Abstract Objective To reveal the current research status on stem cell transplantation in the treatment of neonates with hypoxic-ischemic encephalopathy (HIE), and to summarize the recent hotspots of the research in this field.Methods Using the key words of "stem cells" and "HIE", a computerized search was performed for the articles in English published before June 1, 2018 in PubMed, EMBASE, and Web of Science. Microsoft Office Excel 2013 was used for the statistical analysis of key words. Bicomb 2.0 and VOSviewer 1.6.6 were used for the cluster analysis of hot words and plotting of knowledge maps, respectively.Results A total of 106 articles were included and 43 high-frequency key words were extracted. The words of "cell transplantation" and "hypoxia-ischemia" were in the core position of the co-word map. The cluster analysis showed that the studies of stem cell transplantation in the treatment of neonatal HIE mainly focused on umbilical cord blood cell transplantation (32.6%), mesenchymal stem cells and neural stem cells (29.5%), perinatal brain injury (28.1%), and other topics (9.8%).Conclusions In the current studies of stem cell transplantation in the treatment of neonatal HIE, umbilical cord blood cell transplantation, mesenchymal stem cells, neural stem cells, and perinatal brain injury are popular research topics at different levels.
LI Wen-Xing,TANG Jun,ZOU Rong et al. A visualization analysis of current research on stem cell transplantation in the treatment of neonatal hypoxic-ischemic encephalopathy[J]. CJCP, 2018, 20(12): 1002-1007.
LI Wen-Xing,TANG Jun,ZOU Rong et al. A visualization analysis of current research on stem cell transplantation in the treatment of neonatal hypoxic-ischemic encephalopathy[J]. CJCP, 2018, 20(12): 1002-1007.
Donega V, Nijboer CH, van Velthoven CT, et al. Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse[J]. Pediatr Res, 2015, 78(5):520-526.
[2]
Chicha L, Smith T, Guzman R. Stem cells for brain repair in neonatal hypoxia-ischemia[J]. Childs Nerv Syst, 2014, 30(1):37-46.
Cotten CM, Murtha AP, Goldberg RN, et al. Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy[J]. J Pediatr, 2014, 164(5):973-979. e1.
[10]
van Velthoven CT, Kavelaars A, van Bel F, et al. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration[J]. Brain Behav Immun, 2010, 24(3):387-393.
[11]
Pimentelcoelho PM, Mendezotero R. Cell therapy for neonatal hypoxic-ischemic encephalopathy[J]. Stem Cells Dev, 2010, 19(3):299-310.
[12]
Xie B, Ping G, Wang W, et al. Therapeutic effects of human umbilical cord mesenchymal stem cells transplantation on hypoxic ischemic encephalopathy[J]. Am J Transl Res, 2016, 8(7):3241-3250.
[13]
Archambault J, Moreira A, Mcdaniel D, et al. Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy:a systematic review and meta-analysis of preclinical studies[J]. PLoS One, 2017, 12(12):e0189895.
Haus DL, Lópezvelázquez L, Gold EM, et al. Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury[J]. Exp Neurol, 2016, 281:1-16.
[16]
Azzopardi D, Strohm B, Marlow N, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes[J]. N Engl J Med, 2014, 371(2):140-149.
[17]
Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy:synthesis and meta-analysis of trial data[J]. BMJ, 2010, 340:c363.
[18]
Ahn SY, Chang YS, Sung DK, et al. Hypothermia broadens the therapeutic time window of mesenchymal stem cell transplantation for severe neonatal hypoxic ischemic encephalopathy[J]. Sci Rep, 2018, 8(1):7665.
[19]
Park WS, Sung SI, Ahn SY, et al. Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy[J]. PLoS One, 2015, 10(3):e0120893.