目的：探讨晚期早产儿(late preterm infant, LPI) 早产相关危险因素及临床常见并发症。方法：对287例LPI临床资料进行回顾性分析，同时随机抽取288例同期住院的足月新生儿作对照，应用logistic回归分析的方法筛选LPI早产的危险因素，并分析其常见临床并发症的发生等情况。结果：Logistic回归显示双胎、妊娠期糖尿病、先兆子癎及子癎、前置胎盘、胎盘早剥及胎膜早破为LPI早产发生的危险因素。LPI住院时间明显长于足月儿，其各系统并发症发生率均较高，其中以贫血、吸入性肺炎、低血糖症、颅内出血等为主。结论：LPI生后易发生多种并发症，应注意密切观察，及时救治。避免围产期异常分娩因素的发生是降低LPI出生的关键。
Abstract
OBJECTIVE: To investigate the risk factors for preterm birth and complications in late preterm infants. METHODS: The clinical data of 287 late preterm infants were retrospectively studied. Two hundred and eighty-eight term infants served as the control group. Logistic regression analysis was used to identify risk factors associated with late preterm birth. The common complications in late preterm infants were investigated. RESULTS: Several significant risk factors for late preterm birth were identified by logistic regression analysis: twin pregnancy, gestational diabetes mellitus, eclampsia or preeclampsia, placenta previa, placental abruption and premature rupture of membranes. The duration of hospitalization in late preterm infants was longer than that in term infants. The complications were common in late preterm infants, with a high prevalence of anemia, aspiration pneumonia, hypoglycemia and intracranial hemorrhage. CONCLUSIONS: The late preterm infants are much more likely to suffer various complications. It is important to reduce the incidence of late preterm births by decreasing perinatal risk factors above mentioned.
关键词
危险因素 /
并发症 /
晚期早产儿
Key words
Risk factor /
Complication /
Late preterm infant
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参考文献
［1］Loftin RW, Habli M, Snyder CC, Cormier CM, Lewis DF, Defranco EA. Late preferm birth［J］. Rev Obstet Gynecol, 2010, 3(1): 10-19.
［2］Tomashek KM, Shapiro-Mendoza CK, Weiss J, Kotelchuck M, Barfield W, Evans S, et al. Early discharge among late preterm and term newborns and risk of neonatal morbidity［J］.Semin Perinatol, 2006, 30(2):61-68.
［3］Wang ML, Dorer DJ, Fleming MP, Catlin EA. Clinical outcomes of near-term infants［J］. Pediatrics, 2004, 114(2): 372-376.
［4］Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S, et al. Births: final data for 2005［J］. Natl Vital Stat Rep, 2007, 56(6): 1-103.
［5］Martin JA, Kung HC, Mathews TJ, Hoyert DL, Strobino DM, Guyer B,et al. Annual summary of vital statistics: 2006［J］. Pediatrics, 2008, 121(4): 788-801.
［6］Lubow JM, How HY, Habli M, Maxwell R, Sibai BM. Indications for delivery and short-term neonatal outcomes in late preterm as compared with term births［J］. Am J Obstet Gynecol, 2009, 200(5): e30-e33.
［7］王红,周丛乐,王红梅,汤泽中,候新琳,刘云峰，等.早产儿脑白质损伤与母亲先兆子癎关系的研究［J］.中国儿童保健杂志，2007，15（2）：136-140.
［8］李丽军. 晚期早产胎膜早破166例分析［J］. 天津医药,2009,37(8):707-708.
［9］彭华,童笑梅. 早产儿贫血的相关因素分析［J］.中国当代儿科杂志,2008,10(5):589-592.
［10］杨光涛,刘国军.早产儿视网膜病的防治与新进展［J］.中国新生儿科杂志, 2008,23(2): 122-124.
［11］高喜容,吴运芹,李磊,黄玫,刘新晖.早产儿慢性肺疾病临床分析［J］.中国当代儿科杂志, 2008, 10(4): 539-540.
［12］Kinney HC. The near-term (late preterm) human brain and risk for periventricular leukomalacia: a review［J］. Semin Perinatol, 2006, 30(2): 81-88.
［13］刘赛红,胡伟,肖娟,曹蓓,谢高梅,冯彬彬. 302例晚期早产儿围生期并发症分析［J］.实用预防医学，2009,16（6）：1854-1856.
［14］陈丹，毛健，李娟，刘丽，张懿. 晚期早产儿脑白质损伤临床特点及磁共振影像学发现［J］. 中国当代儿科杂志，2010, 12(5):321-326.
［15］Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran O, Tekinalp G,et al. Incidence, course, and prediction of hyperbilirubinemia in nearterm and term newborns［J］. Pediatrics, 2004, 113(4):775-780.
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