrs after operation. The injury is more significant in VSD cases. The interventional therapy does not cause significant inflammation.
2012 Vol. 14 (06): 422-425 [Abstract] ( 5071 ) [HTML 1KB] [PDF 914KB] ( 1087 )
426 ZHANG Hai-Yan, LIU Chang-Yun, WANG Yong-Qin
Risk factors for Tourette syndrome
OBJECTIVE: To identify the risk factors for Tourette syndrome (TS) in children. METHODS: Through a genetic epidemiologic case control study, segregation ratio was estimated using the method of Li-Manted-Gart in 80 children with TS. Heritability for the first- and second-degree relatives was estimated using the Falconer regression method. In addition, the 80 children and 80 controls with other diseases were evaluated using the Family Environment Scale and a self-designed questionnaire. Risk factors for TS were investigated using single factor and multifactor regression analysis. RESULTS: The segregation ratio of TS was 0.1176. Heritabilities for the first- and second-degree relatives were (49.7±2.6)% and (21.5±3.4) % respectively. The weighted mean heritability of the first-degree and second-degree relatives was (39.5±2.1)%. Significantly decreased scores were noted in independence, active-recreational orientation and organization and increased scores were noted in the conflict and control in the TS group compared with the control group (P<0.01). Single factor analysis indicated that the risk factors for TS included family history, type of home education, maternal smoking, family conflict, low level of parental education, family control and fetal anoxia. Multifactor regression analysis indicated that there were five important risk factors for TS: family history, family conflict, type of family education, low level of parental education and maternal smoking. CONCLUSIONS: Both heredity and environment are involved in the pathogenesis of TS. The mode of inheritance for TS is polygenic. Improving the living environments of children with a family history of TS is of prime importance.
2012 Vol. 14 (06): 426-430 [Abstract] ( 5580 ) [HTML 1KB] [PDF 928KB] ( 1164 )
431 ZHANG Tao, LIAO Jia-Yi
Serum levels of human β-defensins 1 and immunoglobulins A, G and M in infants with recurrent pneumonia
OBJECTIVE: To study the possible role of human β-defensins 1 (Hbd-1) and immunoglobulins A, G and M (IgA, IgG and IgM) in the development of recurrent pneumonia by measuring serum concentrations of the above indexes in infants with recurrent pneumonia and healthy infants. METHODS: Serum samples were obtained from 35 healthy children and 35 children aged from 2 to 24 months with recurrent pneumonia. Serum Hbd-1 concentration was measured using ELISA. Serum IgA, IgG and IgM concentrations were measured by immunonephelometry. The correlation of hBD-1 with IgA, IgG and IgM was evaluated. RESULTS: The serum concentration of hBD-1 in infants with recurrent pneumonia (14±11 μg/mL) was significantly lower than in controls (18±11 μg/mL) (P0.05). CONCLUSIONS: The serum levels of hBD-1, IgA and IgG decrease in infants with recurrent pneumonia, suggesting disorders in the immune defensive function of the respiratory tract, and this may be one of the immunity related reasons for recurrent pneumonia in infants. It is of great clinical value to measure serum levels of Hbd-1, IgA, IgG and IgM in infants with recurrent pneumonia.
