A multicenter survey of antibiotic use in very and extremely low birth weight infants in Hunan Province
WANG Ming-Jie1, YUE Shao-Jie1, LIN Jin2, GAO Xi-Rong3, PENG Xiao-Ming3, CHEN Meng-Yu3, PENG Hua-Bao4, CAO Bei5, ZENG Yun-Qing5, WANG Shu-Lian6, WEN Bo6, HUANG Xi-Lin7, LI Xiao-Ping7, ZHANG Ai-Zhen8, CAO Ting8, CHEN Yi-Hua9, CHEN Tie-Qiang10, YE Chun-Hua10, BO Tao11, JIANG De-Lin12, HUANG Xiu-Qun13, REN Na-Fang13, TAO Long-Zhang14, YAO Fang14, TIAN Chang-Jun15, LI Hong-Ming16, ZHANG Ai-Min17, HUANG Fu-Rong17, ZHANG Wei-Guo18, CHEN Xiang-Hong19, LIU Yu-Chan19, LIU Zheng-Lin19, XU Yan-Shan20, MING Jing-Song20, CHEN Li21, ZHU Ning-Yi21, HE Jun-Min22, YI Sai-Jun22, WANG Tuan-Mei23, LI Zhao-Hui24, WANG Gui-Tian25
WANG Ming-Jie, YUE Shao-Jie, LIN Jin, GAO Xi-Rong, PENG Xiao-Ming, CHEN Meng-Yu, PENG Hua-Bao, CAO Bei, ZENG Yun-Qing, WANG Shu-Lian, WEN Bo, HUANG Xi-Lin, LI Xiao-Ping, ZHANG Ai-Zhen, CAO Ting, CHEN Yi-Hua, CHEN Tie-Qiang, YE Chun-Hua, BO Tao, JIANG De-Lin, HUANG Xiu-Qun, REN Na-Fang, TAO Long-Zhang, YAO Fang, TIAN Chang-Jun, LI Hong-Ming, ZHANG Ai-Min, HUANG Fu-Rong, ZHANG Wei-Guo, CHEN Xiang-Hong, LIU Yu-Chan, LIU Zheng-Lin, XU Yan-Shan, MING Jing-Song, CHEN Li, ZHU Ning-Yi, HE Jun-Min, YI Sai-Jun, WANG Tuan-Mei, LI Zhao-Hui, WANG Gui-Tian
Abstract：Objective To investigate the current status of antibiotic use for very and extremely low birth weight (VLBW/ELBW) infants in neonatal intensive care units (NICUs) of Hunan Province. Methods The use of antibiotics was investigated in multiple level 3 NICUs of Hunan Province for VLBW and ELBW infants born between January, 2017 and December, 2017. Results The clinical data of 1 442 VLBW/ELBW infants were collected from 24 NICUs in 2017. The median antibiotic use duration was 17 days (range:0-86 days), accounting for 53.0% of the total length of hospital stay. The highest duration of antibiotic use was up to 91.4% of the total length of hospital stay, with the lowest at 14.6%. In 16 out of 24 NICUs, the antibiotic use duration was accounted for more than 50.0% of the hospitalization days. There were 113 cases with positive bacterial culture grown in blood or cerebrospinal fluid, making the positive rate of overall bacterial culture as 7.84%. The positive rate of bacterial culture in different NICUs was significantly different from 0% to 14.9%.The common isolated bacterial pathogens Klebsiella pneumoniae was 29 cases (25.7%); Escherichia coli 12 cases (10.6%); Staphylococcus aureus 3 cases (2.7%). The most commonly used antibiotics were third-generation of cephalosporins, accounting for 41.00% of the total antibiotics, followed by penicillins, accounting for 32.10%, and followed by carbapenems, accounting for 13.15%. The proportion of antibiotic use time was negatively correlated with birth weight Z-score and the change in weight Z-score between birth and hospital discharge (rs=-0.095, -0.151 respectively, P < 0.01), positively correlated with death/withdrawal of care (rs=0.196, P < 0.01). Conclusions Antibiotics used for VLBW/ELBW infants in NICUs of Hunan Province are obviously prolonged in many NICUs. The proportion of routine use of third-generation of cephalosporins and carbapenems antibiotics is high among the NICUs.
WANG Ming-Jie,YUE Shao-Jie,LIN Jin et al. A multicenter survey of antibiotic use in very and extremely low birth weight infants in Hunan Province[J]. CJCP, 2020, 22(6): 561-566.
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