Abstract Most critically ill children are in a state of serious stress and tend to develop malnutrition, which may reduce the body's ability to fight against diseases and repair damaged tissues and thus aggravate their conditions. Reasonable and effective nutritional support for critically ill children can improve their nutritional status and prognosis, and so it is necessary to offer nutritional support for critically ill children. This article reviews the research on nutritional support for critically ill children and the current status of clinical application. It also introduces the main methods for nutritional support, including enteral nutrition and parenteral nutrition, and elaborates on the new methods for nutritional support, such as early enteral nutrition, enteral immunonutrition, and supplementary parenteral nutrition, in order to provide a reference for nutritional support for critically ill children.
Reintam A, Parm P, Redlich U, et al. Gastrointestinal failure in intensive care:a retrospective clinical study in three different intensive care units in Germany and Estonia[J]. BMC Gastroenterol, 2006, 6:19.
Briassoulis G, Venkataraman S, Thompson AE. Energy expenditure in critically ill children[J]. Crit Care Mod, 2000, 28(4):1166-1172.
[9]
Moreno YM, Hauschild DB, Barbosa E, et al. Problems with optimal energy and protein delivery in the pediatric intensive care unit[J]. Nutr Clin Pract, 2016, 31(5):673-680.
[10]
Mehta NM, Skillman HE, Irving SY, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient:Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition[J]. Pediatr Crit Care Med, 2017, 18(7):675-715.
[11]
Wong JJ, Ong C, Han WM, et al. Survey of contemporary feeding practices in critically ill children in the Asia-Pacific and the Middle East[J]. Asia Pac J Clin Nutr, 2016, 25(1):118-125.
[12]
Dokken M, Rust En T, Stubhaug A. Indirect calorimetry reveals that better monitoring of nutrition therapy in pediatric intensive care is needed[J]. JPEN J Parenter Enteral Nutr, 2015, 39(3):344-352.
[13]
Beggs MR, Garcia Guerra G, Larsen BMK. Do PICU patients meet technical criteria for performing indirect calorimetry?[J]. Clin Nutr ESPEN, 2016, 15:80-84.
Cook D, Arabi Y. The route of early nutrition in critical illness[J]. N Engl Med, 2014, 371(18):1748-1749.
[16]
Wischmeyer PE. The evolution of nutrition in critical care:how much, how soon[J]. Crit Care, 2013, 17(1):717-722.
[17]
Adaba F, Uppara M, Iqbal F, et al. Chronic cholestasis in patients on parenteral nutrition:the influence of restoring bowel continuity after mesenteric infarction[J]. Eur J Clin Nutr, 2016, 70(2):189-193.
Lee JH, Rogers E, Chor YK, et al. Optimal nutrition therapy in paediatric critical care in the Asia-Pacific and Middle East:a consensus[J]. Asia Pac J Clin Nutr, 2016, 25(4):676-696.
[20]
Singer P, Berger MM, Van den Berghe G, et al. ESPEN guidelines on parenteral nutrition:intensive care[J]. Clin Nutr, 2009, 28(4):387-400.
Kawasaki N, Suzuki Y, Nakayoshi T, et al. Early postoperative enteral nutrition is useful for recovering gastrointestinal motility and maintaining the nutritional status[J]. Surg Today, 2009, 39(3):225-230.
[23]
Kogo M, Nagata K, Morimoto T, et al. Enteral nutrition is a risk factor for airway complications in subjects undergoing noninvasive ventilation for acute respiratory failure[J]. Respir Care, 2017, 62(4):459-467.
[24]
Mehta NM, Bechard LJ, Cahill N, et al. Nutritional practices and their relationship to clinical outcomes in critically ill children-an international multicenter cohort study[J]. Crit Care Med, 2012, 40(7):2204-2211.
[25]
Mehta NM, Bechard LJ, Zurakowski D, et al. Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children:a multicenter, prospective, cohort study[J]. Am J Clin Nutr, 2015, 102(1):199-206.
[26]
Mara J, Gentles E, Alfheeaid HA, et al. An evaluation of enteral nutrition practices and nutritional provision in children during the entire length of stay in critical care[J]. BMC Pediatr, 2014, 14:186.
[27]
Wernerman J. Feeding the gut:how, when and with what-the metabolic issue[J]. Curr Opin Crit Care, 2014, 20(2):196-201.
Moore FA, Moore EE, Kudsk KA, et al. Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding[J]. J Trauma, 1994, 37(4):607-615.