2012 Vol. 14 (06): 431-433 [Abstract] ( 3800 ) [HTML 1KB] [PDF 905KB] ( 1128 )
434 ZHENG Wei-Hua, LI Xiong, YANG Fang-Yuan, WANG Xin, PENG Juan, OU Wei-Lin
Chest X-ray findings in children with enterovirus 71 infection
OBJECTIVE: To study the characteristics of the chest X-ray images in children infected with enterovirus 71. MethodsA total of 120 children with enterovirus 71 infection between April, 2010 and July, 2011 were classified into three groups according to the disease condition: mild (31 cases), severe (43 cases) and life-threatening (46 cases). The period from the onset of clinical symptoms to the first chest X-ray imaging examination and the results of the first chest X-ray findings were compared among the three groups. RESULTS: The period from the onset of clinical symptoms to the first chest X-ray imaging examination in the mild, severe and life-threatening groups was 26- 48 hrs (median 37 hrs), 10-36 h (median 23 hrs) and 2-36 hrs (median 19 hrs) respectively. Chest X-ray abnormalities were initially observed at 30 hrs after the onset of clinical symptoms in the mild group, at 23 hrs in the severe group and at 2 hrs in the life-threatening group (P<0.01). The mild group presented an initial imaging abnormality rate of 5.8%, the severe group 81.3% and the life-threatening group 100%. The life-threatening group showed a significantly higher initial X-ray abnormality rate than the other two groups (P<0.01). In terms of chest X-ray performance, the mild group usually presented lung marking thickening or vagueness. Most children in the severe group presented lung effusion and consolidation. Signs of pulmonary edema were found in the life-threatening group, and lesions in the life-threatening group were characterized by wide distribution and many lung lobe involvements. CONCLUSIONS: The interval between the onset of clinical symptoms and the initial chest X-ray examination, the period of time of, and the onset of clinical symptoms, at which chest X-ray abnormalities, the abnormality rate and the severity of chest X-ray findings may be paralleled to the clinical situation in children with enterovirus 71 infection.
2012 Vol. 14 (06): 434-436 [Abstract] ( 4117 ) [HTML 1KB] [PDF 978KB] ( 1039 )
437 ZHANG Yi, GUO Fang, ZHANG Wei-Ling, HUANG Dong-Sheng, HONG Liang, HAN Tao
Clinical application of 125I particle implantation in children with rhabdomysarcoma of the head and neck
OBJECTIVE: To study the efficacy and safety of 125I particle implantation in the treatment of rhabdomysarcoma (RMS) of the head and neck in children. METHODS: Eight children (four males and four females) with RMS of the head and neck received 125I particle implantation targeted to the primary lesion area. The primary lesions were noted in eyelids or eyes in two children, in the orbit in four children, and in the nasal cavity or nasal wing in two children. Treatment outcomes and side effects were observed. RESULTS: The follow-up visits averaged 45±17 months (median 43 months) in the eight children receiving 125I particle implantation. Five children achieved a complete remission, 2 children achieved a complete remission and 1 child died. The total survival rate was 88% in the 8 children. Local pigmentation was observed in all eight children (100%). Nubecula (one case), eyeball pain (one case), serious blurred vision (one case), cornea ulcer and blindness (one case) and bleeding of the nasal cavity (one case) were also observed. Except for nubecula and blindness, these side effects were improved by symptomatic treatment. CONCLUSIONS: 125I particle implantation appears to be effective in the treatment of RMS of the head and neck in children. Most treatment-related side effects can be improved by symptomatic treatment.
2012 Vol. 14 (06): 437-440 [Abstract] ( 4017 ) [HTML 1KB] [PDF 1016KB] ( 1059 )
441 WANG Zu-Fang, LI Gui-Jun
Value evaluation of follicle stimulating hormone and luteinizing hormone in the diagnosis of precocious puberty in girls by ROC curve analysis
OBJECTIVE: To study the value of follicle stimulating hormone (FSH), luteinizing hormone (LH) and LH/FSH ratio in the diagnosis of precocious puberty in girls by ROC curve analysis. METHODS: Gonadotropin-releasing hormone (GnRH) stimulation test was performed on 220 girls with pseudo-sexual precocity and 61 girls with true sexual precocity. Blood LH and FSH levels were measured before and after 30 and 60 minutes of taking the GnRH test. The ratio of LH to FSH was calculated. Sensitivity and best point for the diagnosis of precocity according to LH, FSH and LH/FSH ratio were analyzed by ROC curve analysis. RESULTS: The area under the ROC curve was 0.90 and 0.95 according to LH level and LH/FSH ratio respectively for the diagnosis of precocity. The best point for diagnosis by LH was 10.15 IU/L, with a sensitivity of 0.92 and specificity of 0.89. The best point for diagnosis by LH/FSH ratio was 0.60, with a missed diagnosis rate of 6.0% and specificity of 0.91. When true sexual precocity was diagnosed based on one index between LH>10.15 IU/L and LH/FSH ratio>0.60, sensitivity was 0.97 and specificity was 0.94. When the diagnosis of true sexual precocity was diagnosed based on both LH>10.15 IU/L and LH/FSH>0.60, sensitivity was 0.85 and specificity was 1.00. CONCLUSIONS: True sexual precocity can be diagnosed when both LH>10.15 IU/L and LH/FSH ratio>0.60. Only one of the two indexes for the diagnosis of true sexual precocity is presented, further observation is necessary to decrease missed diagnosis and misdiagnosis.
