Abstract Objective To screen biomarkers which can be used as an auxiliary method in the diagnosis of Henoch-Schönlein purpura (HSP) and to evaluate their diagnostic values by receiver operating characteristic (ROC) curve analysis.Methods A total of 127 children diagnosed with HSP between April 2012 and March 2014 were included in the HSP group and an equal number of healthy children were included in the control group. Twelve parameters, i.e., serum amyloid protein A (SAA), interleukin-6 (IL-6), immunoglobulins (IgA, IgG, IgM, and IgE), C-reactive protein (CRP), white blood cell (WBC) count, complements C3 and C4, anti-streptolysin O, and ferritin, were analyzed. The values of the screened biomarkers for diagnosis of HSP were assessed by ROC curve analysis.Results The HSP group had significantly higher levels of SAA, IL-6, CRP, WBC, IgA, and IgM than the control group (PPConclusions SAA, IgA, IgM, WBC, and IL-6 are valuable biomarkers for clinical diagnosis of HSP and among them SAA seems to be the best one.
Nalbantoglu S, Tabel Y, Mir S, et al. Association between RAS gene polymorphisms (ACE I/D, AGT M235T) and Henoch-Schönlein purpura in a Turkish population[J]. Dis Markers, 2013, 34(1):23-32.
Kraft DM, Mckee D, Scott C. Henoch-Schönlein purpura:a review[J]. Am Fam Physician, 1998, 58(2):405-408, 411.
[4]
王卫平. 儿科学[M]. 第8 版. 北京:人民卫生出版社, 2013:190-192.
[5]
5Rho YH, Chung CP, Oeser A, et al. Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis[J]. Arthritis Rheum, 2009, 61(11):1580-1585.
[6]
Targońska-Stępniak B, Majdan M. Serum amyloid A as a marker of persistent inflammation and an indicator of cardiovascular and renal involvement in patients with rheumatoid arthritis[J]. Mediators Inflamm, 2014, 2014:793628.
He X, Zhao Y, Li Y, et al. Serum amyloid A levels associated with gastrointestinal manifestations in Henoch-Schönlein Purpura[J]. Inflammation, 2012, 35(4):1251-1255.
[9]
Yuan LP, Bo Y, Ling L, et al. Expression of T-cell immunoglobulin-and mucin-domain-containing molecule-3 on lymphocytes from Henoch-Schöenlein Purpura patients[J]. Iran J Pediatr, 2013, 23(3):345-348.