[31]
Mulherin DW, Sacks GS. Uncertainty about the safety of supplemental glutamine:an editorial on "a randomized trial of glutamine and antioxidants in critically ill patients"[J]. Hepatobiliary Surg Nutr, 2015, 4(1):76-79.
[32]
Rice TW, Wheeler AP, Thompson BT, et al. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury[J]. JAMA, 2011, 306(14):1574-1581.
[33]
Bartkowska-Śniatkowska A, Zielińska M, Świder M, et al. Nutritional therapy in paediatric intensive care units:a consensus statement of the Section of Paediatric Anaesthesia and Intensive Therapy the Polish Society of Anaesthesiology and Intensive Therapy, Polish Society of Neonatology and Polish Society for[J]. Anaesthesiol Intensive Ther, 2015, 47(4):267-283.
[34]
Kerklaan D, Fivez T, Mehta NM, et al. Worldwide survey of nutritional practices in PICUs[J]. Pediatr Crit Care Med, 2016, 17(1):10-18.
[35]
Fivez T, Kerklaan D, Mesotten D, et al. Early versus late parenteral nutrition in critically ill children[J]. N Engl J Med, 2016, 374(12):1111-1122.
[36]
Jain AK, Sharma A, Arora S, et al. Preserved gut microbial diversity accompanies upregulation of TGR5 and hepatobiliary transporters in bile acid-treated animals receiving parenteral nutrition[J]. JPEN J Parenter Enteral Nutr, 2017, 41(2):198-207.
[37]
Lei Q, Bi J, Wang X, et al. GLP-2 prevents intestinal mucosal atrophy and improves tissue antioxidant capacity in a mouse model of total parenteral nutrition[J]. Nutrients, 2016, 8(1):1-13.
[38]
Wyer N. Parenteral nutrition:indications and safe management[J]. Br J Community Nurs, 2017, 22(Sup7):S22-S28.
[39]
Chesshyre E, Goff Z, Bowen A, et al. The prevention, diagnosis and management of central venous line infections in children[J]. J Infect, 2015, 71(Suppl 1):59-75.
[40]
Choi SJ, Lee KJ, Choi JS, et al. Poor prognostic factors in patients with parenteral nutrition-dependent pediatric intestinal failure[J]. Pediatr Gastroenterol Hepatol Nutr, 2016, 19(1):44-53.
[41]
Kawano T, Kaji T, Onishi S, et al. Efficacy of ethanol locks to reduce the incidence of catheter-related bloodstream infections for home parenteral nutrition pediatric patients:comparison of therapeutic treatment with prophylactic treatment[J]. Pediatr Surg Int, 2016, 32(9):863-867.
[42]
Duesing LA, Fawley JA, Wagner AJ. Central venous access in the pediatric population with emphasis on complications and prevention strategies[J]. Nutr Clin Pract, 2016, 31(4):490-501.
[43]
Hulshof EC, Hanff LM, Olieman J, et al. Taurolidine in pediatric home parenteral nutrition patients[J]. Pediatr Infect Dis J, 2017, 36(2):233-235.
[44]
Mateu-de Antonio J, Florit-Sureda M. New strategy to reduce hypertriglyceridemia during parenteral nutrition while maintaining energy intake[J]. JPEN J Parenter Enteral Nutr, 2016, 40(5):705-712.
[45]
Wischmeyer PE, Heyland DK. The future of critical care nutrition therapy[J]. Crit Care Clin, 2010, 26(3):433-441.
[46]
Nguyen NQ, Fraser RJ, Chapman M, et al. Fasting and nutrient stimulated plasma peptide-yy levels are elevated in critical illness and associated with feed intolerance:an observational controlled study[J]. Crit Care, 2006, 10(6):R175.
[47]
Genton L, Dupertuis YM, Romand JA, et al. Higher calorie prescription improves nutrient delivery during the first 5 days of enteral nutrition[J]. Clin Nutr, 2004, 23(3):307-315.
[48]
Daniel Martin A, Smith BK, Gabrielli A. Mechanical ventilation, diaphragm weakness and weaning:a rehabilitation perspective[J]. Respir Physiol Neurobiol, 2013, 189(2):377-383.
[49]
Ridley EJ, Davies AR, Parke R. Supplemental parenteral nutrition in critically ill patients a study protocol for a phase Ⅱ randomised controlled trial[J]. Trials, 2015, 16:587.