2012 Vol. 14 (06): 441-444 [Abstract] ( 4945 ) [HTML 1KB] [PDF 1393KB] ( 1329 )
445 ZHAN Shi-Na, WANG Chun-Zhi, YANG Yao, WANG Yan, WU Hong-Lin, LI Hao, HE Xi-Yu
Value of methylation-specific mutiplex ligation-dependent probe in the diagnosis of Prader-Willi syndrome
OBJECTIVE: Prader-Willi syndrome (PWS) with different pathogenesis has different clinical manifestations, prognosis and genetic risks. Pathogenesis of the disease cannot be explained by conventional diagnostic method MS-PCR. This study employed methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) for the diagnosis of PWS in order to explore the role of this method in the diagnosis and assessment of pathogenesis of PWS. METHODS: A system antithetical method was employed. Peripheral blood samples were collected from 30 children for MS-PCR. Of the 30 children, 16 were diagnosed with PWS by MS-PCR and the other 14 showed negative MS-PCR. MS-MLPA kit Me028 was used to detect DNA extracted from the 30 samples. RESULTS: The results showed by MS-MLPA and MS-PCR were identical. MS-MLPA demonstrated that 4 cases were maternal uniparental disomy and 12 cases were paternal dfeletion in 15q11-q13 region. CONCLUSIONS: MS-MLPA is a reliable method of genetic testing for PWS which can distinguish pathogenesis of PWS.
2012 Vol. 14 (06): 445-448 [Abstract] ( 6295 ) [HTML 1KB] [PDF 1950KB] ( 1545 )
449 DING Xiao-Fang, ZHANG Bing, ZHONG Li-Li, XIAO Ni-Guang, ZHOU Qiong-Hua, DUAN Zhao-Jun, XIE Zhi-Ping, GAO Han-Chun
Viral etiology and risk factors for severe community-acquired pneumonia in children
OBJECTIVE: To study the virus spectrum of severe community-acquired pneumonia (CAP) and risk factors for the disease in children. METHODS: Respiratory secretion specimens were collected from 1096 children hospitalized with CAP from June 2007 to November 2008, including 100 cases of severe CAP. Respiratory viruses were detected by PCR, nest-PCR or RT-PCR. Clinical data on the children were analyzed by univariate and multivariate logistic regression analysis for examining risk factors for severe CAP. RESULTS: Viral pathogens were isolated from 82 (82%) of the 100 cases with severe CAP. RSV was the most common (37%), followed by HBoV (25%) and HRV (18%). Mixed infection was noted in 32 cases (32%). The presence of underlying diseases (OR=6.623, P<0.01) and RSV infection (OR=1.672, P<0.05) were risk factors for severe CAP in children, while age was a protective factor (OR=0.475, P<0.01). CONCLUSIONS: RSV is the most frequent viral pathogen in children with severe CAP. The presence of underlying diseases and RSV infection may be risk factors for severe CAP, while age is a protective factor.
2012 Vol. 14 (06): 449-453 [Abstract] ( 5423 ) [HTML 1KB] [PDF 930KB] ( 1459 )
409 SUN Jie, HU Xiang-Ying, ZHONG Ling, HUANG Hui
Growth follow-up of infants born macrosomia at their life of 0 to 18 months
OBJECTIVE: To study the growth of macrosomic infants, the incidence of overweight and the factors related to overweight at 18 months old. METHODS: Eighty-four macrosomic infants without underlying diseases were enrolled in this study. Their growth was followed up regularly. Factors related to overweight at 18 months old were investigated. RESULTS: Twenty infants (24%) showed as overweight at 18 months old. More male infants were overweight than female infants (30% vs 11%; P<0.05). The overweight infants at 18 months old had a higher proportion of overweight at 6 months (80% vs 22%; P<0.01) and at 12 months old (80% vs 13%; P<0.01) than non-overweight infants at 18 months. The spearman correlation analysis demonstrated that weight-for-length Z score at 18 months old was positively correlated with birth weight and weight gain between 0 to 6 months, 7 to 12 months and 13 to 18 months (P<0.05). The strongest correlation was observed between weight gain form 0 to 6 months and weight-for-length Z score at 18 months old (r=0.597, P<0.01). CONCLUSIONS: More attention should be given to the aspect of rapid weight gain in the first 6 months of life in macrosomic infants, especially males, to prevent obesity in early childhood.
