Abstract：Objective To investigate the prevalence, clinical characteristics, treatment, and prognosis of neonatal respiratory failure (NRF) in Huai'an, Jiangsu Province, China, in 2010. Methods The clinical data of all NRF cases inthe hospitals of Huai'an in 2010 were prospectively collected and analyzed using descriptive epidemiological methods.Results Among 60 986 live births in Huai'an in 2010, there were 556 (0.91%) cases of NRF. The average birth weightof newborns with NRF was 2 433±789 g, with 53.8% determined as low birth weight and 64.1% as preterm. The majorcauses of NRF were respiratory distress syndrome, pneumonia, asphyxia, sepsis, and pulmonary hemorrhage. Among thenewborns with NRF, 23.7% were accompanied by certain birth defects. Fourteen percent of newborns with NRF received pulmonary surfactant (PS) therapy, and the median time of the first dose of PS was 5 hours (range:0-51 hours). Nasalcontinuous positive airway pressure treatment, conventional mechanical ventilation, and high-frequency ventilation wereused in 67.9%, 33.3%, and 13.7% of patients, respectively. The cure and improvement rate of NRF patients was 73.9%(411/556), and the mortality rate was 22.5% (125/556). The average hospitalization expenses were 9 270 (range:196-38182) Yuan. Conclusions High morbidity, high mortality and high medical costs make NRF a serious challenge in Huai'an. It is essential to improve the quality of perinatal care and develop new techniques and new models in neonatal respiratory therapy in order to reduce the morbidity and mortality of NRF.
PAN Zhao-Jun,DING Su-Fang,GAO Zi-Bo et al. A population-based epidemiological survey of neonatal respiratory failure in Huai'an City of Jiangsu Province, in 2010[J]. CJCP, 2014, 16(11): 1138-1142.
Lee SK, McMillan DD, Ohlsson A, et al. Variations inpractice and outcomes in the Canadian NICU network, 1996-1997[J]. Pediatrics, 2000, 106(5):1070-1079.
[2]
Rubaltelli FF, Bonafe L, Tangucci M, et al. Epidemiology of neonatal acute respiratory disorders. A multicenter study on incidence and fatality rates of neonatal acute respiratory disorders according to gestational age, maternal age, pregnancy complications and type of delivery[J]. Biol Neonate, 1998, 74(1):7-15.
[3]
Qian LL, Liu CQ, Zhuang WZ Y, et al. Neonatal respiratory failure, a 12-month clinical epidemiologic study in 2004-2005 in China[J]. Pediatrics, 2008, 121(5):e1115-e1124.
Ma L, Liu C, Sun B. Hebei Neonatal Network Study Group. Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China[J]. Neonatology, 2011, 100 (1):14-22.
[8]
Angus DC, Linde-Zwirble WT, Clermont G, et al. Epidemiology of neonatal respiratory failure in the United States projections from California and New York[J]. Am J Resp Care Med, 2001, 164(7):1154-1160.
Chen KT1, Ringer S, Cohen AP, et al. The role of intrapartum fever in identifying asymptomatic term neonates with early onset neonatal sepsis[J]. J Perinatol, 2002, 22(8):653-657.
