Long-term efficacy of CAMSBDH-ALL chemotherapy protocol for the treatment of childhood acute lymphoblastic leukemia
CHEN Xiao-Juan, ZOU Yao, CHEN Yu-Mei, YANG Wen-Yu, WANG Shu-Chun, GUO Ye, ZHANG Li, RUAN Min, LIU Xiao-Ming, LIU Fang, LIU Tian-Feng, ZHANG Jia-Yuan, Qi Ben-Quan, CHANG Li-Xian, ZHU Xiao-Fan
Institute of Hematology, Blood Disease Hospital, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College, Tianjin 300020, Chian
Abstract Objective To study the long-term efficacy of CAMSBDH-ALL chemotherapy protocol for the treatment of childhood acute lymphoblastic leukemia (ALL). Methods Three hundred and eighteen children who were newly diagnosed with ALL between January 1999 and December 2007 were enrolled in this study. Among the 318 children, 83 children who hospitalized before December 2002 were treated with CAMSBDH-ALL99 protocol, including 48 patients of standard risk and 35 patients of high risk. The patients (n=235; 131 in standard risk and 104 in high risk) who hospitalized after December 2002 were treated with CAMSBDH-ALL03 protocol. Patients in the CAMSBDHALL99 protocol group were treated with conventional chemotherapy. CAMSBDH-ALL03 protocol was modified based on the CAMSBDH-ALL99 protocol. Results The long-term overall survival (OS) and event-free-survival (EFS) in the CAMSBDH-ALL03 group was significantly higher than in the CAMSBDH-ALL99 (P<0.01). The long-term OS and EFS of standard risk and high risk patients in the CAMSBDH-ALL03 protocol group were significantly higher than in the CAMSBDH-ALL99 protocol group (P<0.01). The CAMSBDH-ALL03 protocol group showed a significantly lower recurrence rate (28.9%) than in the CAMSBDH-ALL99 protocol group (50.6%) (P<0.05). The mortality rate in the CAMSBDH-ALL03 protocol group was 28.5% vs 56.6% in the CAMSBDH-ALL99 protocol group (P<0.05). Conclusions The therapeutic effect of the CAMSBDH-ALL03 protocol is supior to the CAMSBDH-ALL99 protocol group for childhood ALL, with a higher long-term survival rate.
CHEN Xiao-Juan,ZOU Yao,CHEN Yu-Mei et al. Long-term efficacy of CAMSBDH-ALL chemotherapy protocol for the treatment of childhood acute lymphoblastic leukemia[J]. CJCP, 2014, 16(10): 1019-1024.
CHEN Xiao-Juan,ZOU Yao,CHEN Yu-Mei et al. Long-term efficacy of CAMSBDH-ALL chemotherapy protocol for the treatment of childhood acute lymphoblastic leukemia[J]. CJCP, 2014, 16(10): 1019-1024.
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