2012 Vol. 14 (06): 409-412 [Abstract] ( 4730 ) [HTML 1KB] [PDF 911KB] ( 1255 )
413 LUO Fei-Fei, YANG Di-Yuan, CHEN Pan, HUA Zi-Yu
Efficacy of pulmonary surfactant therapy in neonates with meconium aspiration syndrome: a meta-analysis
OBJECTIVE: The efficacy of pulmonary surfactant (PS) replacement therapy for meconium aspiration syndrome (MAS) remains controversial. This study aimed to evaluate the efficacy of PS therapy in neonates with MAS by a meta-analysis. METHODS: Randomized controlled trials (RCTs) on the treatment of MAS with PS were searched electronically in medical debases including PubMed, Science Citation Index, The Cochrane Central Register of Controlled Trials, Ovid, EBSCOhost, BIOSIS previews, Chinese BioMedical Literature Database, Wanfang Database and VIP Chinese Sci-Tech Periodical Database. The Cochrane Handbook 5.0.2 was employed to evaluate methodological quality. RevMan 5.0.25 software was used for the meta-analysis. RESULTS: Eight RCTs including 512 MAS neonates (257 cases in the PS treatment group and 255 cases in the control group) were enrolled in this meta-analysis. The meta-analysis showed that PS treatment reduced oxygenation index (MD=-2.59; 95%CI: -4.33, -0.86; P=0.003), increased arterial oxygen/alveolar oxygen ratio (MD=0.05; 95%CI: 0.05, 0.06; P<0.00001), shortened hospitalization days (MD=-4.94; 95%CI: -7.44, -2.44; P=0.0001) and decreased mortality rate (OR=0.47; 95%CI: 0.24, 0.93; P=0.03) significantly. There were no statistical differences in the durations of mechanical ventilation and oxygen therapy, and the incidences of air leak, pulmonary hemorrhage and intracranial hemorrhage between the PS treatment and control groups. CONCLUSIONS: Currently published evidence from RCTs suggests that PS replacement therapy is effective for MAS, however because of the limited quantity and quality of trials enrolled in the study, further evidence from RCTs is needed to prove the efficacy.
2012 Vol. 14 (06): 413-417 [Abstract] ( 6560 ) [HTML 1KB] [PDF 939KB] ( 2029 )
454 HUANG Jing-Jing, LIU Xuan, WANG Xing-Qi, YANG Li-Hua, QI Da-Shi, YAO Rui-Qin
Effects of quercetin on the learning and memory ability of neonatal rats with hypoxic-ischemic brain damage Hot!
OBJECTIVE: To study the effects of quercetin, a flavonoid, on the learning and memory ability of 3-day-old neonatal rats with hypoxic-ischemic brain white matter damage (WMD). METHODS: Sixty 3-day-old Sprague-Dawley rats were randomly divided into four groups: control, WMD model,and quercetin treatment groups (20 and 40 mg/kg). There were 15 rats in each group. Rats in the WMD model and the two quercetin treatment groups were subjected to right common carotid artery ligation followed by 2 hrs of exposure to 8% O2 to induce periventricular white matter injury. After the operation quercetin was administered daily in the two quercetin treatment groups for 6 weeks. Six weeks later, Morris water maze and open-field tests were carried out to test memory and learning ability as well as behavior and cognition. RESULTS: From the second day of training, escape latency in the Morris water maze test was more prolonged in the WMD model group than in the control group (P<0.01). The escape latency in the two quercetin treatment groups was shortened significantly compared with the WMD model group (P<0.05). The WMD model group crossed the original platform fewer times compared with the control and quercetin treatment groups (P<0.05). The open-field test indicated that the number of rearings increased and time spent in the centre was extended in the WMD model group compared with the control group. Compared with the WMD model group, the number of rearings was significantly reduced (P<0.05) and time spent in the centre was significantly shortened in the quercetin treatment groups (P<0.05). CONCLUSIONS: Quercetin treatment can improve memory and learning ability as well as cognitive ability in neonates with WMD, suggesting that quercetin protects against WMD resulting from hypoxia-ischemia.
