Abstract Objective To study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children. Methods A case-control study was performed on 184 children with KD and 206 normal controls. The polymorphisms of two SNPs in CD40 gene were detected using PCR-RFLP. Results There were no significant differences in the genotype distribution and allele frequency of SNP rs4810485 in CD40 gene between the KD and normal groups (P>0.05). The genotype distribution of SNP rs1535045 in CD40 gene in the KD group was significantly different from the control group (POR=1.592, 95%CI: 1.182-2.144, P=0.004). There were no association between the polymorphisms of the two SNPs and coronary artery lesions (P>0.05). Conclusions SNP rs1535045 may be associated with the development of KD in Han Chinese children, while SNP rs4810485 may not.
CHENG Shou-Chao,CHENG Yan-Yang,WU Jin-Long. Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease[J]. CJCP, 2014, 16(10): 1025-1028.
CHENG Shou-Chao,CHENG Yan-Yang,WU Jin-Long. Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease[J]. CJCP, 2014, 16(10): 1025-1028.
Lee YC, Kuo HC, Chang JS, et al. Two new susceptibility locifor Kawasaki disease identified through gnome-wide associationanalysis[J]. Nat genetics, 2012, 44(5): 522-525.
[4]
Kuo HC, Chao MC, Hsu YW, et al. CD40 Gene polymorphismsassociated with susceptibility and coronary artery lesions ofKawasaki disease in the Taiwanese population[J]. ScientificWorld Journal, 2012, 2012: 520865.
[5]
Yanagawa HD, Yanagawa HA. Epidemiology of Kawasakidisease: a 30-year achievement[M]. Tokoyo: Shindan-To-Chiryosha, 2004: 24-32.
[6]
Research Committee on Kawasaki disease. Report ofsubcommittee on standardization of diagnostic criteria andreporting of coronary artery lesions in Kawasaki disease Tokyo:ministry of health and welfare[R]. 1984
Ouchi K, Suzuki Y, Shirakawa T, et al. Polymorphism ofSLC11A1 (NRAMP1) gene confers susceptibility to Kawasakidisease[J]. J Infect Dis, 2003, 187(2): 326-329.
[12]
Wang CL, Wu YT, Liu CA, et al. Expression of CD40 ligand onCD4+T cell and platelets correlated to the coronary artery lesionand disease progress in Kawasaki disease[J]. Padiatrics, 2003,111(2): e140-e147.
[13]
Onouchi Y, Onoue S, Tamari M, et al. CD40 ligand gene andKawasaki disease[J]. Eur J Humgenet, 2004, 12(12): 1062-1068.
[14]
Rozin L, Koehler SA, Shakir A, et al. Kawasaki disease: areview of pathologic features of stage IV disease and two casesof sudden death among asymptotic young adults[J]. Am JForensic Med Pathol, 2003, 24(1): 45-50.
