Abstract：Objective To investigate the survival quality of infants conceived by in vitro fertilization (IVF) and to identify the factors that cause birth defects and neonatal complications in IVF infants. Methods The study included 150 IVF infants (IVF group) and 200 naturally conceived infants (control group). Indicators such as birth situation, gestational disease, birth defects, and neonatal complications were compared between groups. The influencing factors for birth defects and neonatal complications were analyzed by non-conditional logistic regression analysis. Results Compared with the control group, the IVF group had increased incidences of twin pregnancy and low birth weight (P<0.01) but decreased average birth weight (P<0.05). In the IVF group, the mother's age was elder, with higher incidence of cesarean section, premature rupture of membranes, and pregnancy complications, as compared with the control group (P<0.05). There was no significant difference in the incidence of birth defects between the two groups (P>0.05). The IVF group had higher incidence rates of low birth weight and neonatal scleroderma (P<0.05), with a longer hospital stay (P<0.01), as compared with the control group. The non-conditional logistic regression analysis indicated that IVF, prematurity, twin pregnancy, and pregnancy complications were risk factors for low birth weight (P<0.05). Conclusions There is no significant difference in the incidence of birth defects between IVF and naturally conceived infants. However, IVF infants have higher incidences of twin pregnancy and low birth weight, with a longer hospital stay, as compared with naturally conceived infants. Natural conceiving, avoiding prematurity, twin pregnancy, and pregnancy complications will reduce the incidence of low birth weight.
XU Xiao-Yan,YANG Jing-Hui,MA Xin-Mei et al. Neonatal complications and birth defects in infants conceived by in vitro fertilization[J]. CJCP, 2015, 17(4): 350-355.
Zollner U, Dietl J. Perinatal risks after IVF and ICSI[J]. J Perinat Med, 2013, 41(1): 17-22.
[2]
Sazonova A, Kallen K, Thurin-Kjellberg A, et al. Neonatal and 第17 卷第4 期 2015年4 月中国当代儿科杂志 Chin J Contemp Pediatr Vol.17 No.4 Apr. 2015 ·355· maternal outcomes comparing women undergoing two in vitro fertilization (IVF) singleton pregnancies and women undergoing one IVF twin pregnancy[J]. Fertil and Steril, 2013, 99(3): 731- 737.
Aboulghar M, Islam Y. Twin and preterm labor: prediction and treatment[J]. Curr Obstet Gynecol Rep, 2013, 2(4): 232-239.
[9]
Van Heesch MM, Evers JL, Dumoulin JC, et al. A comparison of perinatal outcomes in singletons and multiples born after in vitro fertilization or intracytoplasmic sperm injection stratified for neonatal risk criteria[J]. Acta Obstet Gynecol Scand, 2014, 93( 3): 277-286.
[10]
Lehnen H, Schäfer S, Reineke T, et al. Twin pregnancies conceived spontaneously and by ART (Assisted Reproductive Technologies)-a retrospective analysis and review[J]. Geburtshilfe Frauenheilkd, 2011, 71(8): 669-676.
[11]
Sazonova A, Kallen K, Thurin-Kjellberg A, et al. Obstetric outcome after in vitro fertilization with single or double embryo transfer[J]. Hum Reprod, 2011, 26(2): 442-450.
[12]
Talaulikar VS, Arulkumaran S. Reproductive outcomes after assisted conception[J]. Obstet Gynecol Surv, 2012, 67: 566-583.
[13]
Hansen M, Kurinczuk JJ, Milne E, et al. Assisted reproductive technology and birth defects: a systematic review and metaanalysis[ J]. Hum Reprod Update, 2013, 19(4): 330-353.
[14]
Davies MJ, Moore VM, Willson KJ, et al. Reproductive technologies and the risk of birth defects[J]. N Engl J Med, 2012, 366(19): 1803-1813.
[15]
Wen J, Jiang J, Ding C, et al. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis[J]. Fertil Steril, 2012, 97(6): 1331-1337.
[16]
Moses XJ, Torres T, Rasmussen A, et al. Congenital anomalies identified at birth among infants born following assisted reproductive technology in Colorado[J]. Birth Defects Res A Clin Mol Teratol, 2014, 100(2): 92-99.
[17]
Talaulikar VS, Arulkumaran S. Maternal, perinatal and longterm outcomes after assisted reproductive techniques (ART): implications for clinical practice[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 170(1): 13-19.
[18]
Fan C, Sun Y, Yang J, et al. Maternal and neonatal outcomes in dichorionic twin pregnancies following IVF treatment: a hospital-based comparative study[J]. Int J Clin Exp Pathol, 2013, 6(10): 2199-2207.