2012 Vol. 14 (06): 454-457 [Abstract] ( 5469 ) [HTML 1KB] [PDF 1210KB] ( 1441 )
475 XU Jian, HAN Yan-Yan, SUN Jing-Hui
Advance in research on endocardial fiborelastosis
Endocardial fiborelastosis (EFE) is a common infantile myocardiosis. The pathogenesis of EFE may be associated with viral infection, genetic factors, immune factors and endocardial dysplasia. The fundamental pathological changes of EFE include hyperplasia of endocardium elastic fibers and collagen fibers. Acute EFE is a frequent type. Clinical manifestations of EFE are non-specific and children with EFE mainly present with congestive heart failure. Echocardiography is very helpful to the diagnosis of EFE. It is necessary to differentiate EFE from pneumonia complicated by acute congestive heart failure, viral myocarditis and anomalous origin of the left coronary artery. Treatment is meant to control symptoms of congestive heart failure. Patients who respond well to digitalis and have good medication compliance have a favorable prognosis.
2012 Vol. 14 (06): 475-480 [Abstract] ( 5600 ) [HTML 1KB] [PDF 993KB] ( 1874 )
CLINICAL EXPERIENCE
458 YANG Feng-Hua, ZHANG Jun-Mei, WANG Hua
Clinical analysis of cerebral infarction following mild head trauma in children
No abstract available
2012 Vol. 14 (06): 458-461 [Abstract] ( 3958 ) [HTML 1KB] [PDF 1195KB] ( 1186 )
462 LI Hai-Yan, XU Zhi-Wei, CHEN Yi-Ping, DONG Lin
Clinical analysis of 10 cases of childhood acute leukemia complicated by varicella
No abstract available
2012 Vol. 14 (06): 462-463 [Abstract] ( 3164 ) [HTML 1KB] [PDF 882KB] ( 1209 )
CASE REPORT
464 GUO Li, SONG Hua, MAO Jun-Qing, TANG Yong-Min
Immune thrombocytopenia following successful chemotherapy of acute leukemia: report of 2 cases
No abstract available
2012 Vol. 14 (06): 464-465 [Abstract] ( 3523 ) [HTML 1KB] [PDF 886KB] ( 1164 )
466 WANG Hua, XIONG Ying, MU De-Zhi
Treatment of neonatal diabetes mellitus: experience of one case
No abstract available
2012 Vol. 14 (06): 466-467 [Abstract] ( 3589 ) [HTML 1KB] [PDF 886KB] ( 1043 )
468 CHEN Yin-Bo, LIANG Dong, HAO Xiao-Sheng
Acquired epileptiform opercular syndrome in a child
No abstract available
2012 Vol. 14 (06): 468-469 [Abstract] ( 3258 ) [HTML 1KB] [PDF 1474KB] ( 953 )
REVIEW
470 WANG Ye-Feng, HUANG Xi-Yong
Research advance of brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis and treatment of pediatric cardiovascular diseases
Brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (NT-proBNP) are important biomarkers for pediatric cardiovascular diseases. Peptide levels are associated with age and gender. Current studies have shown that BNP and NT-proBNP are valuable in the diagnosis of heart failure, with a high specificity and sensitivity. They also contribute to differentiating heart failure from acute respiratory distress induced by simple pulmonary factors. In addition, BNP and NT-proBNP are useful in the evaluation of disease severity and treatment guidance in children with pulmonary hypertension, cardiomyopathy and Kawasaki disease. Current limitations include the relatively small sample size of the study, the detection method and a range of normal values that are not completely uniform.
2012 Vol. 14 (06): 470-474 [Abstract] ( 5128 ) [HTML 1KB] [PDF 927KB] ( 1779 )
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