Abstract Objective To study the correlation between serum procalcitonin (PCT) level and severity of infant muggy syndrome (IMS) and the predictive value of PCT in the development of multiple organ dysfunction syndrome (MODS) in children with IMS.Methods Fifty children with IMS were classified into two groups according to the presence of MODS:MODS (n=29) and non-MODS (n=21). According to a 30-day follow-up result, they were classified into survival (n=36) and deceased groups (n=14). Vital signs, routine biological measurements (arterial blood gas, blood routine, CRP, liver and kidney functions, myocardial enzyme and so on) and the disease severity evaluated by the Pediatric Critical Illness Score (PCIS) within 24 hours of admission were recorded. Serum levels were measured using the semi-quantitative PCT-Q test within 24 hours of admission.Results Forty-seven children (94%) had elevated serum PCT levels (≥0.5 ng/mL) at admission. There were lower PCIS scores, higher rates of MODS and higher levels of serum PCT in deceased patients than survivors (Pr=-0.84, PPPConclusions Serum PCT level at admission is correlated with the severity of IMS and it may be an early predictive marker of MODS.
CAI Xiao-Fang,SUN Ji-Min,LI Wen-Bin. Clinical value of serum procalcitonin in evaluating severity of infant muggy syndrome[J]. CJCP, 2015, 17(9): 922-926.
CAI Xiao-Fang,SUN Ji-Min,LI Wen-Bin. Clinical value of serum procalcitonin in evaluating severity of infant muggy syndrome[J]. CJCP, 2015, 17(9): 922-926.
Reinhart K, Meisner M. Biomarkers in the critically ill patient:procalcitonin[J]. Crit Care Clin, 2011, 27(2):253-263.
[2]
Mathew B, Roy DD, Kumar TV. The use of procalcitonin as a marker of sepsis in children[J]. J Clin Diagn Res, 2013, 7(2):305-307.
[3]
Jekarl DW, Lee SY, Lee J, et al. Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis[J]. Diagn Microbiol Infect Dis, 2013, 75(4):342-347.
[4]
Azevedo JR, Torres OJ, Czeczko NG, et al. Procalcitonin as a prognostic biomarker of severe sepsis and septic shock[J]. Rev Col Bras Cir, 2012, 39(6):456-461.
Goldstein B, Giroir B, Randolph A, et al. International pediatric sepsis consensus conference:definitions for sepsis and organ dysfunction in pediatrics[J]. Pediatr Crit Care Med, 2005, 6(1):2-8.
Barati M, Alinejad F, Bahar MA, et al. Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases[J]. Burns, 2008, 34(6):770-774.
